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Accepted manuscript

Effects of fat-emulsion-based early parenteral nutrition for patients after hemihepatectomy

Published online by Cambridge University Press:  24 March 2025

Leyi Liao ,
Yang Lei ,
Qinghua He ,
Hanbiao Liang ,
Jie Zhou ,
Kai Wang  and
Chuanjiang Li Open the ORCID record for Chuanjiang Li [Opens in a new window]
Leyi Liao
Affiliation:
Division of Hepatobiliopancreatic Surgery, Department of General Surgery, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, China.
Yang Lei
Affiliation:
Division of Hepatobiliopancreatic Surgery, Department of General Surgery, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, China.
Qinghua He
Affiliation:
Department of Hepatobiliary Surgery, Shenzhen Traditional Chinese Medicine Hospital, The Fourth Clinical Medical College of Guangzhou University of Chinese Medicine, Shenzhen, China
Hanbiao Liang
Affiliation:
Division of Hepatobiliopancreatic Surgery, Department of General Surgery, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, China.
Jie Zhou*
Affiliation:
Division of Hepatobiliopancreatic Surgery, Department of General Surgery, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, China.
Kai Wang*
Affiliation:
Division of Hepatobiliopancreatic Surgery, Department of General Surgery, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, China.
Chuanjiang Li*
Affiliation:
Division of Hepatobiliopancreatic Surgery, Department of General Surgery, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, China.
*
*Corresponding Author: Jie Zhou, MD, Division of Hepatobiliopancreatic Surgery, Department of General Surgery, Nanfang Hospital, Southern Medical University, 1838 North Guangzhou Avenue, Guangzhou 510515, Guangdong, China. E-mail: [email protected]. Tel: +86-020-61641701; Kai Wang, MD, Division of Hepatobiliopancreatic Surgery, Department of General Surgery, Nanfang Hospital, Southern Medical University, 1838 North Guangzhou Avenue, Guangzhou 510515, Guangdong, China, Email: [email protected]; Tel: +86-020-62787180; Chuanjiang Li, MD, Division of Hepatobiliopancreatic Surgery, Department of General Surgery, Nanfang Hospital, Southern Medical University, 1838 North Guangzhou Avenue, Guangzhou 510515, Guangdong, China, Email: [email protected]; Tel: +86-020-62787180
*Corresponding Author: Jie Zhou, MD, Division of Hepatobiliopancreatic Surgery, Department of General Surgery, Nanfang Hospital, Southern Medical University, 1838 North Guangzhou Avenue, Guangzhou 510515, Guangdong, China. E-mail: [email protected]. Tel: +86-020-61641701; Kai Wang, MD, Division of Hepatobiliopancreatic Surgery, Department of General Surgery, Nanfang Hospital, Southern Medical University, 1838 North Guangzhou Avenue, Guangzhou 510515, Guangdong, China, Email: [email protected]; Tel: +86-020-62787180; Chuanjiang Li, MD, Division of Hepatobiliopancreatic Surgery, Department of General Surgery, Nanfang Hospital, Southern Medical University, 1838 North Guangzhou Avenue, Guangzhou 510515, Guangdong, China, Email: [email protected]; Tel: +86-020-62787180
*Corresponding Author: Jie Zhou, MD, Division of Hepatobiliopancreatic Surgery, Department of General Surgery, Nanfang Hospital, Southern Medical University, 1838 North Guangzhou Avenue, Guangzhou 510515, Guangdong, China. E-mail: [email protected]. Tel: +86-020-61641701; Kai Wang, MD, Division of Hepatobiliopancreatic Surgery, Department of General Surgery, Nanfang Hospital, Southern Medical University, 1838 North Guangzhou Avenue, Guangzhou 510515, Guangdong, China, Email: [email protected]; Tel: +86-020-62787180; Chuanjiang Li, MD, Division of Hepatobiliopancreatic Surgery, Department of General Surgery, Nanfang Hospital, Southern Medical University, 1838 North Guangzhou Avenue, Guangzhou 510515, Guangdong, China, Email: [email protected]; Tel: +86-020-62787180
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Abstract

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This study investigates the effects of fat-emulsion-based early parenteral nutrition in patients following hemihepatectomy, addressing a critical gap in clinical knowledge regarding parenteral nutrition after hemihepatectomy. We retrospectively analyzed clinical data from 274 patients received non-fat-emulsion-based parenteral nutrition (non-fatty nutrition group) and 297 patients received fat-emulsion-based parenteral nutrition (fatty nutrition group) after hemihepatectomy. Fat-emulsion-based early parenteral nutrition significantly reduced levels of postoperative aspartate aminotransferase, total bilirubin, and direct bilirubin, while minor decreases in red blood cell and platelet counts were observed in the fatty nutrition group. Importantly, fat-emulsion-based early parenteral nutrition shortened lengths of postoperative hospital stay and fasting duration, but did not affect the incidence of short-term postoperative complications. Subgroup analyses revealed that the supplement of omega-3 fish oil emulsions was significantly associated with a reduced inflammatory response and risk of postoperative infections. These findings indicate that fat-emulsion-based early parenteral nutrition enhances short-term postoperative recovery in patients undergoing hemihepatectomy.

Keywords

HemihepatectomyIntravenous fat emulsionsParenteral nutritionOmega-3 fatty acidsPerioperative period
Type
Research Article
Information
British Journal of Nutrition , Accepted manuscript , pp. 1 - 23
Copyright
© The Author(s), 2025. Published by Cambridge University Press on behalf of The Nutrition Society

Footnotes

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These authors contributed equally to this study.