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The effect of wheat bran and pectin on paracetamol absorption in the rat

Published online by Cambridge University Press:  09 December 2008

R. C. Brown ,
J. Kelleher ,
B. E. Walker  and
M. S. Losowsky
R. C. Brown
Affiliation:
Department of Medicine, St James's Hospital, Leeds LS9 7TF
J. Kelleher
Affiliation:
Department of Medicine, St James's Hospital, Leeds LS9 7TF
B. E. Walker
Affiliation:
Department of Medicine, St James's Hospital, Leeds LS9 7TF
M. S. Losowsky
Affiliation:
Department of Medicine, St James's Hospital, Leeds LS9 7TF
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Abstract

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1. The absorption of an oral dose of paracetamol was measured in rats given either a basal fibre-free diet, or the basal diet with either pectin or bran added.

2. Urinary excretion of the oral dose was significantly greater during the first 8 h in the pectin-fed rats compared with those on basal diet, though cumulative excretion after 72 h was the same.

3. Free paracetamol levels in the plasma were significantly higher in the pectin-fed rats compared with those on basal diet at 30, 60, 90 and 120 min after the oral dose.

4. The plasma half-life of intravenously-injected paracetamol was shorter in the pectin-fed rats than in those on basal diet alone, but the antipyrine half-lives were not significantly different.

5. Pectin feeding had no effect on either the apparent volume of distribution of paracetamol and antipyrine, or on the rate of gastric emptying.

6. Perfusion of the whole length of the small bowel showed a significantly greater capacity for paracetamol absorption in the pectin-fed rats.

7. Bran had no effect on paracetamol absorption.

8. It was concluded that dietary fibre intake affects drug absorption and that the effect varies with the type of fibre. Unexpectedly pectin accelerates rather than retards absorption of paracetamol, though the mechanism of this effect is unknown.

Type
Papers of direct relevance to Clinical and Human Nutrition
Information
British Journal of Nutrition , Volume 41 , Issue 3 , May 1979 , pp. 455 - 464
Copyright
Copyright © The Nutrition Society 1979

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