Hostname: page-component-586b7cd67f-rdxmf Total loading time: 0 Render date: 2024-11-26T13:00:11.390Z Has data issue: false hasContentIssue false
  • English
  • Français

Effect of capsaicin on substrate oxidation and weight maintenance after modest body-weight loss in human subjects

Published online by Cambridge University Press:  09 March 2007

Manuela P. G. M. Lejeune ,
Eva M. R. Kovacs  and
Margriet S. Westerterp-Plantenga
Manuela P. G. M. Lejeune*
Affiliation:
Department of Human Biology, Maastricht University, P. O. Box 616, NL-6200 MD Maastricht, The Netherlands
Eva M. R. Kovacs
Affiliation:
Department of Human Biology, Maastricht University, P. O. Box 616, NL-6200 MD Maastricht, The Netherlands
Margriet S. Westerterp-Plantenga
Affiliation:
Department of Human Biology, Maastricht University, P. O. Box 616, NL-6200 MD Maastricht, The Netherlands
*
*Corresponding author: Ms Manuela P. G. M. Lejeune, fax +31 43 3670976, email [email protected]
Rights & Permissions [Opens in a new window]

Abstract

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.

The aim of the present study was to investigate whether capsaicin assists weight maintenance by limiting weight regain after weight loss of 5 to 10%. In this randomized double-blind placebo-controlled study, ninety-one moderately overweight subjects were randomly assigned to an intensive group that underwent all the measurements, and an extensive group that underwent the same measurements except the metabolism measurements. After a 4-week very-low-energy diet (VLED) intervention, a 3-month weight-maintenance period followed. During weight maintenance, subjects were divided into a capsaicin (135 mg capsaicin/d) and a placebo group. Body mass was measured before and after the VLED and after 1, 2 and 3 months of weight maintenance. The mean body-mass loss during the VLED was 6·6 (sd 2·0) kg (7·8 (sd 1·8)% initial body mass), and was not different between the subsequent treatment and placebo group. During weight maintenance, mean % regain during treatment was not significantly different compared with placebo (33·3 (sd 35·7) v. 19·2 (sd 41·8)%, P=0·09). RQ was significantly less increased during weight maintenance in the treatment group compared with placebo (0·04 (sd 0·06) v. 0·07 (sd 0·05), P < 0·05), indicating a relatively more sustained fat oxidation. Fat oxidation (g/h) after weight maintenance was higher in the capsaicin group compared with placebo (4·2 (sd 1·1) v. 3·5 (sd 0·9), P < 0·05). These results indicate that capsaicin treatment caused sustained fat oxidation during weight maintenance compared with placebo. However, capsaicin treatment has no limiting effect on 3-month weight regain after modest weight loss.

Keywords

AppetiteEnergy expenditureFat oxidation
Type
Research Article
Information
British Journal of Nutrition , Volume 90 , Issue 3 , September 2003 , pp. 651 - 659
Copyright
Copyright © The Nutrition Society 2003

References

Clark, MM, Marcus, BH, Pera, V & Niaura, R (1994) Changes in eating inventory scores following obesity treatment. Int J Eat Disord 15, 401–405.CrossRefGoogle ScholarPubMed
Ekelund, U, Yngve, A, Sjöström, M & Westerterp, KR (2000) Field evaluation of the computer science and application's inc. activity monitor during running and skating training in adolescent athletes. Int J Sports Med 21, 586–592.CrossRefGoogle ScholarPubMed
Goldstein, DJ (1992) Beneficial effects of modest weight loss. Int J Obes 16, 397–415.Google ScholarPubMed
Goris, AH & Westerterp, KR (1999) Underreporting of habitual food intake is explained by undereating in highly motivated lean women. J Nutr 129, 878–882.CrossRefGoogle ScholarPubMed
Goris, AH & Westerterp, KR (2000) Improved reporting of habitual food intake after confrontation with earlier results on food reporting. Br J Nutr 83, 363–369.CrossRefGoogle ScholarPubMed
Goris, AH, Westerterp-Plantenga, MS & Westerterp, KR (2000) Undereating and underrecording of habitual food intake in obese men: selective underreporting of fat intake. Am J Clin Nutr 71, 130–134.CrossRefGoogle ScholarPubMed
Goris, AHC, Meijer, EP, Kester, A & Westerterp, KR (2001) Use of a triaxial accelerometer to validate reported food intakes. Am J Clin Nutr 73, 549–553.CrossRefGoogle ScholarPubMed
Herman, CP & Polivy, J (1980) Restrained eating. In Obesity, pp. 208–224 [Stunkard, AJ, editor]. Philadelphia, PA: W. B. Saunders.Google Scholar
Hubert, HB, Feinleib, M, McNamara, PM & Castelli, WP (1983) Obesity as an independent risk factor for cardiovascular disease: a 26-year follow-up of participants in the Framingham Heart Study. Circulation 67, 968–977.CrossRefGoogle ScholarPubMed
Kawada, T, Hagihara, K & Iwai, K (1986) Effects of capsaicin on lipid metabolism in rats fed high fat diet. J Nutr 116, 1272–1278.CrossRefGoogle Scholar
Kawada, T, Sakabe, S, Watanabe, T, Yamamoto, M & Iwai, K (1988) Some pungent principles of spices cause the adrenal medulla to secrete catecholamine in anesthesized rats. Proc Soc Exp Biol Med 188, 229–233.CrossRefGoogle Scholar
Kramer, FM, Jeffery, RW, Forster, JL & Snell, MK (1989) Long-term follow-up of behavioral treatment for obesity: patterns of weight regain among men and women. Int J Obes 13, 123–136.Google ScholarPubMed
Kromhout, D (1983) Body weight, diet, and serum cholesterol in 871 middle-aged men during 10 years of follow-up (the Zutphen Study). Am J Clin Nutr 38, 591–598.CrossRefGoogle ScholarPubMed
Noppa, H (1980) Body weight change in relation to incidence of ischemic heart disease and change in risk factors for ischemic heart disease. Am J Epidemiol 111, 693–704.CrossRefGoogle ScholarPubMed
Pasman, WJ, Saris, WH & Westerterp-Plantenga, MS (1998) Predictors of weight maintenance. Obes Res 7, 43–50.CrossRefGoogle Scholar
Pasman, WJ, Saris, WHM, Muls, E, Vansant, G & Westerterp-Plantenga, MS (1999) The effect of exercise training on long-term weight maintenance in weight-reduced men. Metabolism 48, 15–21.CrossRefGoogle ScholarPubMed
Pasman, WJ, Westerterp-Plantenga, MS, Muls, E, Vansant, G, Van Ree, J & Saris, WHM (1997 a) The effectiveness of long-term fiber supplementation on weight maintenance in weight reduced women. Int J Obes 21, 548–555.CrossRefGoogle ScholarPubMed
Pasman, WJ, Westerterp-Plantenga, MS & Saris, WHM (1997 b) The effectiveness of long-term supplementation of carbohydrate, chromium, fiber and caffeine on weight maintenance. Int J Obes 21, 1143–1151.CrossRefGoogle ScholarPubMed
Pekkarinen, T, Takala, I & Mustajoki, P (1996) Two year maintenance of weight loss after a VLCD and behavioural therapy for obesity: correlation to the scores of questionnaires measuring eating behaviour. Int J Obes 20, 332–337.Google Scholar
Péronnet, F & Massicotte, D (1991) Table of nonprotein respiratory quotient: an update. Can J Sport Sci 16, 23–29.Google ScholarPubMed
Pullar, JD & Webster, AJF (1977) The energy cost of fat and protein deposition in the rat. Br J Nutr 37, 355–363.CrossRefGoogle ScholarPubMed
Ravussin, E & Bogardus, C (1989) Relationship of genetics, age, and physical fitness to daily energy expenditure and fuel utilization. Am J Clin Nutr 49, 968–975.CrossRefGoogle ScholarPubMed
Ravussin, E, Fontvieille, AM, Swinburn, BA & Bogardus, C (1993) Risk factors for the development of obesity. Ann N Y Acad Sci 683, 141–150.CrossRefGoogle ScholarPubMed
Schoeller, DA, Van Santen, E, Peterson, DW, Diez, W, Jaspan, J & Klein, PD (1980) Total body water measurement in humans with 18O and 2H labeled water. Am J Clin Nutr 33, 2686–2693.CrossRefGoogle ScholarPubMed
Schoffelen, PFM, Westerterp, KR, Saris, WHM & Ten, Hoor F (1997) A dual respiration chamber with automated calibration. J Appl Physiol 83, 2064–2072.CrossRefGoogle ScholarPubMed
Schutz, Y (1995) Abnormalities of fuel utilization as predisposing to the development of obesity in humans. Obes Res 3, 173S–178S.CrossRefGoogle Scholar
Seidell, JC (1995) Obesity in Europe. Obes Res 3, Suppl. 2, 249s–259s.CrossRefGoogle ScholarPubMed
Seidell, JC, Muller, DC, Sorkin, JD & Andres, R (1992) Fasting respiratory exchange ratio and resting metabolic rate as predictors of weight gain: the Baltimore Longitudinal Study on Aging. Int J Obes 16, 667–674.Google ScholarPubMed
Stunkard, AJ & Messick, S (1985) The three factor eating questionnaire to measure dietary restraint, disinhibition and hunger. J Psychol Res 29, 71–83.Google ScholarPubMed
Van Gaal, LF, Wauters, MA & De Leeuw, IH (1997) The beneficial effects of modest weight loss on cardiovascular risk factors. Int J Obes 21, Suppl. 1, S5–S9.Google ScholarPubMed
Van Marken Lichtenbelt, WD, Westerterp, KR & Wouters, L (1994) Deuterium dilution as a method for determining total body water: effect of test protocol and sampling time. Br J Nutr 72, 491–497.CrossRefGoogle ScholarPubMed
Wadden, TA, Stunkard, AJ & Liebschutz, J (1988) Three-year follow-up of the treatment of obesity by very low calorie diet, behavior therapy, and their combination. J Consult Clin Psychol 56, 925–928.CrossRefGoogle ScholarPubMed
Weir, JBDV (1949) New methods for calculating metabolic rate with special references to protein metabolism. J Physiol 109, 1–9.CrossRefGoogle ScholarPubMed
Westerterp-Plantenga, MS, Kempen, KPG & Saris, WHM (1998) Determinants of weight maintenance in women after diet-induced weight reduction. Int J Obes 22, 1–6.CrossRefGoogle ScholarPubMed
Westerterp-Plantenga, MS, Rolland, V, Wilson, SAJ & Westerterp, KR (1999) Satiety related to 24 h diet-induced thermogenesis during high protein/carbohydrate vs. high fat diets measured in a respiration chamber. Eur J Clin Nutr 53, 495–502.CrossRefGoogle Scholar
Wing, RR, Jeffery, RW, Burton, LR, Thorson, C, Kuller, LH & Folsom, AR (1992) Change in waist-hip ratio with weight loss and its association with change in cardiovascular risk factors. Am J Clin Nutr 55, 1086–1092.CrossRefGoogle ScholarPubMed
Yoshioka, M, Doucet, E, Drapeau, V, Dionne, I & Tremblay, A (2001) Combined effects of red pepper and caffeine consumption on 24 h energy balance in subjects given free access to foods. Br J Nutr 85, 203–211.CrossRefGoogle ScholarPubMed
Yoshioka, M, Lim, K, Kikuzato, S, et al. (1995) Effects of red-pepper diet on the energy metabolism in men. J Nutr Sci Vitaminol 41, 647–656.CrossRefGoogle ScholarPubMed
Yoshioka, M, St-Pierre, S, Drapeau, V, et al. (1999) Effects of red pepper on appetite and energy intake. Br J Nutr 82, 115–123.CrossRefGoogle ScholarPubMed
Yoshioka, M, St-Pierre, S, Suzuki, M & Tremblay, A (1998) Effects of red pepper added to high-fat and high-carbohydrate meals on energy metabolism and substrate utilization in Japanese women. Br J Nutr 80, 503–510.CrossRefGoogle ScholarPubMed
Zurlo, F, Lillioja, S, Esposito-Del, Puente A, et al. (1990) Low ratio of fat to carbohydrate oxidation as predictor of weight gain: study of 24-h RQ. Am J Physiol 259, E650–E657.Google ScholarPubMed