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Coenzyme Q10 mitigates high-fat-diet-induced hepatic steatosis in spotted bass (Lateolabrax maculatus) through modulating mitochondrial function

Published online by Cambridge University Press:  31 March 2025

Xiaojiang Mao Open the ORCID record for Xiaojiang Mao [Opens in a new window] ,
Xueshan Li ,
Ling Wang ,
Kai Song ,
Chunxiao Zhang ,
Bei Huang ,
Kangle Lu Open the ORCID record for Kangle Lu [Opens in a new window]  and
Samad Rahimnejad
Xiaojiang Mao
Affiliation:
State Key Laboratory of Mariculture Breeding; Fisheries College, Jimei University, Xiamen 361021, People’s Republic of China
Xueshan Li
Affiliation:
State Key Laboratory of Mariculture Breeding; Fisheries College, Jimei University, Xiamen 361021, People’s Republic of China
Ling Wang
Affiliation:
State Key Laboratory of Mariculture Breeding; Fisheries College, Jimei University, Xiamen 361021, People’s Republic of China
Kai Song
Affiliation:
State Key Laboratory of Mariculture Breeding; Fisheries College, Jimei University, Xiamen 361021, People’s Republic of China
Chunxiao Zhang
Affiliation:
State Key Laboratory of Mariculture Breeding; Fisheries College, Jimei University, Xiamen 361021, People’s Republic of China
Bei Huang
Affiliation:
State Key Laboratory of Mariculture Breeding; Fisheries College, Jimei University, Xiamen 361021, People’s Republic of China
Kangle Lu*
Affiliation:
State Key Laboratory of Mariculture Breeding; Fisheries College, Jimei University, Xiamen 361021, People’s Republic of China
Samad Rahimnejad
Affiliation:
Faculty of Fisheries and Protection of Waters, University of South Bohemia in České Budějovice, South Bohemian Research Centre of Aquaculture and Biodiversity of Hydrocenoses, Vodňany 389 25, Czech Republic
*
Corresponding author: Kangle Lu; Email: [email protected]
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Abstract

This study elucidated the impacts of coenzyme Q10 (COQ10) supplementation in a high-fat diet (HFD) on growth, lipid metabolism and mitochondrial function in spotted seabass (Lateolabrax maculatus). Totally five diets were formulated: a diet with normal fat content (11 % lipid, NFD), a HFD (17 % lipid) and three additional diets by supplementing 5, 20 or 80 mg/kg of COQ10 to the HFD. After an 8-week culture period, samples were collected and analysed. The results demonstrated that COQ10 inclusion prevented the HFD-induced deterioration of growth performance and feed utilisation. COQ10 alleviated the deposition of saturated fatty acids following HFD intake and promoted the assimilation of n-3 and n-6 PUFA. Moreover, COQ10 administration inhibited the surge in serum transaminase activity and reduced hepatic lipid content following HFD ingestion, which was consistent with the results of oil red O staining. In addition, HFD feeding led to reduced hepatic citrate synthase and succinate dehydrogenase activities and decreased ATP content. Notably, COQ10 administration improved these indices and up-regulated the expression of mitochondrial biogenesis-related genes (pgc-1α, pgc-1β, nrf-1, tfam) and autophagy-related genes (pink1, mul1, atg5). In summary, supplementing 20–80 mg/kg of COQ10 in the HFD promoted growth performance, alleviated hepatic fat accumulation and enhanced liver mitochondrial function in spotted seabass.

Keywords

Spotted seabassHigh-fat feedCoenzyme Q10Liver healthMitochondrial function
Type
Research Article
Information
British Journal of Nutrition , First View , pp. 1 - 15
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Copyright
© The Author(s), 2025. Published by Cambridge University Press on behalf of The Nutrition Society

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