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Associations between inflammation-related dietary patterns and obesity: a cohort study among Tibetan adults

Published online by Cambridge University Press:  24 January 2025

Xiaomin Sun Open the ORCID record for Xiaomin Sun [Opens in a new window] ,
Wenxiu Jian ,
Xiao Tang ,
Rui Li ,
Bin Zhang ,
Yingxin Chen ,
Haijing Wang ,
Lei Zhao ,
Yangrui Zhang  and
Kumpei Tanisawa
...Show all authors
Xiaomin Sun
Affiliation:
International Obesity and Metabolic Disease Research Center, Global Health Institute, School of Public Health, Xi’an Jiaotong University, Xi’an 710061, People’s Republic of China
Wenxiu Jian
Affiliation:
Department of Public Health, Qinghai University Medical College, Xining 810016, People’s Republic of China
Xiao Tang
Affiliation:
Department of Public Health, Qinghai University Medical College, Xining 810016, People’s Republic of China
Rui Li
Affiliation:
International Obesity and Metabolic Disease Research Center, Global Health Institute, School of Public Health, Xi’an Jiaotong University, Xi’an 710061, People’s Republic of China
Bin Zhang
Affiliation:
School of Mathematics and Statistics, Qinghai Minzu University, Xining 810007, People’s Republic of China
Yingxin Chen
Affiliation:
International Obesity and Metabolic Disease Research Center, Global Health Institute, School of Public Health, Xi’an Jiaotong University, Xi’an 710061, People’s Republic of China
Haijing Wang
Affiliation:
Department of Public Health, Qinghai University Medical College, Xining 810016, People’s Republic of China
Lei Zhao
Affiliation:
Department of Public Health, Qinghai University Medical College, Xining 810016, People’s Republic of China
Yangrui Zhang
Affiliation:
Department of Public Health, Qinghai University Medical College, Xining 810016, People’s Republic of China
Kumpei Tanisawa
Affiliation:
Faculty of Sport Sciences, Waseda University, Saitama 359-1192, Japan
Zumin Shi
Affiliation:
Department of Nutrition Sciences, College of Health Sciences, QU Health, Qatar University, Doha 2713, Qatar
Youfa Wang*
Affiliation:
International Obesity and Metabolic Disease Research Center, Global Health Institute, School of Public Health, Xi’an Jiaotong University, Xi’an 710061, People’s Republic of China
Wen Peng*
Affiliation:
Department of Public Health, Qinghai University Medical College, Xining 810016, People’s Republic of China Qinghai Provincial Key Laboratory of Prevention and Control of Glucolipid Metabolic Diseases with Traditional Chinese Medicine, Xining 810016, People’s Republic of China
*
Corresponding authors: Youfa Wang; Email: [email protected]; Wen Peng; Email: [email protected]
Corresponding authors: Youfa Wang; Email: [email protected]; Wen Peng; Email: [email protected]
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Abstract

Substantial changes resulting from the interaction of environmental and dietary factors contribute to an increased risk of obesity, while their specific associations with obesity remain unclear. We identified inflammation-related dietary patterns (DP) and explored their associations with obesity among urbanised Tibetan adults under significant environmental and dietary changes. Totally, 1826 subjects from the suburbs of Golmud City were enrolled in an open cohort study, of which 514 were followed up. Height, weight and waist circumference were used to define overweight and obesity. DP were derived using reduced rank regression with forty-one food groups as predictors and high-sensitivity C-reactive protein and prognostic nutritional index as inflammatory response variables. Altitude was classified as high or ultra-high. Two DP were extracted. DP-1 was characterised by having high consumptions of sugar-sweetened beverages, savoury snacks, and poultry and a low intake of tsamba. DP-2 had high intakes of poultry, pork, animal offal, and fruits and a low intake of butter tea. Participants in the highest tertiles (T3) of DP had increased risks of overweight and obesity (DP-1: OR = 1·37, 95 % CI 1·07, 1·77; DP-2: OR = 1·48, 95 % CI 1·18, 1·85) than those in the lowest tertiles (T1). Participants in T3 of DP-2 had an increased risk of central obesity (OR = 2·25, 95 % CI 1·49, 3·39) than those in T1. The positive association of DP-1 with overweight and obesity was only significant at high altitudes, while no similar effect was observed for DP-2. Inflammation-related DP were associated with increased risks of overweight and/or obesity.

Keywords

Inflammatory-related dietary patternsReduced rank regressionOverweightObesityTibetan Plateau
Type
Research Article
Information
British Journal of Nutrition , First View , pp. 1 - 10
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Copyright
© The Author(s), 2025. Published by Cambridge University Press on behalf of the Nutrition Society

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Footnotes

‡

These authors contributed equally to this work

†

Senior author contributed equally as corresponding authors

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