Hostname: page-component-78c5997874-g7gxr Total loading time: 0 Render date: 2024-11-19T07:18:42.820Z Has data issue: false hasContentIssue false
  • English
  • Français

Quantifying resilience: Theoretical or pragmatic for translational research?

Published online by Cambridge University Press:  02 September 2015

Gleb P. Shumyatsky ,
Tanja Jovanovic  and
Talma Handler
Gleb P. Shumyatsky
Affiliation:
Department of Genetics, Rutgers The State University of New Jersey,Piscataway, NJ [email protected]
Tanja Jovanovic
Affiliation:
Department of Psychiatry & Behavioral Sciences, Emory University School of Medicine, Atlanta, GA [email protected]
Talma Handler
Affiliation:
Tel Aviv Functional Brain Center, Tel Aviv University, Tel Aviv 69978, Israel. [email protected]
Get access Rights & Permissions [Opens in a new window]

Abstract

Quantifying resilience allows for several testable hypotheses, such as that resilience is equal to the number of mental health problems given a known quantity of stressor load. The proposed model lends itself well to prospective studies with data collection pre- and post-adversity; however, prestressor assessments are not always available. Challenges remain for adapting quantifying resilience to animal research, even if the idea of its translation value is significant.

Type
Open Peer Commentary
Information
Behavioral and Brain Sciences , Volume 38 , 2015 , e119
Copyright
Copyright © Cambridge University Press 2015 

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Admon, R., Milad, M. R. & Hendler, T. (2013) A causal model of post-traumatic stress disorder: Disentangling predisposed from acquired neural abnormalities. Trends in Cognitive Sciences 17(7):337–47. doi: 10.1016/j.tics.2013.05.005.CrossRefGoogle ScholarPubMed
Binder, E. B., Bradley, R. G., Liu, W., Epstein, M. P., Deveau, T. C., Mercer, K. B., Tang, Y., Gillespie, C. F., Heim, C. M., Nemeroff, C. B., Schwartz, A. C., Cubells, J. F. & Ressler, K. J. (2008) Association of FKBP5 polymorphisms and childhood abuse with risk of posttraumatic stress disorder symptoms in adults. Journal of the American Medical Association 299(11):1291–305. doi: 10.1001/jama.299.11.1291.CrossRefGoogle ScholarPubMed
Bremner, J. D., Southwick, S. M., Darnell, A. & Charney, D. S. (1996) Chronic PTSD in Vietnam combat veterans: Course of illness and substance abuse. American Journal of Psychiatry 153:369–75.Google ScholarPubMed
Cuthbert, B. N. (2014a) The RDoC framework: Facilitating transition from ICD/DSM to dimensional approaches that integrate neuroscience and psychopathology. World Psychiatry 13(1):28–35. doi: 10.1002/wps.20087.CrossRefGoogle ScholarPubMed
Elhai, J. D., Gray, M. J., Kashdan, T. B. & Franklin, C. L. (2005) Which instruments are most commonly used to assess traumatic event exposure and posttraumatic effects? A survey of traumatic stress professionals. Journal of Traumatic Stress 18(5):541–45. doi: 10.1002/jts.20062.CrossRefGoogle ScholarPubMed
Etkin, A., Egner, T., Peraza, D. M., Kandel, E. R. & Hirsch, J. (2006) Resolving emotional conflict: A role for the rostral anterior cingulate cortex in modulating activity in the amygdala. Neuron 51(6):871–82.CrossRefGoogle ScholarPubMed
Etkin, A. & Wager, T. (2007) Functional neuroimaging of anxiety: A meta-analysis of emotional processing in PTSD, social anxiety disorder, and specific phobia. American Journal of Psychiatry 164(10):1476–88. doi: 10.1176/appi.ajp.2007.07030504.CrossRefGoogle ScholarPubMed
Feder, A., Ahmad, S., Lee, E. J., Morgan, J. E., Singh, R., Smith, B. W., Southwick, S. M. & Charney, D. S. (2013) Coping and PTSD symptoms in Pakistani earthquake survivors: Purpose in life, religious coping and social support. Journal of Affective Disorders 147(1–3):156–63. doi: 10.1016/j.jad.2012.10.027.CrossRefGoogle ScholarPubMed
Glover, E. M., Jovanovic, T., Mercer, K. B., Kerley, K., Bradley, B., Ressler, K. J. & Norrholm, S. D. (2012) Estrogen levels are associated with extinction deficits in women with posttraumatic stress disorder. Biological Psychiatry 72(1):19–24. doi: 10.1016/j.biopsych.2012.02.031.CrossRefGoogle ScholarPubMed
Insel, T., Cuthbert, B., Garvey, M., Heinssen, R., Pine, D. S., Quinn, K., Sanislow, C. & Wang, P. (2010) Research domain criteria (RDoC): Toward a new classification framework for research on mental disorders. American Journal of Psychiatry 167(7):748–51.CrossRefGoogle Scholar
Milad, M. R., Pitman, R. K., Ellis, C. B., Gold, A. L., Shin, L. M., Lasko, N.. B., Zeidan, M. A., Handwerger, K., Orr, S. P. & Rauch, S. L. (2009) Neurobiological basis of failure to recall extinction memory in posttraumatic stress disorder. Biological Psychiatry 66(12):1075–82.CrossRefGoogle ScholarPubMed
Morgan, C. A., III., Wang, S., Southwick, S. M., Rasmusson, A., Hazlett, G., Hauger, R. L. & Charney, D. S. (2000) Plasma neuropeptide-Y concentrations in humans exposed to military survival training. Biological Psychiatry 47(10):902–909. doi: 10.1016/S0006-3223(99)00239-5.CrossRefGoogle ScholarPubMed
Norrholm, S. D., Jovanovic, T., Smith, A., Binder, E. B., Klengel, T., Conneely, K., Mercer, K. B., Davis, J. S., Kerley, K., Winkler, J., Gillespie, C. F., Bradley, B. & Ressler, K. J. (2013) Differential genetic and epigenetic regulation of catechol-O-methyl-transferase is associated with impaired fear inhibition in posttraumatic stress disorder. Frontiers in Behavioral Neuroscience 7:30. doi: 10.3389/fnbeh.2013.00030.CrossRefGoogle Scholar
Rauch, S. L., Whalen, P. J., Shin, L. M., McInerney, S. C., Macklin, M. L., Lasko, N. B., Orr, S. P. & Pitman, R. K. (2000) Exaggerated amygdala response to masked facial stimuli in posttraumatic stress disorder: A functional MRI study. Biological Psychiatry 47(9):769–76.CrossRefGoogle ScholarPubMed
Reul, J. M. (2014) Making memories of stressful events: A journey along epigenetic, gene transcription, and signaling pathways. Frontiers in Psychiatry 5:1–11.CrossRefGoogle ScholarPubMed