Osmoregulation and salinity tolerance were studied in zoeae 1 and instar IX juveniles of Chionoecetes opilio. In zoeae 1, the lower and upper lethal salinities for 50% of the animals (LS 50) at 14 °C were about 10 and 42‰ at 24 h, 18 and 41‰ at 48 h, 25 and 38‰ at 96 h. In juveniles, the approximate 48 h LS 50 s at 6 °C were 13.5 and 46‰. Both developmental stages are able to withstand relatively ample but brief variations of salinity. Their short-term euryhalinity is discussed in relation to the salinity of their habitat. Zoeae were hyper-osmoconformers. Juveniles were osmoconformers and isoionic to the external medium except for Mg++ which was hypo-regulated. Isosmotic and isoionic regulation in post-metamorphic stages are presumably an attribute of the family Majidae. The pattern of osmoregulation in zoeae 1 and juveniles relate C. opilio to the first of three groups of species previously characterized by their pattern of ontogeny of osmoregulation.