The 1928 epidemic came a decade after the 1918–19 influenza pandemic. Using the rich epidemiological, biological, and historical evidence available from the 1918–19 pandemic, this chapter examines the relationship between these two episodes. What happened along the Mackenzie River in 1928 offers unique insight into the global reverberations of the appearance of a novel influenza virus ten years previously. This chapter also explores the effects of colonial power relations on the course of the epidemic and the ways in which this epidemic reinforced particular interpretations of ‘race’ and ‘racial’ difference in northern North America.