Chapter 14 returns to Britain in 1814–15, with Jenner hoping that peace would bring new opportunities to advance the vaccination cause. The end of the Napoleonic Wars and the reopening of lines of communication, bringing further reports of vaccination around the world, provides a useful vantage-point to identify key developments in the global story. Although the early history of vaccination is one of the diffusion of know-how and biomatter along the lines of Europe trade and empire, the networks rapidly become more complex and multilateral, with the new prophylaxis constructed on a global stage, not least the management of the practice, its integration in systems of public health and in legislative and other forms of coercion. Above all, it is possible to see vaccination as a quiet revolution, an emancipatory force, the pointy end of increasing state power and a foundation for further breakthroughs in the struggle against disease.