Theodosius Dobzhansky’s essay, “Nothing in Biology Makes Sense Except in the Light of Evolution,” reflects on how evolution gives a powerful perspective to biological phenomena, able to integrate disparate pieces of information into coherent narratives. Biology can be messy, with many organisms, cell types, parts, and data. The recent revolution in genomic technology has generated a deluge of data that, correctly interpreted, can illuminate the relationship between and the ancestry of different organisms, the mechanisms that give rise to variability, and how this variability enables organisms to adapt to new environments.