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7 - Neurocognitive Basis of Compulsivity

from Section 1 - Theoretical Foundations of Obsessive-Compulsive and Related Disorders

Published online by Cambridge University Press:  14 December 2018

Leonardo F. Fontenelle
Affiliation:
Federal University of Rio de Janeiro
Murat Yücel
Affiliation:
Monash University, Victoria
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Publisher: Cambridge University Press
Print publication year: 2019

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References

Denys, D. Obsessionality and compulsivity: a phenomenology of obsessive-compulsive disorder. Philos Ethics Humanit Med. 2011;6(3):17.Google Scholar
Robbins, TW, Gillan, CM, Smith, DG, et al. Neurocognitive endophenotypes of impulsivity and compulsivity: towards dimensional psychiatry. Trends Cogn Sci. 2012;16(1):8191.Google Scholar
Holden, C, “Behavioral” addictions: do they exist? Science. 2001;294:980982.Google Scholar
Denys, D, van der Wee, N, Janssen, J, et al. Low level of dopaminergic D2 receptor binding in obsessive-compulsive disorder. Biol Psychiatry. 2002;55:10411045.Google Scholar
Grant, JE, Brewer, JA, Potenza, MN. The neurobiology of substance and behavioral addictions. CNS Spectr. 2006;12:924930.Google Scholar
American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders (5th ed.). Washington, DC: APA; 2013.Google Scholar
Figee, M, Vink, M, de Geus, F, et al. Dysfunctional reward circuitry in obsessive-compulsive disorder. Biol Psychiatr. 2011;69(9):867874.Google Scholar
Figee, M, Luigjes, J, Smolders, R, et al. Deep brain stimulation restores frontostriatal network activity in obsessive-compulsive disorder. Nat Neurosci. 2014;17(9):1286.Google Scholar
Wrase, J, Schlagenhauf, F, Kienast, T, et al. Dysfunction of reward processing correlates with alcohol craving in detoxified alcoholics. Neuroimage. 2007;35(2):787794.Google Scholar
Buhler, M, Vollstadt-Klein, S, Kobiella, A, et al. Nicotine dependence is characterized by disordered reward processing in a network driving motivation. Biol Psychiatry. 2009;67:745752.Google Scholar
Van Hell, HH, Vink, M, Ossewaarde, L, et al. Chronic effects of cannabis use on the human reward system: an fMRI study. Eur Neuropsychopharmacol. 2010;20(3):153163.Google Scholar
Reuter, J, Raedler, T, Rose, M, et al. Pathological gambling is linked to reduced activation of the mesolimbic reward system. Nat Neurosci. 2005;8:147148.Google Scholar
De Greck, M, Enzi, B, Prösch, U, et al. Decreased neuronal activity in reward circuitry of pathological gamblers during processing of personal relevant stimuli. Hum Brain Mapp. 2010;31:18021812.Google Scholar
Luijten, M, Schellekens, AF, Kühn, S, et al. Disruption of reward processing in addiction: an image-based meta-analysis of functional magnetic resonance imaging studies. JAMA Psychiatry. 2017;74(4):387398.CrossRefGoogle ScholarPubMed
Rotge, J, Guehl, D, Dilharreguy, B, et al. Provocation of obsessive–compulsive symptoms: a quantitative voxel-based meta-analysis of functional neuroimaging studies. J Psychiatry Neurosci. 2008;33:405412.Google ScholarPubMed
Diekhof, EK, Falkai, P, Gruber, O. Functional neuroimaging of reward processing and decision-making: a review of aberrant motivational and affective processing in addiction and mood disorders. Brain Res Rev. 2008;59:164184.CrossRefGoogle ScholarPubMed
Zhu, Y, Hu, X, Wang, J, Chen, J, et al. Processing of food, body and emotional stimuli in anorexia nervosa: a systematic review and meta-analysis of functional magnetic resonance imaging studies. Eur Eat Disord Rev. 2012;20(6):439450.Google Scholar
Gearhardt, AN, Yokum, S, Orr, PT, et al. Neural correlates of food addiction. Arch Gen Psychiatry. 2011;68(8):808816.CrossRefGoogle ScholarPubMed
García-García, I, Horstmann, A, Jurado, MA, et al. Reward processing in obesity, substance addiction and non-substance addiction. Obes Rev. 2014;15(11):853869.Google Scholar
Wierenga, CE, Bischoff-Grethe, A, Melrose, AJ, et al. Hunger does not motivate reward in women remitted from anorexia nervosa. Biol Psychiatry. 2015;77(7):642652.CrossRefGoogle Scholar
Filbey, FM, Myers, US, Dewitt, S. Reward circuit function in high BMI individuals with compulsive overeating: similarities with addiction. Neuroimage. 2012;63:18001806.Google Scholar
Balodis, IM, Kober, H, Worhunsky, PD, et al. Monetary reward processing in obese individuals with and without binge eating disorder. Biol Psychiatry. 2013;73:877886.Google Scholar
Frank, GK, Reynolds, JR, Shott, ME, et al. Anorexia nervosa and obesity are associated with opposite brain reward response. Neuropsychopharmacology. 2012;37(9):20312046.CrossRefGoogle ScholarPubMed
Pinto, A, Steinglass, JE, Greene, AL, et al. Capacity to delay reward differentiates obsessive-compulsive disorder and obsessive-compulsive personality disorder. Biol Psychiatry. 2014;75(8):653659.CrossRefGoogle ScholarPubMed
Steinglass, JE, Lempert, KM, Choo, TH, et al. Temporal discounting across three psychiatric disorders: anorexia nervosa, obsessive compulsive disorder, and social anxiety disorder. Depress Anxiety. 2017;34(5):463470.Google Scholar
Kekic, M, Bartholdy, S, Cheng, J, et al. Increased temporal discounting in bulimia nervosa. Int J Eat Disord. 2016;49(12):10771081.CrossRefGoogle ScholarPubMed
Amlung, M, Vedelago, L, Acker, J, et al. Steep delay discounting and addictive behavior: a meta-analysis of continuous associations. Addiction. 2017;112(1):5162.CrossRefGoogle ScholarPubMed
Kaufmann, C, Beucke, JC, Preuße, , et al. Medial prefrontal brain activation to anticipated reward and loss in obsessive–compulsive disorder. Neuroimage Clin. 2013;2:212220.Google Scholar
Jung, WH, Kang, D-H, Han, JY, et al. Aberrant ventral striatal responses during incentive processing in unmedicated patients with obsessive–compulsive disorder. Acta Psychiatr Scand. 2011;123(5):376386.Google Scholar
Choi, JS, Shin, YC, Jung, WH, et al. Altered brain activity during reward anticipation in pathological gambling and obsessive–compulsive disorder. PloS One. 2012;7(9):e45938.Google Scholar
van Holst, RJ, Clark, L, Veltman, DJ, et al. Enhanced striatal responses during expectancy coding in alcohol dependence. Drug Alcohol Depend. 2014;142:204208.Google Scholar
Naqvi, NH, Rudrauf, D, Damasio, H, Bechara, A. Damage to the insula disrupts addiction to cigarette smoking. Science. 2007;315(5811):531534.Google Scholar
Wagner, A, Aizenstein, H, Venkatraman, VK, et al. Altered reward processing in women recovered from anorexia nervosa. Am J Psychiatry. 2007;164(12):18421849.Google Scholar
DeGuzman, M, Shott, ME, Yang, TT, et al. Association of elevated reward prediction error response with weight gain in adolescent anorexia nervosa. Am J Psychiatry. 2017;174(6):557565.Google Scholar
Frank, GK, Collier, S, Shott, ME, et al. Prediction error and somatosensory insula activation in women recovered from anorexia nervosa. J Psychiatry Neurosci. 2016;41(5):304311.Google Scholar
Koob, GF. The dark side of emotion: the addiction perspective. Eur J Pharmacol. 2015;753:7387.Google Scholar
Kennett, J, Matthews, S, Snoek, A. Pleasure and addiction. Front Psychiatry. 2013;4:117.CrossRefGoogle ScholarPubMed
Root, DH, Mejias-Aponte, CA, Qi, J, et al. Role of glutamatergic projections from ventral tegmental area to lateral habenula in aversive conditioning. J Neurosci. 2014;34(42):1390613910.Google Scholar
Vollstädt-Klein, S, Wichert, S, Rabinstein, J, et al. Initial, habitual and compulsive alcohol use is characterized by a shift of cue processing from ventral to dorsal striatum. Addiction. 2010;105(10):17411749.Google Scholar
Peters, J, Kalivas, PW, Quirk, GJ. Extinction circuits for fear and addiction overlap in prefrontal cortex. Learn Mem. 2009;16(5):279288.Google Scholar
Crunelle, CL, Kaag, AM, van den Munkhof, HE, et al. Dysfunctional amygdala activation and connectivity with the prefrontal cortex in current cocaine users. Hum Brain Mapp. 2015;36(10):42224230.Google Scholar
Goudriaan, AE, de Ruiter, MB, van den Brink, W, et al. Brain activation patterns associated with cue reactivity and craving in abstinent problem gamblers, heavy smokers and healthy controls: an fMRI study. Addict Biol. 2010;15(4):491503.Google Scholar
Rachman, S, de Silva, P, Roper, G. The spontaneous decay of compulsive urges. Behav Res Ther. 1976;14:445453.Google Scholar
Welkenhuysen, M, Gligorijevic, I, Ameye, L, et al. Neuronal activity in the bed nucleus of the stria terminalis in a rat model for obsessive–compulsive disorder. Behav Brain Res. 2013;240:5259.Google Scholar
Kashyap, H, Fontenelle, LF, Miguel, EC, et al. “Impulsive compulsivity” in obsessive–compulsive disorder: a phenotypic marker of patients with poor clinical outcome. J Psychiatr Res. 2012;46:11461152.Google Scholar
Whiteside, SP, Port, JD, Abramowitz, JS. A meta-analysis of functional neuroimaging in obsessive–compulsive disorder. Psychiatry Res. 2004;132(1):6979.Google Scholar
Radua, J, van den Heuvel, OA, Surguladze, S, Mataix-Cols, D. Meta-analytical comparison of voxel-based morphometry studies in obsessive–compulsive disorder vs other anxiety disorders. Arch Gen Psychiatry. 2010;67(7):701711.Google Scholar
Schulte, EM, Grilo, CM, Gearhardt, AN. Shared and unique mechanisms underlying binge eating disorder and addictive disorders. Clin Psychol Rev. 2016;44:125139.CrossRefGoogle ScholarPubMed
Chamberlain, SR, Fineberg, NA, Blackwell, AD, et al. Motor inhibition and cognitive flexibility in obsessive–compulsive disorder and trichotillomania. Am J Psychiatry. 2006;163:12821284.Google Scholar
Izquierdo, A, Jentsch, JD. Reversal learning as a measure of impulsive and compulsive behavior in addictions. Psychopharmacology (Berl). 2012;219(2):607620.Google Scholar
Goudriaan, AE, Oosterlaan, J, de Beurs, E. et al. Neurocognitive functions in pathological gambling: a comparison with alcohol dependence, Tourette syndrome and normal controls. Addiction. 2006;101:534547.Google Scholar
Vanes, LD, van Holst, RJ, Jansen, JM, et al. Contingency learning in alcohol dependence and pathological gambling: learning and unlearning reward contingencies. Alcohol Clin Exp Res. 2014;38(6):16021610.Google Scholar
Bechara, A, Damasio, H, Damasio, AR. Emotion, decision-making and the orbitofrontal cortex. Cereb Cortex. 2000;10:295307.Google Scholar
Remijnse, PL, Nielen, MM, van Balkom, AJ, et al. Reduced orbitofrontal-striatal activity on a reversal learning task in obsessive–compulsive disorder. Arch Gen Psychiatry. 2006;63(11):12251236.CrossRefGoogle ScholarPubMed
Chamberlain, SR, Menzies, L, Hampshire, A, et al. Orbitofrontal dysfunction in patients with obsessive–compulsive disorder and their unaffected relatives. Science. 2008;321:421422.Google Scholar
Franklin, TR, Acton, PD, Maldjian, JA, et al. Decreased gray matter concentration in the insular, orbitofrontal, cingulate, and temporal cortices of cocaine patients. Biol Psychiatry. 2002;51(2):134142.Google Scholar
Meunier, D, Ersche, KD, Craig, KJ, et al. Brain functional connectivity in stimulant drug dependence and obsessive–compulsive disorder. NeuroImage. 2012;59(2):14611468.Google Scholar
de Ruiter, MB, Veltman, DJ, Goudriaan, AE, et al. Response perseveration and ventral prefrontal sensitivity to reward and punishment in male problem gamblers and smokers. Neuropsychopharmacology. 2009;34:10271038.Google Scholar
Banca, P, Harrison, NA, Voon, V. Compulsivity across the pathological misuse of drug and non-drug rewards. Front Behav Neurosci. 2016;10:154.Google Scholar
Hildebrandt, T, Grotzinger, A, Reddan, M, et al. Testing the disgust conditioning theory of food-avoidance in adolescents with recent onset anorexia nervosa. Behav Res Ther. 2015;71:131138.Google Scholar
Hampshire, A, Owen, AM. Fractionating attentional control using event-related fMRI. Cereb Cortex. 2006;16:16791689.Google Scholar
Stalnaker, TA, Takahashi, Y, Roesch, MR, et al. Neural substrates of cognitive inflexibility after chronic cocaine exposure. Neuropharmacology. 2009;56(Suppl 1):S63S72.Google Scholar
Watkins, LH, Sahakian, BJ, Robertson, MM, et al. Executive function in Tourette’s syndrome and obsessive–compulsive disorder. Psychol Med. 2005;35:571582.CrossRefGoogle ScholarPubMed
Britton, JC, Rauch, SL, Rosso, IM, et al. Cognitive inflexibility and frontal-cortical activation in pediatric obsessive–compulsive disorder. J Am Acad Child Adolesc Psychiatry. 2010;49:944953.Google Scholar
Odlaug, BL, Chamberlain, SR, Kim, SW, et al. A neurocognitive comparison of cognitive flexibility and response inhibition in gamblers with varying degrees of clinical severity. Psychol Med. 2011;41:21112119.Google Scholar
Chamberlain, SR, Stochl, J, Redden, SA, et al. Latent class analysis of gambling subtypes and impulsive/compulsive associations: time to rethink diagnostic boundaries for gambling disorder? Addict Behav. 2017;72:7985.Google Scholar
Derbyshire, KL, Chamberlain, SR, Odlaug, BL, et al. Neurocognitive functioning in compulsive buying disorder. Ann Clin Psychiatry. 2014;26:5763.Google Scholar
Ornstein, TJ, Iddon, JL, Baldacchino, AM, et al. Profiles of cognitive dysfunction in chronic amphetamine and heroin abusers. Neuropsychopharmacology. 2000;23:113126.Google Scholar
Woicik, PA, Urban, C, Alia-Klein, N, et al. A pattern of perseveration in cocaine addiction may reveal neurocognitive processes implicit in the Wisconsin card sorting test. Neuropsychologia. 2011;49(7):16601669.CrossRefGoogle ScholarPubMed
Banca, P, Harrison, NA, Voon, V. Compulsivity across the pathological misuse of drug and non-drug rewards. Front Behav Neurosci. 2016;10:154.Google Scholar
Dingemans, AE, Visser, H, Paul, L, et al. Set-shifting abilities, mood and loss of control over eating in binge eating disorder: an experimental study. Psychiatry Res. 2015;230(2):242248.Google Scholar
Zastrow, A, Kaiser, S, Stippich, C, et al. Neural correlates of impaired cognitive-behavioral flexibility in anorexia nervosa. Am J Psychiatry. 2009;166(5):608616.Google Scholar
Fitzpatrick, KK, Darcy, A, Colborn, D, et al. Set-shifting among adolescents with anorexia nervosa. Int J Eat Disord. 2012;45:909912.Google Scholar
Everitt, BJ, Robbins, TW. Neural systems of reinforcement for drug addiction: from actions to habits to compulsion. Nat Neurosci. 2005;8:14811489.Google Scholar
Everitt, BJ, Belin, D, Economidou, D, et al. Neural mechanisms underlying the vulnerability to develop compulsive drug-seeking habits and addiction. Philos Trans R Soc Lond B Biol Sci. 2008;363(1507):31253135.CrossRefGoogle ScholarPubMed
Belin, D, Everitt, BJ. Cocaine seeking habits depend upon dopamine-dependent serial connectivity linking the ventral with the dorsal striatum. Neuron. 2008;57:432441.Google Scholar
Willuhn, I, Burgeno, LM, Everitt, BJ, et al. Hierarchical recruitment of phasic dopamine signaling in the striatum during the progression of cocaine use. Proc Natl Acad Sci USA. 2012;109:2070320708.Google Scholar
Sjoerds, Z, de Wit, S, van den Brink, W, et al. Behavioral and neuroimaging evidence for overreliance on habit learning in alcohol-dependent patients. Transl Psychiatry. 2013;3:e337.CrossRefGoogle ScholarPubMed
Gillan, CM, Papmeyer, M, Morein–Zamir, S, et al. Disruption in the balance between goal–directed behavior and habit learning in obsessive–compulsive disorder. Am J Psychiatry. 2011;168(7):718726.CrossRefGoogle ScholarPubMed
Gillan, CM, Morein-Zamir, S, Urcelay, GP, et al. Enhanced avoidance habits in obsessive–compulsive disorder. Biol Psychiatry. 2014;75(8):631638.Google Scholar
Voon, V, Derbyshire, K, Ruck, C, et al. Disorders of compulsivity: a common bias towards learning habits. Mol Psychiatry. 2015;20(3):345352.Google Scholar
LeBeau, RT, Mischel, ER, Simpson, HB, et al. Preliminary assessment of obsessive–compulsive spectrum disorder scales for DSM-5. J Obsess Compuls Relat Disord. 2013;2(2):114118.Google Scholar
Sternberger, LG, Burns, GL. Obsessions and compulsions: psychometric properties of the Padua Inventory with an American college population. Behav Res Ther. 1990;28(4):341345.Google Scholar
Carver, CS, White, TL. Behavioral inhibition, behavioral activation, and affective responses to impending reward and punishment: the BIS/BAS Scales. J Personality Social Psychol. 1994;67(2):319333.Google Scholar
Torrubia, R, Avila, C, Molto, J, et al. The Sensitivity to Punishment and Sensitivity to Reward Questionnaire (SPRSQ) as a measure of Gray’s anxiety and impulsivity dimensions. Personality Individual Diff. 2001;31(6):837862.Google Scholar
Meda, SA, Stevens, MC, Potenza, MN, et al. Investigating the behavioral constructs of impulsivity domains using principal component analysis. Behav Pharmacol. 2009;20:390399.Google Scholar
Andrews, MA, Meda, SA, Thomas, AD, et al. Individuals family history positive for alcoholism show fMRI abnormalities in reward sensitivity that are related to impulsivity factors. Biol Psychiatry. 2011; 69:675683.Google Scholar
Gillan, CM, Fineberg, NA, Robbins, TW. A trans-diagnostic perspective on obsessive-compulsive disorder. Psychol Med. 2017;47(9):15281548.Google Scholar
Figee, M., Booij, J., Denys, D. Molecular imaging of obsessive compulsive disorder. In: Shenton, ME, Turetsky, BI, eds. Understanding Neuropsychiatric Disorders: Insights from Neuroimaging. Cambridge University Press; 2010:260273.Google Scholar
Brambilla, F, Bellodi, L, Perna, G, et al. Dopamine function in obsessive–compulsive disorder: growth hormone response to apomorphine stimulation. Biol Psychiatry. 1997;42(10):889897.Google Scholar
Volkow, ND, Fowler, JS, Wang, GJ, et al. Imaging dopamine’s role in drug abuse and addiction. Neuropharmacology. 2009;56(Suppl 1):38.Google Scholar
Wang, GJ, Volkow, ND, Logan, J, et al. Brain dopamine and obesity. Lancet. 2001;357(9253):354357.Google Scholar
De Weijer, BA, van de Giessen, E, van Amelsvoort, TA, et al. Lower striatal dopamine D2/3 receptor availability in obese compared with non-obese subjects. EJNMMI Res. 2011;16:37.Google Scholar
Ersche, KD, Roiser, JP, Abbott, S, et al. Response perseveration in stimulant dependence is associated with striatal dysfunction and can be ameliorated by a D(2/3) receptor agonist. Biol Psychiatry. 2011;70(8):754762.Google Scholar
Eagle, DM, Noschang, C, d’Angelo, LS, et al. The dopamine D2/D3 receptor agonist quinpirole increases checking-like behaviour in an operant observing response task with uncertain reinforcement: a novel possible model of OCD. Behav Brain Res. 2014;264:207229.Google Scholar
Vulink, NC, Figee, M, Denys, D. Review of atypical antipsychotics in anxiety. Eur Neuropsychopharmacol. 2011;21(6):429449.Google Scholar
Frank, GK, Shott, ME, Hagman, JO, et al. The partial dopamine D2 receptor agonist aripiprazole is associated with weight gain in adolescent anorexia nervosa. Int J Eat Disord. 2017;50(4):447450.Google Scholar
Feltenstein, MW, Altar, CA, See, RE. Aripiprazole blocks reinstatement of cocaine seeking in an animal model of relapse. Biol Psychiatry. 2007;61(5):582590.Google Scholar
Citrome, L. Lisdexamfetamine for binge eating disorder in adults: a systematic review of the efficacy and safety profile for this newly approved indication – what is the number needed to treat, number needed to harm and likelihood to be helped or harmed? Int J Clin Pract. 2015;69(4):410421.Google Scholar
Hudson, JI, McElroy, SL, Ferreira-Cornwell, MC, et al. Efficacy of lisdexamfetamine in adults with moderate to severe binge-eating disorder: a randomized clinical trial. JAMA Psychiatry. 2017;74(9):903910.Google Scholar
Pelloux, Y, Dilleen, R, Economidou, D, et al. Reduced forebrain serotonin transmission is causally involved in the development of compulsive cocaine seeking in rats. Neuropsychopharmacology. 2012; 37(11):25052514.Google Scholar
Joel, D, Ben-Amir, E, Doljansky, J, et al. “Compulsive” lever-pressing in rats is attenuated by the serotonin re-uptake inhibitors paroxetine and fluvoxamine but not by the tricyclic antidepressant desipramine or the anxiolytic diazepam. Behav Pharmacol. 2004;15:241252.CrossRefGoogle ScholarPubMed
Clarke, HF, Dalley, JW, Crofts, HS, Robbins, TW, Roberts, AC. Cognitive inflexibility after prefrontal serotonin depletion. Science. 2004;304:878880.CrossRefGoogle ScholarPubMed
Barlow, RL, Alsiö, J, Jupp, B, et al. Markers of serotonergic function in the orbitofrontal cortex and dorsal raphé nucleus predict individual variation in spatial-discrimination serial reversal learning. Neuropsychopharmacology. 2015;40(7):16191630.Google Scholar
Fineberg, NA, Brown, A, Reghunandanan, SP, et al. Evidence-based pharmacotherapy of obsessive-compulsive disorder. Int J Neuropsychopharmacol. 2012;15:11731191.Google Scholar
Hay, PJ, Claudino, AM. Clinical psychopharmacology of eating disorders: a research update. Int J Neuropsychopharmacol. 2012;15(2):209222.Google Scholar
Brockmeyer, T, Walther, S, Ingenerf, K, et al. Brain effects of computer-assisted cognitive remediation therapy in anorexia nervosa: a pilot fMRI study. Psychiatry Res. 2016;249:5256.CrossRefGoogle ScholarPubMed
Goodman, A. Neurobiology of addiction. An integrative review. Biochem Pharmacol. 2008;75(1):266322.Google Scholar
Vlachou, S, Markou, A. GABAB receptors in reward processes. Adv Pharmacol. 2010;58:315371.Google Scholar
Filip, M, Frankowska, M, Sadakierska-Chudy, A, et al. GABA-B receptors as a therapeutic strategy in substance use disorders: focus on positive allosteric modulators. Neuropharmacology. 2015;88C:3647.Google Scholar
Russo, AJ, Pietsch, SC. Decreased hepatocyte growth factor (HGF) and gamma aminobutyric acid (GABA) in individuals with obsessive–compulsive disorder (OCD). Biomark Insights. 2013;8:107114.Google Scholar
Simpson, HB, Shungu, DC, Bender, J Jr, et al. Investigation of cortical glutamate–glutamine and γ-aminobutyric acid in obsessive–compulsive disorder by proton magnetic resonance spectroscopy. Neuropsychopharmacology. 2012;37(12):26842692.Google Scholar
Burguiere, E, Monteiro, P, Feng, G, et al. Optogenetic stimulation of lateral orbitofronto-striatal pathway suppresses compulsive behaviors. Science. 2013;340:12431246.Google Scholar
Xie, Y, Heida, T, Stegenga, J. High-frequency electrical stimulation suppresses cholinergic accumbens interneurons in acute rat brain slices through GABAB receptors. Eur J Neurosci. 2014;40(11):36533662.Google Scholar
Arnsten, AF, Wang, M, Paspalas, CD. Dopamine’s actions in primate prefrontal cortex: challenges for treating cognitive disorders. Pharmacol Rev. 2015;67(3):681696.Google Scholar
Wu, K, Hanna, GL, Rosenberg, DR, et al. The role of glutamate signaling in the pathogenesis and treatment of obsessive–compulsive disorder. Pharmacol Biochem Behav. 2012;100(4):726735.Google Scholar
McCracken, CB, Grace, AA. High-frequency deep brain stimulation of the nucleus accumbens region suppresses neuronal activity and selectively modulates afferent drive in rat orbitofrontal cortex in vivo. J Neurosci. 2007;27:1260112610.Google Scholar
Yan, N, Chen, N, Zhu, H, et al. High-frequency stimulation of nucleus accumbens changes in dopaminergic reward circuit. PloS One. 2013;8(11):e79318.Google Scholar
Rodriguez, CI, Kegeles, LS, Levinson, , et al. Randomized controlled crossover trial of ketamine in obsessive–compulsive disorder: proof-of-concept. Neuropsychopharmacology. 2013;38(12):24752483.Google Scholar
Van Huijstee, AN, Mansvelder, HD. Glutamatergic synaptic plasticity in the mesocorticolimbic system in addiction. Front Cell Neurosci. 2015;8:466.Google Scholar
Pettorruso, M, De Risio, L, Martinotti, GD, et al. Targeting the glutamatergic system to treat pathological gambling: current evidence and future perspectives. BioMed Res Int. 2014;109786.Google Scholar
Berlin, HA, Koran, LM, Jenike, MA, et al. Double-blind, placebo-controlled trial of topiramate augmentation in treatment-resistant obsessive-compulsive disorder. J Clin Psychiatry. 2011;72(5):716721.Google Scholar
Aboujaoude, E, Barry, JJ, Gamel, N. Memantine augmentation in treatment-resistant obsessive-compulsive disorder: an open-label trial. J Clin Psychopharmacol. 2009;29(1):51–5.Google Scholar
Pettorruso, M, De Risio, L, Martinotti, G, et al. Targeting the glutamatergic system to treat pathological gambling: current evidence and future perspectives. Biomed Res Int. 2014;2014:109786.Google Scholar
Grant, JE, Odlaug, BL, Kim, SW. N-acetylcysteine, a glutamate modulator, in the treatment of trichotillomania: a double-blind, placebo-controlled study. Arch Gen Psychiatry. 2009;66(7):756763.Google Scholar
Grant, JE, Chamberlain, SR, Redden, SA, et al. N-Acetylcysteine in the treatment of excoriation disorder: a randomized clinical trial. JAMA Psychiatry. 2016;73(5):490496.Google Scholar
Oliver, G, Dean, O, Camfield, D, et al. N-acetyl cysteine in the treatment of obsessive compulsive and related disorders: a systematic review. Clin Psychopharmacol Neurosci. 2015;13(1):1224.Google Scholar
Nocito Echevarria, MA, Andrade Reis, T, Ruffo Capatti, G, et al. N-acetylcysteine for treating cocaine addiction – a systematic review. Psychiatry Res. 2017;251:197203.Google Scholar
Dunlop, K, Woodside, B, Olmsted, M, et al. Reductions in cortico-striatal hyperconnectivity accompany successful treatment of obsessive-compulsive disorder with dorsomedial prefrontal rTMS. Neuropsychopharmacology. 2016;41(5):13951403.Google Scholar
De Ridder, D, Vanneste, S, Kovacs, , et al. Transient alcohol craving suppression by rTMS of dorsal anterior cingulate: an fMRI and LORETA EEG study. Neurosci Lett. 2011;496:510.Google Scholar
Valencia-Alfonso, CE, Luigjes, J, Smolders, R, et al. Effective deep brain stimulation in heroin addiction: a case report with complementary intracranial electroencephalogram. Biol Psychiatry. 2012;71(8):e35e37.Google Scholar
Mantione, M, van de Brink, W, Schuurman, PR, et al. Smoking cessation and weight loss after chronic deep brain stimulation of the nucleus accumbens: therapeutic and research implications: case report. Neurosurgery. 2010;66(1):E218.Google Scholar
Graat, I, Figee, M, Denys, D. The application of deep brain stimulation in the treatment of psychiatric disorders. Int Rev Psychiatry. 2017;29(2):178190.Google Scholar
Foldi, CJ, Milton, LK, Oldfield, BJ. The role of mesolimbic reward neurocircuitry in prevention and rescue of the activity-based anorexia (ABA) phenotype in rats. Neuropsychopharmacology. 2017;42(12):22922300.Google Scholar
Mundt, A, Klein, J, Joel, D, et al. High-frequency stimulation of the nucleus accumbens core and shell reduces quinpirole-induced compulsive checking in rats. Eur J Neurosci. 2009;29(12):24012412.Google Scholar
Winter, C, Mundt, A, Jalali, R, et al. High frequency stimulation and temporary inactivation of the subthalamic nucleus reduce quinpirole-induced compulsive checking behavior in rats. Exp Neurol. 2008;210(1):217218.Google Scholar
Mallet, L, Polosan, M, Jaafari, N, et al. Subthalamic nucleus stimulation in severe obsessive-compulsive disorder. N Engl J Med. 2008;359(20):21212134.Google Scholar
Denys, D, Mantione, M, Figee, M, et al. Deep brain stimulation of the nucleus accumbens for treatment-refractory obsessive-compulsive disorder. Arch Gen Psychiatry. 2010;67(10):10611068.Google Scholar
Sesia, T, Bizup, B, Grace, AA. Evaluation of animal models of obsessive–compulsive disorder: correlation with phasic dopamine neuron activity. Int J Neuropsychopharmacol. 2013;16(6):12951307.Google Scholar
Figee, M, de Koning, P, Klaassen, S, et al. Deep brain stimulation induces striatal dopamine release in obsessive-compulsive disorder. Biol Psychiatry. 2014;75(8):647652.Google Scholar
Nuttin, B, Gielen, F, van Kuyck, K, et al. Targeting bed nucleus of the stria terminalis for severe obsessive–compulsive disorder: more unexpected lead placement in obsessive–compulsive disorder than in surgery for movement disorders. World Neurosurg. 2013;80(34):S30.e11S30.e16.Google Scholar
Raymaekers, S, Vansteelandt, K, Luyten, L, et al. Long-term electrical stimulation of bed nucleus of stria terminalis for obsessive-compulsive disorder. Mol Psychiatry. 2017;22(6):931934.Google Scholar
Blomstedt, P, Naesström, M, Bodlund, O. Deep brain stimulation in the bed nucleus of the stria terminalis and medial forebrain bundle in a patient with major depressive disorder and anorexia nervosa. Clin Case Rep. 2017;5(5):679684.Google Scholar
Luigjes, J, van den Brink, W, Feenstra, M, et al. Deep brain stimulation in addiction: a review of potential brain targets. Mol Psychiatry. 2012;17(6):572583.Google Scholar
Potenza, MN, Koran, LM, Pallanti, S. The relationship between obsessive–compulsive and impulse control disorders: a current understanding and future research directions. Psychiatry Res. 2009;170:2231.Google Scholar
Koran, LM, Aboujaoude, E, Bullock, KD. Double-blind treatment with oral morphine in treatment-resistant obsessive–compulsive disorder. J Clin Psychiatry. 2005;66(3):353359.Google Scholar
Oudijn, MS, Storosum, JG, Nelis, E, et al. Is deep brain stimulation a treatment option for anorexia nervosa? BMC Psychiatry. 2013;13:277.Google Scholar
Kravitz, AV, Tomasi, D, LeBlanc, KH, et al. Cortico-striatal circuits: novel therapeutic targets for substance use disorders. Brain Res. 2015;1628(Pt A):186198.Google Scholar

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