The chapter shows how classical interpolation problems of various types (Schur, Nevanlinna–Pick, Hermite–Fejer) carry over and generalize to the time-variant and/or matrix situation. We show that they all reduce to a single generalized constrained interpolation problem, elegantly solved by time-variant scattering theory. An essential ingredient is the definition of the notion of valuation for time-variant systems, thereby generalizing the notion of valuation in the complex plane provided by the classical z-transform.