We use cookies to distinguish you from other users and to provide you with a better experience on our websites. Close this message to accept cookies or find out how to manage your cookie settings.
We use cookies to distinguish you from other users and to provide you with a better experience on our websites. Close this message to accept cookies or find out how to manage your cookie settings.
Published online by Cambridge University Press: 09 December 2021
Injection of solutes such as Na+ or mannitol, which initially elevate ECF osmotic pressure and then draw water from cells to dilute the load to near isotonicity, causes reliable drinking in all species studied. This osmoregulatory drinking is accompanied by report of thirst in humans and secretion of AVP. The threshold elevation of systemic osmolality to initiate these changes is in the range 1–3%. Regardless of whether drinking is allowed, the osmotic load is excreted by the kidney over the course of2–4 hours. From sham drinking and other studies, osmoregulatory drinking is satiated when osmotic pressure is normalized and cellular water is restored. Many studies have shown that osmoreceptors for drinking and AVP secretion are located in or near the CVOs of the lamina terminalis. In addition, peripheral osmoreceptors in the gut or splanchnic regions monitor the osmolality of fluids absorbed from the gut and are sufficient to stimulate drinking in the absence of systemic hyperosmolality.
To save this book to your Kindle, first ensure [email protected] is added to your Approved Personal Document E-mail List under your Personal Document Settings on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part of your Kindle email address below. Find out more about saving to your Kindle.
Note you can select to save to either the @free.kindle.com or @kindle.com variations. ‘@free.kindle.com’ emails are free but can only be saved to your device when it is connected to wi-fi. ‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.
Find out more about the Kindle Personal Document Service.
To save content items to your account, please confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account. Find out more about saving content to Dropbox.
To save content items to your account, please confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account. Find out more about saving content to Google Drive.
