This essay interprets Erwin Panofsky’s Gothic Architecture and Scholasticism of 1951 by situating the book within the Marburgian tradition of neo-Kantian philosophy. To do so, Panofsky’s relation to Marburgian neo-Kantianism is first contextualized and explicated, specifically by way of his well-known relationship to Ernst Cassirer and his own programmatic statements about art historical method. With this foundation in place, Panofsky’s specific claims in Gothic Architecture and Scholasticism are positioned as an attempted art-historical translation of the Marburgian commitment to ground knowledge on underlying structures of knowledge. Panofsky’s effort in this regard is shown to relate to nomological traditions of scholarship, wherein covering laws are an express and essential aim of research. Interpreting Panofsky’s argument in this way helps clarify the book’s uneven reception in the humanities, wherein an ideographic approach focusing on historical specificity for its own sake is a more accepted norm.