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7 - Biocolloid Rheology

Published online by Cambridge University Press:  07 April 2021

By
Surita Bhatia  and
Wendy Hom
Edited by
Norman J. Wagner  and
Jan Mewis
Norman J. Wagner
Affiliation:
University of Delaware
Jan Mewis
Affiliation:
KU Leuven, Belgium
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Summary

This chapter applies the fundamental framework for colloidal forces and rheology to biocolloids. We define biocolloids broadly as colloidal assemblies with primary applications that are biomedical in nature, e.g., (i) block copolymers used in pharmaceutical formulations and biomaterials applications, and (ii) biomacromolecules that can be reasonably described with colloidal descriptions for the interparticle interactions; namely globular proteins and protein assemblies such as casein micelles. Our discussion mainly focuses on systems where concepts from colloidal interactions prove useful in interpreting the rheological behavior. The chapter briefly discusses the importance of colloidal rheology to applications in drug delivery, biomolecular therapeutics, and foods. Examples from both classic publications and recent literature are provided, along with models to describe the rheological behavior. Specific systems discussed include thermoresponsive micellar block copolymers, associative polymers, biomimetic block copolymer assemblies with stereocomplexes and crystalline domains as well as globular proteins.

Keywords

rheologybiocolloidssuspensionsreviewproteinsmicelles
Type
Chapter
Information
Theory and Applications of Colloidal Suspension Rheology , pp. 291 - 315
Publisher: Cambridge University Press
Print publication year: 2021

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