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Chapter 19 - The Thalamus and Sleep

from Section 8: - Arousal

Published online by Cambridge University Press:  12 August 2022

By
Mattia Aime  and
Antoine R. Adamantidis
Edited by
Michael M. Halassa
Michael M. Halassa
Affiliation:
Massachusetts Institute of Technology
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Summary

The architecture of the thalamus and its reciprocal connections with multiple cortical and subcortical structures are essential to the generation of the thalamo-cortical network oscillations associated with attention, sleep, and consciousness. This chapter provides an overview of the cellular mechanisms underlying thalamo-cortical network oscillations occurring during sleep and their contribution to the architecture of the sleep–wake cycle, including the onset and stability of non–rapid eye movement (NREM) and rapid eye movement (REM) sleep. It further summarizes the influence of the brainstem neuromodulatory system on thalamo-cortical network activity during wakefulness and sleep. Finally, the association between these mechanisms and synaptic plasticity in thalamo-cortical networks is described in the context of sleep-dependent consolidation, or weakening, of previously acquired information in health and disease.

Keywords

NREM sleepREM sleepthalalmuscortexoscillationsneuromodulationsynaptic plasticity
Type
Chapter
Information
The Thalamus , pp. 361 - 381
Publisher: Cambridge University Press
Print publication year: 2022

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