Skip to main content Accessibility help
×
Hostname: page-component-78c5997874-s2hrs Total loading time: 0 Render date: 2024-11-19T14:43:07.321Z Has data issue: false hasContentIssue false

Chapter 9 - Be Aware, Unaware and Confusion Everywhere

TIVA and Awareness

Published online by Cambridge University Press:  18 November 2019

Michael G. Irwin
Affiliation:
The University of Hong Kong
Gordon T. C. Wong
Affiliation:
The University of Hong Kong
Shuk Wan Lam
Affiliation:
The University of Hong Kong
Get access

Summary

All anaesthetists need to be skilled in the administration of IV anaesthesia, yet evidence from the 5th National Audit Project (NAP5) of the Royal College of Anaesthetists and the Association of Anaesthetists of Great Britain and Ireland documenting cases of accidental awareness during general anaesthesia (AAGA) suggests that this might not be the case. TIVA is used in only 7% of cases, with preponderance for certain surgical operations such as those on the airway where administration of an inhaled anaesthetic is not feasible. Conversely, TIVA has been almost completely avoided in other types of surgery such as Caesarean sections, at least in the UK and Ireland. TIVA is also used for transfer of patients and in remote areas that do not have the equipment required to deliver inhaled anaesthesia. For the purpose of this discussion, it should be clarified from the outset that there are several modes of TIVA delivery. The majority is target-controlled infusion (TCI), carried out with dedicated PK pumps and used in ~5% of all cases or ~81% of TIVA cases. The most basic is manual boluses of propofol using a hand-held syringe: the anaesthetist simply injects the amount they judge necessary to maintain anaesthesia (0.7% of all UK cases, or ~10% of all TIVA cases). The third is non-TCI infusions, which constitute ~0.6% of all cases, or ~9% of TIVA cases. However, there is some international geographic variation in this practice, because in the United States TCI remains unlicensed and therefore seldom used.

Type
Chapter
Information
Taking on TIVA
Debunking Myths and Dispelling Misunderstandings
, pp. 63 - 72
Publisher: Cambridge University Press
Print publication year: 2019

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Sandin, R.H., Enlund, G., Samuelsson, P., Lennmarken, C.. Awareness during anaesthesia: a prospective case study. Lancet 2000; 355: 707–11.Google ScholarPubMed
Nordstrom, O., Engstrom, A.M., Persson, S., Sandin, R.. Incidence of awareness in total i.v. anaesthesia based on propofol, alfentanil and neuromuscular blockade. Acta Anaesthesiol Scand 1997; 41: 978–84.CrossRefGoogle ScholarPubMed
Errando, C.L., Sigl, J.C., Robles, M., et al. Awareness with recall during general anaesthesia: a prospective observational evaluation of 4001 patients. Br J Anaesth 2008; 101: 178–85.CrossRefGoogle ScholarPubMed
Morimoto, T., Sakuma, M., Matsui, K., et al. Incidence of adverse drug events and medication errors in Japan: the JADE study. J Gen Intern Med 2011; 26: 148–53.CrossRefGoogle ScholarPubMed
Pandit, JJ, Andrade, J, Bogod, DG, et al. 5th National Audit Project (NAP5) on accidental awareness during general anaesthesia: summary of main findings and risk factors. Anaesthesia 2014; 69: 1089–101.Google Scholar
Nimmo, A.F., Absalom, A.R., Bagshaw, O., et al. Guidelines for the safe practice of total intravenous anaesthesia (TIVA): joint guidelines from the Association of Anaesthetists and the Society for Intravenous Anaesthesia. Anaesthesia 2019; 74: 211–44.CrossRefGoogle Scholar
Irwin, M.G., Wong, G.T.C.. Taking on TIVA. Why we need guidelines on total intravenous anaesthesia. Anaesthesia 2019; 74: 140–2.CrossRefGoogle Scholar
Hardman, J.G.A., Aitkenhead, A.R.. Awareness during anaesthesia. Continuing Education in Anaesthesia Critical Care & Pain 2005; 5: 183–6.CrossRefGoogle Scholar
Tammisto, T., Tigerstedt, I.. The need for halothane supplementation of N2O–O2-relaxant anaesthesia in chronic alcoholics. Acta Anaesthesiol Scand 1977; 21: 1723.CrossRefGoogle ScholarPubMed
Xu, R., Zhou, S., Yang, J., et al. Total intravenous anesthesia produces outcomes superior to those with combined intravenous-inhalation anesthesia for laparoscopic gynecological surgery at high altitude. J Int Med Res 2017; 45: 246–53.Google Scholar
Hajat, Z., Ahmad, N., Andrzejowski, J.. The role and limitations of EEG-based depth of anaesthesia monitoring in theatres and intensive care. Anaesthesia 2017; 72 Suppl 1 3847.CrossRefGoogle ScholarPubMed
Engbers, F.H.M.. Basic pharmacokinetic principles for intravenous anaesthesia. In: Vuyk, J. and Schraag, S. eds. Advances in Modelling and Clinical Application of Intravenous Anaesthesia. Boston, MA: Springer US, 2003: 318.CrossRefGoogle Scholar
Gambus, P.L., Troconiz, I.F.. Pharmacokinetic–pharmacodynamic modelling in anaesthesia. Br J Clin Pharmacol 2015; 79: 7284.CrossRefGoogle ScholarPubMed
Absalom, A.R., Mani, V., De Smet, T., Struys, M.M.. Pharmacokinetic models for propofol: defining and illuminating the devil in the detail. Br J Anaesth 2009; 103: 2637.Google Scholar
Marsh, B., White, M., Morton, N., Kenny, G.N.. Pharmacokinetic model driven infusion of propofol in children. Br J Anaesth 1991; 67: 41–8.CrossRefGoogle ScholarPubMed
Minto, C.F., Schnider, T.W., Egan, T.D., et al. Influence of age and gender on the pharmacokinetics and pharmacodynamics of remifentanil. I. Model development. Anesthesiology 1997; 86: 1023.CrossRefGoogle ScholarPubMed
Schnider, T.W., Minto, C.F., Gambus, P.L., et al. The influence of method of administration and covariates on the pharmacokinetics of propofol in adult volunteers. Anesthesiology 1998; 88: 1170–82.CrossRefGoogle ScholarPubMed
Schnider, T.W., Minto, C.F., Shafer, S.L., et al. The influence of age on propofol pharmacodynamics. Anesthesiology 1999; 90: 1502–16.CrossRefGoogle ScholarPubMed
Al-Rifai, Z., Mulvey, D.. Principles of total intravenous anaesthesia: practical aspects of using total intravenous anaesthesia. BJA Education 2016; 16: 276–80.Google Scholar
Avidan, M.S., Mashour, G.A.. Prevention of intraoperative awareness with explicit recall making sense of the evidence. Anesthesiology 2013; 118: 449–56.Google Scholar
Mashour, G.A., Shanks, A., Tremper, K.K., et al. Prevention of intraoperative awareness with explicit recall in an unselected surgical population. A randomized comparative effectiveness trial. Anesthesiology 2012; 117: 717–25.CrossRefGoogle Scholar
Bruhn, J., Myles, P.S., Sneyd, R., Struys, M.M.R.F.. Depth of anaesthesia monitoring: what’s available, what’s validated and what’s next? Br J Anaesth 2006; 97: 8594.Google Scholar
Jensen, E.W., Gambus, P.L., Valencia, J.F., et al. Validation of the qNOX Pain/Nociception Index for monitoring loss of response to tetanic stimulation during general anaesthesia. Anesthesiology 2013; 119.Google Scholar
Jensen, E.W., Valencia, J.F., Lopez, A., et al. Monitoring hypnotic effect and nociception with two EEG-derived indices, qCON and qNOX, during general anaesthesia. Acta Anaesthesiol Scand 2014; 58: 933–41.Google Scholar
Wu, G., Zhang, L., Wang, X., Yu, A., Zhang, Z., Yu, J.. Effects of indexes of consciousness (IoC1 and IoC2) monitoring on remifentanil dosage in modified radical mastectomy: a randomized trial. Trials 2016; 17: 167.Google Scholar
Kirschstein, T., Kohling, R.. What is the source of the EEG? Clin EEG Neurosci 2009; 40: 146–9.CrossRefGoogle ScholarPubMed
Rampil, I.J.. A primer for EEG signal processing in anesthesia. Anesthesiology 1998; 89: 9801002.Google Scholar
Kortelainen, J., Koskinen, M., Mustola, S., Seppanen, T.. EEG spectral changes and onset of burst suppression pattern in propofol/remifentanil anesthesia. Conf Proc IEEE Eng Med Biol Soc 2008; 2008: 4980–3.Google ScholarPubMed
Kortelainen, J., Koskinen, M., Mustola, S., Seppanen, T.. Effects of remifentanil on the spectrum and quantitative parameters of electroencephalogram in propofol anesthesia. Anesthesiology 2009; 111: 574–83.CrossRefGoogle ScholarPubMed
Pilge, S., Kreuzer, M., Karatchiviev, V., Kochs, E.F., Malcharek, M., Schneider, G.. Differences between state entropy and bispectral index during analysis of identical electroencephalogram signals: a comparison with two randomised anaesthetic techniques. Eur J Anaesthesiol 2015; 32: 354–65.CrossRefGoogle ScholarPubMed
Aho, A.J., Kamata, K., Jantti, V., et al. Comparison of bispectral index and entropy values with electroencephalogram during surgical anaesthesia with sevoflurane. Br J Anaesth 2015; 115: 258–66.CrossRefGoogle ScholarPubMed
Muller, J.N., Kreuzer, M., Garcia, P.S., Schneider, G., Hautmann, H.. Monitoring depth of sedation: evaluating the agreement between the bispectral index, qCON and the entropy module’s state entropy during flexible bronchoscopy. Minerva Anestesiol 2017; 83: 563–73.Google Scholar
Ellerkmann, R.K., Kreuer, S., Wilhelm, W., et al. The correlation of the bispectral index with propofol effect site concentrations is not altered by epochs indicated as artefact-loaded by narcotrend. J Clin Monit Comput 2004; 18: 283–7.Google Scholar
Rigouzzo, A., Girault, L., Louvet, N., et al. The relationship between bispectral index and propofol during target-controlled infusion anesthesia: a comparative study between children and young adults. Anesth Analg 2008; 106: 1109–16.CrossRefGoogle ScholarPubMed
Mashour, G.A., Shanks, A., Tremper, K.K., et al. Prevention of intraoperative awareness with explicit recall in an unselected surgical population: a randomized comparative effectiveness trial. Anesthesiology 2012; 117: 717–25.Google Scholar
Zhang, C., Xu, L., Ma, Y.Q., et al. Bispectral index monitoring to prevent awareness during total intravenous anesthesia: a prospective, randomized, double-blinded, multi-center controlled trial. Chin Med J 2011; 124: 3664–9.Google ScholarPubMed
Ekman, A., Lindholm, M.L., Lennmarken, C., Sandin, R.. Reduction in the incidence of awareness using BIS monitoring. Acta Anaesthesiol Scand 2004; 48: 20–6.CrossRefGoogle ScholarPubMed
Myles, P.S., Leslie, K., McNeil, J., Forbes, A., Chan, M.T.. Bispectral index monitoring to prevent awareness during anaesthesia: the B-Aware randomised controlled trial. Lancet 2004; 363: 1757–63.Google Scholar
Chan, M.T., Cheng, B.C., Lee, T.M., Gin, T., Group, C.T.. BIS-guided anesthesia decreases postoperative delirium and cognitive decline. J Neurosurg Anesthesiol 2013; 25: 3342.Google Scholar
Yli-Hankala, A., Vakkuri, A., Annila, P., Korttila, K.. EEG bispectral index monitoring in sevoflurane or propofol anaesthesia: analysis of direct costs and immediate recovery. Acta Anaesthesiol Scand 1999; 43: 545–9.Google Scholar
Vakkuri, A., Yli-Hankala, A., Sandin, R., et al. Spectral entropy monitoring is associated with reduced propofol use and faster emergence in propofol-nitrous oxide-alfentanil anesthesia. Anesthesiology 2005; 103: 274–9.CrossRefGoogle ScholarPubMed
Riad, W., Schreiber, M., Saeed, A.B.. Monitoring with EEG entropy decreases propofol requirement and maintains cardiovascular stability during induction of anaesthesia in elderly patients. Eur J Anaesthesiol 2007; 24: 684–8.Google Scholar
Gan, T.J., Glass, P.S., Windsor, A., et al. Bispectral index monitoring allows faster emergence and improved recovery from propofol, alfentanil, and nitrous oxide anesthesia. BIS Utility Study Group. Anesthesiology 1997; 87: 808–15.Google Scholar
Luginbuhl, M., Wuthrich, S., Petersen-Felix, S., Zbinden, A.M., Schnider, T.W.. Different benefit of bispectal index (BIS) in desflurane and propofol anesthesia. Acta Anaesthesiol Scand 2003; 47: 165–73.CrossRefGoogle ScholarPubMed
Berger, M., Nadler, J.W., Browndyke, J., et al. Postoperative cognitive dysfunction: minding the gaps in our knowledge of a common postoperative complication in the elderly. Anesthesiol Clin 2015; 33: 517–50.Google Scholar
Rundshagen, I.. Postoperative cognitive dysfunction. Dtsch Arztebl Int 2014; 111: 119–25.Google Scholar
Bedford, P.D.. Adverse cerebral effects of anaesthesia on old people. Lancet 1955; 269: 259–63.Google Scholar
Radtke, F.M., Franck, M., Lendner, J., Kruger, S., Wernecke, K.D., Spies, C.D.. Monitoring depth of anaesthesia in a randomized trial decreases the rate of postoperative delirium but not postoperative cognitive dysfunction. Br J Anaesth 2013; 110 Suppl 1: i98105.CrossRefGoogle Scholar
Sieber, F.E., Zakriya, K.J., Gottschalk, A., et al. Sedation depth during spinal anesthesia and the development of postoperative delirium in elderly patients undergoing hip fracture repair. Mayo Clin Proc 2010; 85: 1826.Google Scholar
Whitlock, E.L., Torres, B.A., Lin, N., et al. Postoperative delirium in a substudy of cardiothoracic surgical patients in the BAG-RECALL clinical trial. Anesth Analg 2014; 118: 809–17.Google Scholar
Luginbühl, M., Schumacher, P.M., Vuilleumier, P., et al. Noxious stimulation response index. A novel anesthetic state index based on hypnotic–opioid interaction. Anesthesiology 2010; 112: 872–80.Google Scholar
Ledowski, T., Tiong, W. S., Lee, C., Wong, B., Fiori, T., Parker, N., Analgesia nociception index: evaluation as a new parameter for acute postoperative pain. Br J Anaesth 2013; 111:4, 627–9.Google Scholar
Monk, T.G., Weldon, B.C.. Does depth of anesthesia monitoring improve postoperative outcomes? Curr Opin Anaesthesiol 2011; 24: 665–9.Google Scholar
Maksimow, A., Sarkela, M., Langsjo, J.W., et al. Increase in high frequency EEG activity explains the poor performance of EEG spectral entropy monitor during S-ketamine anesthesia. Clin Neurophysiol 2006; 117: 1660–8.Google Scholar
Sakai, T., Singh, H., Mi, W.D., Kudo, T., Matsuki, A.. The effect of ketamine on clinical endpoints of hypnosis and EEG variables during propofol infusion. Acta Anaesthesiol Scand 1999; 43: 212–16.Google Scholar
Rampil, I.J., Kim, J.S., Lenhardt, R., Negishi, C., Sessler, D.I.. Bispectral EEG index during nitrous oxide administration. Anesthesiology 1998; 89: 671–7.Google Scholar
Pandit, JJ, Cook, TM. National Institute for Clinical Excellence guidance on measuring depth of anaesthesia: limitations of EEG-based technology. Br J Anaesth 2013; 110: 325–8.Google Scholar

Save book to Kindle

To save this book to your Kindle, first ensure [email protected] is added to your Approved Personal Document E-mail List under your Personal Document Settings on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part of your Kindle email address below. Find out more about saving to your Kindle.

Note you can select to save to either the @free.kindle.com or @kindle.com variations. ‘@free.kindle.com’ emails are free but can only be saved to your device when it is connected to wi-fi. ‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.

Find out more about the Kindle Personal Document Service.

Available formats
×

Save book to Dropbox

To save content items to your account, please confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account. Find out more about saving content to Dropbox.

Available formats
×

Save book to Google Drive

To save content items to your account, please confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account. Find out more about saving content to Google Drive.

Available formats
×