This chapter covers both the practice of embryo donation, the ethical and legal aspects, whether for reproductive purpose or for research. It outlines the general principles and ethical questions surrounding gamete/embryo donation. Two main controversial issues for gamete(s) or embryo donation are anonymity and payment. With the conviction that the human body and its parts and products should remain outside commerce, one can attempt a rational argument in the realm of ethics, for altruistic donation. The technique of embryo donation is very simple: it is a frozen embryo transfer (FET), where the embryo originated from another couple and not the woman who is having the implantation. This can be performed in either a hormone replacement therapy (HRT) cycle, or in a natural cycle. Emotionally, donating embryos is a difficult decision, which certainly challenges the notion of genetic relatedness, especially when it is for another couple's reproductive plans.