A clearly formulated research question is vital in science because it determines the data we need to collect, the methods we use, and, ultimately, the success of a project. Developing a research question is an iterative process of reading and thinking, as we define a problem and specify the contribution we hope to make to resolving it. This is not easy, and we learn through experience, and (if we’re lucky) from our mentors. In this chapter I first explain research questions and the case studies we use to address them, then look at where questions come from. I examine what makes a good research question and end with why reading is essential to the development of research ideas