Book contents
- Stahl’s Essential Psychopharmacology
- Additional material
- Stahl’s Essential Psychopharmacology
- Copyright page
- Contents
- Preface to the Fifth Edition
- CME Information
- 1 Chemical Neurotransmission
- 2 Transporters, Receptors, and Enzymes as Targets of Psychopharmacological Drug Action
- 3 Ion Channels as Targets of Psychopharmacological Drug Action
- 4 Psychosis, Schizophrenia, and the Neurotransmitter Networks Dopamine, Serotonin, and Glutamate
- 5 Targeting Dopamine and Serotonin Receptors for Psychosis, Mood, and Beyond: So-Called “Antipsychotics”
- 6 Mood Disorders and the Neurotransmitter Networks Norepinephrine and γ-Aminobutyric Acid (GABA)
- 7 Treatments for Mood Disorders: So-Called “Antidepressants” and “Mood Stabilizers”
- 8 Anxiety, Trauma, and Treatment
- 9 Chronic Pain and Its Treatment
- 10 Disorders of Sleep and Wakefulness and Their Treatment: Neurotransmitter Networks for Histamine and Orexin
- 11 Attention Deficit Hyperactivity Disorder and Its Treatment
- 12 Dementia: Causes, Symptomatic Treatments, and the Neurotransmitter Network Acetylcholine
- 13 Impulsivity, Compulsivity, and Addiction
- Suggested Reading and Selected References
- Index
12 - Dementia: Causes, Symptomatic Treatments, and the Neurotransmitter Network Acetylcholine
Published online by Cambridge University Press: 19 October 2021
- Stahl’s Essential Psychopharmacology
- Additional material
- Stahl’s Essential Psychopharmacology
- Copyright page
- Contents
- Preface to the Fifth Edition
- CME Information
- 1 Chemical Neurotransmission
- 2 Transporters, Receptors, and Enzymes as Targets of Psychopharmacological Drug Action
- 3 Ion Channels as Targets of Psychopharmacological Drug Action
- 4 Psychosis, Schizophrenia, and the Neurotransmitter Networks Dopamine, Serotonin, and Glutamate
- 5 Targeting Dopamine and Serotonin Receptors for Psychosis, Mood, and Beyond: So-Called “Antipsychotics”
- 6 Mood Disorders and the Neurotransmitter Networks Norepinephrine and γ-Aminobutyric Acid (GABA)
- 7 Treatments for Mood Disorders: So-Called “Antidepressants” and “Mood Stabilizers”
- 8 Anxiety, Trauma, and Treatment
- 9 Chronic Pain and Its Treatment
- 10 Disorders of Sleep and Wakefulness and Their Treatment: Neurotransmitter Networks for Histamine and Orexin
- 11 Attention Deficit Hyperactivity Disorder and Its Treatment
- 12 Dementia: Causes, Symptomatic Treatments, and the Neurotransmitter Network Acetylcholine
- 13 Impulsivity, Compulsivity, and Addiction
- Suggested Reading and Selected References
- Index
Summary
This chapter will provide a brief overview of the various causes of dementia and their pathologies, including the most recent diagnostic criteria, and how biomarkers are beginning to be integrated into clinical practice, especially for Alzheimer disease (AD). Full clinical and pathological descriptions and formal criteria for how to diagnose the numerous known dementias should be obtained by consulting standard reference sources. The discussion here will emphasize how various pathological mechanisms in different dementias disrupt brain circuits and their neurotransmitters. We will also show how disruption of these brain circuits is linked to various symptoms of dementia, and how drugs targeting these brain circuits and their neurotransmitters lead to symptomatic improvement, emphasizing memory, psychosis, and agitation. The goal of this chapter is to acquaint the reader with ideas about the clinical and biological aspects of dementia and its current management with various approved drugs as well as novel agents on the horizon.
- Type
- Chapter
- Information
- Stahl's Essential PsychopharmacologyNeuroscientific Basis and Practical Applications, pp. 486 - 537Publisher: Cambridge University PressPrint publication year: 2021
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