The array of tools for addressing the needs of imperiled and conservation-reliant species is increasing. This chapter provides case studies and examples of the use of translocation and captive breeding for addressing threats, and discuss attributes of receiving sites. Tools for tracking species movements and for remote sensing can efficiently provide large amounts of habitat and species data. Sometimes tools can be used to address common threats such as those created by habitat change or pesticide use, benefitting multiple species. We provide Old World vultures offer a case study. Managing for surrogate, umbrella, indicator, focal, keystone, or pollinator species may assist other species as well. Such roles should be acknowledged in prioritizing conservation activities. Emerging technologies, including genetic tools and artificial intelligence, can help to address imperilment and conservation reliance if ethical issues can be navigated.