This chapter shows how competing notions of care shape ethical, political, and amorous life in Shakespearean drama. If care is a virtue, it seems unique among other classically recognized virtues such as courage, justice, and temperance, in that care is more ubiquitous as a feature of normative life and yet less conceptually distinct. While sometimes appearing as a virtue in itself — or as a precondition to the sharpening of any particular virtue — care just as often shows up in Shakespeare’s plays as a demanding expenditure of psychosomatic energies that shades into anxious worry or self-consuming attachments. This chapter in turn illustrates how ancient Greek and Roman virtue ethics inform Shakespeare’s articulations of care as an innate and omnipresent facet of human experience, which can benefit self and others but in its extreme forms also weigh upon body and soul to cause harm. Despite cultivating skepticism concerning our human abilities to know and to exercise the virtues of care, Shakespearean drama also stages encounters with care in its rarest guise: as a benefit that alleviates forms of suffering or distress to which human life is invariably susceptible, and which cultivates our capacities for virtue.