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Chapter 6 - Alzheimer’s Disease

Published online by Cambridge University Press:  21 June 2019

Rob Butler
Affiliation:
Waitemata DHB and North Shore Hospital, Auckland
Cornelius Katona
Affiliation:
Helen Bamber Foundation
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Summary

Alzheimer’s disease (AD) is an irreversible, progressive neuro-degenerative disorder of the brain that affects various aspects of cognitive functions. It manifests as a progressive impairment of day-to-day functioning, eventually leading to a breakdown of even the simplest abilities. It is the commonest cause of dementia in the world. It is a major cause of disability, dependency and carer stress among older people. It places an immense burden on society and is one of the top 10 causes of mortality worldwide [1].

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Publisher: Cambridge University Press
Print publication year: 2019

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References

World Health Organization (2015) The top 10 causes of death. Fact Sheet. World Health Organization. Updated January 2017, www.who.int/mediacentre/factsheets/fs310/en/.Google Scholar
Prince, M., Bryce, R., Albanese, E., et al. (2013) ‘The global prevalence of dementia: A systematic review and metaanalysis’. Alzheimers Dement 9(1): 6375.e2. doi: 10.1016/j.jalz.2012.11.007.Google Scholar
Jorm, A. F., Jolley, D. (1998) ‘The incidence of dementia: A meta-analysis’. Neurology 51: 728–33.Google Scholar
Prince, M., Knapp, M., Guerchet, M., et al. (2014) ‘Dementia UK: Update Second Edition report’. London: King’s College London and the London School of Economics for the Alzheimer’s Society’.Google Scholar
Alzheimer’s Disease International (2016) ‘World Alzheimer Report 2015. The global impact of dementia: An analysis of prevalence, incidence, cost and trends’. London: Alzheimer’s Disease International.Google Scholar
Rae-Grant, A., Blume, W., Lau, C., et al. (1987) ‘The electroencephalogram in Alzheimer-type dementia: A sequential study correlating the electroencephalogram with psychometric and quantitative pathologic data’. Arch Neurol 44(1): 5054.Google Scholar
Jeong, J. (2004) ‘EEG dynamics in patients with Alzheimer’s disease’. Clin Neurophysiol 115(7): 14901505.Google Scholar
Stevens, A., Kircher, T. (1998) ‘Cognitive decline unlike normal aging is associated with alterations of EEG temporo-spatial characteristics’. Eur Arch Psychiatry Clin Neurosci 248(5): 259–66.Google Scholar
Scahill, R. I., Schott, J. M., Stevens, J. M., et al. (2002) ‘Mapping the evolution of regional atrophy in Alzheimer’s disease: Unbiased analysis of fluid-registered serial MRI’. Proc Natl Acad Sci 99: 4703–7.Google Scholar
Lehericy, S., Baulac, M., Chiras, J., et al. (1994) ‘Amygdalohippocampal MR volume measurements in the early stages of Alzheimer disease’. Am J Neuroradiol 15: 929–37.Google Scholar
Chun, W., Johnson, G. V. (2007) ‘The role of tau phosphorylation and cleavage in neuronal cell death’. Front Biosci 12: 733–56.Google Scholar
Killiany, R. J., Hyman, B. T., Gomez-Isla, T., et al. (2002) ‘MRI measures of entorhinal cortex vs hippocampus in preclinical AD’. Neurology 58: 1188–96.CrossRefGoogle ScholarPubMed
Braak, H., Braak, E. (1991) ‘Neuropathological staging of Alzheimer-related changes’. Acta Neuropathol (Berl) 82: 239–59.Google Scholar
Celone, K. A., Calhoun, V. D., Dickerson, B. C., et al. (2006) ‘Alterations in memory networks in mild cognitive impairment and Alzheimer’s disease: An independent component analysis’. J Neurosci 26: 10222–31.CrossRefGoogle ScholarPubMed
World Health Organization (1992) ICD-10 Classifications of Mental and Behavioural Disorder: Clinical Descriptions and Disgnostic Guidelines. Geneva: World Health Organization.Google Scholar
American Psychiatric Association (2013) Diagnostic and Statistical Manual of Mental Disorders (5th ed.). Arlington, VA: American Psychiatric Publishing.Google Scholar
Jack, C. R. Jr., Albert, M. S., Knopman, D. S., et al. (2011) ‘Introduction to revised criteria for the diagnosis of Alzheimer’s disease: National Institute on Aging and the Alzheimer’s Association Workgroups’. Alzheimers Dement 7(3): 257–62.Google Scholar
Waring, S. C., Rosenberg, R. N. (2008) ‘Genome-wide association studies in Alzheimer disease’. Arch Neurol 65(3): 329–34.CrossRefGoogle ScholarPubMed
Turner, P. R., O’Connor, K., Tate, W. P. , Abraham, W. C. (2003) ‘Roles of amyloid precursor protein and its fragments in regulating neural activity, plasticity and memory’. Prog Neurobiol 70(1): 132.CrossRefGoogle ScholarPubMed
Buchhave, P., Minthon, L., Zetterberg, H., et al. (2012) ‘Cerebrospinal fluid levels of β-amyloid 1–42, but not of tau, are fully changed already 5 to 10 years before the onset of Alzheimer dementia’. Arch Gen Psychiatry 69(1): 98106.CrossRefGoogle Scholar
Bouras, C., Hof, P. R., Giannakopoulos, P., et al. (1994) ‘Regional distribution of neurofibrillary tangles and senile plaques in the cerebral cortex of elderly patients: A quantitative evaluation of a one-year autopsy population from a geriatric hospital’. Cereb Cortex 4(2): 138–50.CrossRefGoogle ScholarPubMed
Hooper, N. M. (2005) ‘Roles of proteolysis and lipid rafts in the processing of the amyloid precursor protein and prion protein’. Biochem Soc Trans 33(Pt 2): 335–38.Google Scholar
Hernández, F., Avila, J. (2007) ‘Tauopathies’. Cell Mol Life Sci 64: 2219, https://doi.org/10.1007/s00018–007-7220-x.Google Scholar
Hardy, J., Selkoe, D. J. (2002) ‘The amyloid hypothesis of Alzheimer’s disease: Progress and problems on the road to therapeutics’. Science 297: 353–6.Google Scholar
Nikolaev, A. (2009) ‘APP binds DR6 to cause axon pruning and neuron death via distinct caspases’. Nature 457(7232): 981–89. doi:10.1038/nature07767.Google Scholar
Iqbal, K., Alonso Adel, C., Chen, S., et al. (2005) ‘Tau pathology in Alzheimer disease and other tauopathies’. Biochim Biophys Acta 1739(2–3): 198210.Google Scholar
Gannon, M., Che, P., Chen, Y., et al. (2015) ‘Noradrenergic dysfunction in Alzheimer’s disease’. Front Neurosci 9: 220. doi:10.3389/fnins.2015.00220.Google Scholar
Butzlaff, M., Ponimaskin, E. (2016) ‘The role of serotonin receptors in Alzheimer’s disease’. Opera Medica et Physiologica 2(1): 7786.Google Scholar
Zanetti, O., Solerte, S. B., Cantoni, F. (2009) ‘Life expectancy in Alzheimer’s disease (AD)’. Arch Gerontol Geriatr 49: 237–43.Google Scholar
Burns, A., Lewis, G., Jacoby, R., Levy, R. (1991) ‘Factors affecting survival in Alzheimer’s disease’. Psychol Med 21(2): 363–70.Google Scholar

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