The chapter revisits the criticisms and challenges presented at the book’s outset. It highlights how the book’s central theses - the Systematicity, Understanding, and Autonomy Theses - help resolve issues related to skepticism, overmedicalization, and objectification in medicine. The chapter argues that a moderate position, supported by these theses, provides better understanding of these challenges and suggests potential solutions. The criticisms of skepticism are countered by increased systematicity in knowledge-seeking. Concerns of overmedicalization are tackled through the Autonomy Thesis, which argues that medicalization is justifiable if a condition is harmful and adequately understood by medicine. Objectification, as examined through the Autonomy Thesis, can impede medicine’s aim by undermining personal understanding. The chapter emphasizes the necessity of counteracting the potential decrease in personal understanding caused by standardization and technological advances.