In the first stages of this research, presented Chapter 5, we consciously decided to not undertake least-cost-path analyses because we were interested in exploratory and experimental applications of network science approaches, and we were aware of several issues raised in the application of least-cost-path analysis. Therefore the trade-off between costs and benefits of such an application did not seem remunerative enough or worthwhile in the first instance. However, it was also clear from the analyses that the variable of distance was relevant for the analyses and that an integration of network science approaches within GIS applications, now more and more common, is promising and profitable.1 Therefore, this chapter present a multi-scale analysis of transportation routes in Etruria and Latium vetus based on least-cost path analyses, although we are aware of the critique and problems of such applications.2