The majority of works written in Early Modern Morocco in the natural sciences remain in manuscript, which has made them difficult to access and evaluate. The chapter takes up astronomical, medical, and alchemical works to discuss the types of approaches scholars in Morocco used and the nature of the questions in which they were interested. Drawing on recent work in the field, it demonstrates that the occult sciences, including lettrism, were part and parcel of this project and that Moroccan scholars produced innovative syntheses and commentaries throughout the period in consideration.