Skip to main content Accessibility help
×
Hostname: page-component-78c5997874-4rdpn Total loading time: 0 Render date: 2024-11-05T13:10:31.588Z Has data issue: false hasContentIssue false

19 - Contraceptive vaccine development

Published online by Cambridge University Press:  21 January 2010

Karen E. Mate
Affiliation:
Cooperative Research Centre for Conservation and Management of Marsupials, Department of Biological Sciences, Macquarie University, NSW 2109, Australia
Lyn A. Hinds
Affiliation:
Pest Animal Control Cooperative Research Centre, CSIRO Sustainable Ecosystems, GPO Box 284, Canberra, ACT 2601, Australia
William V. Holt
Affiliation:
Zoological Society of London
Amanda R. Pickard
Affiliation:
Zoological Society of London
John C. Rodger
Affiliation:
Marsupial CRC, New South Wales
David E. Wildt
Affiliation:
Smithsonian National Zoological Park, Washington DC
Get access

Summary

INTRODUCTION AND OBJECTIVES

Public acceptability of conventional strategies for the management of over-abundant wild animal populations (e.g. shooting, trapping, poisoning) is continuing to decline, particularly as they are not sustainable in the long term, especially for large, free-ranging populations. Significant interest is being shown in an ecologically-based approach to management of pest populations which recognises that a thorough understanding of the biology and ecology of the species is essential before integrated management of the species can be implemented (Singleton et al., 1999).

This chapter, which should be read in conjunction with Rodger's commentary (Rodger, Chapter 18) focuses on the development of contraceptive vaccines that are highly effective, long-lasting and that can be delivered to large, free-ranging populations in an environmentally safe and publicly acceptable manner. Progress will be reviewed for (1) the identification of appropriate contraceptive targets, (2) the strategies employed to increase the magnitude and longevity of the immune response to specifically target the reproductive tract and ensure species specificity and (3) the delivery of the vaccine via both disseminating and non-disseminating systems. We also address some of the issues relating to public acceptance of some of the proposed methods for delivery of fertility control and future priorities for research.

STATE OF THE ART

Contraceptive targets

A long-term contraceptive effect has been achieved in several animal species following immunisation with reproductive hormones (Cowan et al., Chapter 20).

Type
Chapter
Information
Publisher: Cambridge University Press
Print publication year: 2002

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Barber, M. R. & Fayrer-Hosken, R. A. (2000). Possible mechanisms of mammalian immunocontraception. Journal of Reproductive Immunology 46, 103–124CrossRefGoogle ScholarPubMed
Bomford, M. (1990). A Role for Fertility Control in Wildlife Management? Bulletin No. 7, Canberra, Bureau of Rural Resources
Bradley, M. P., Hinds, L. A. & Bird, P. H. (1997). A bait-delivered immunocontraceptive vaccine for the European red fox (Vulpes vulpes) by the year 2002?Reproduction, Fertility and Development 9, 111–116CrossRefGoogle ScholarPubMed
Brochier, B., Kieny, M. P., Costy, F., Coppens, P., Bauduin, B., Lecocq, J. P., Languet, B., Chappuis, G., Desmettre, P., Afiademanyo, K., Libois, R. & Pastoret, P.-P. (1991). Large scale eradication of rabies using recombinant vaccinia-rabies vaccine. Nature 354, 520–522CrossRefGoogle ScholarPubMed
Bronson, R. G., Cooper, G. & Rosenfield, D. (1984). Sperm antibodies: their role in infertility. Fertility and Sterility 42, 171–182Google ScholarPubMed
Chambers, L., Lawson, M. & Hinds, L. A. (1999). Biological control of rodents – the case for fertility control using immunocontraception. In Ecologically-based Rodent Management (Eds. G. R. Singleton, L. A. Hinds, H. Leirs & Z. Zhang), pp. 215–242. ACIAR, Canberra
Chambers, L. K., Singleton, G. R. & Hood, G. M. (1997). Immunocontraception as a potential control method of wild rodent populations. Belgian Journal of Zoology 127, 145–156Google Scholar
Davis, S. S. (1996). Vaccine delivery systems: particulate delivery systems. Vaccine 14, 672–680Google Scholar
Duckworth, J. A., Buddle, B. M. & Scobie, S. (1998). Fertility of brushtail possums (Trichosurus vulpecula) immunised against spermJournal of Reproductive Immunology 37, 125–138CrossRefGoogle ScholarPubMed
Epifano, O. & Dean, J. (1994). Biology and structure of the zona pellucida: a target for immunocontraception. Reproduction, Fertility and Development 6, 319–330CrossRefGoogle ScholarPubMed
Fayrer-Hosken, R. A., Bertschinger, H. J., Kirkpatrick, J. F., Grobler, D., Lamberski, N., Honneyman, G. & Ulrich, T. (1999). Contraceptive potential of the porcine zona pellucida vaccine in the African elephant (Loxodonta africana). Theriogenology 52, 835–846CrossRefGoogle Scholar
Fitzgerald, G., Wilkinson, R. & Saunders, L. (2000). Public perceptions and issues in possum control. In The Brushtail Possum: Biology, Impact and Management of an Introduced Marsupial (Ed. T. L. Montague), pp. 187–197. Manaaki Whenua Press, Lincoln, New Zealand
Frayne, J. & Hall, L. (1999). The potential use of sperm antigens as targets for immunocontraception; past, present and future. Journal of Reproductive Immunology 43, 1–33CrossRefGoogle ScholarPubMed
Hood, E. E. & Jilka, J. M. (1999). Plant-based production of xenogenic proteins. Current Opinion in Biotechnology 10, 382–386CrossRefGoogle ScholarPubMed
Jackson, R. J., Maguire, D. J., Hinds, L. A. & Ramshaw, I. A. (1998). Infertility in mice induced by a recombinant ectromelia virus expressing mouse zona pellucida glycoprotein 3. Biology of Reproduction 58, 152–159CrossRefGoogle ScholarPubMed
Kirkpatrick, J. F., Liu, I. K. M., Turner, J. W., Naugle, R. & Keiper, R. R. (1992). Long-term effects of porcine zonae pellucidae immunocontraception on ovarian function of feral horses. Journal of Reproduction and Fertility 94, 437–444CrossRefGoogle ScholarPubMed
Kirkpatrick, J. F., Turner, J. W., Liu, I. K. M. & Fayrer-Hosken, R. (1996). Applications of pig zona pellucida immunocontraception to wildlife fertility. Journal of Reproduction and Fertility, Suppl. 50, 183–189Google ScholarPubMed
Koide, Y., Nagata, T., Yoshida, A. & Uchijima, M. (2000). DNA vaccines. Japanese Journal of Pharmacology 83, 167–174CrossRefGoogle ScholarPubMed
Liljeqvist, S. & Stahl, S. (1999). Production of recombinant subunit vaccines: protein immunogens, live delivery systems and nucleic acid vaccines. Journal of Biotechnology 73, 1–33CrossRefGoogle ScholarPubMed
Lou, Y.-H., Bagavant, H., Ang, J., McElveen, M. F., Thai, H. & Tung, K. S. K. (1996). Influence of autoimmune disease on ZP3 contraceptive design. Journal of Reproduction and Fertility, Suppl. 50, 159–163Google Scholar
Lubitz, W., Witte, A., Eko, F. O., Kamal, M., Jechlinger, W., Brand, E., Marchart, J., Haidinger, W., Huter, V., Felnerova, D., Stralis-Alves, N., Lechleitner, S., Melzer, H., Szostak, M. P., Resch, S., Mader, H., Kuen, B., Mayr, B., Mayrhofer, P., Geretschlager, R., Haslberger, A. & Hensel, A. (1999) Extended bacterial ghost system. Journal of Biotechnology 73, 261–273CrossRefGoogle ScholarPubMed
Mason, H. S., Ball, J. M., Shi, J.-J., Jiang, X., Estes, M. K. & Arntzen, C. J. (1996). Expression of Norwalk virus capsid protein in transgenic tobacco and potato and its oral immunogenicity in mice. Proceedings of the National Academy of Sciences USA 93, 5335–5340CrossRefGoogle ScholarPubMed
Mason, H. S., Lam, D. M. & Arntzen, C. J. (1992). Expression of hepatitis B surface antigen in transgenic plants. Proceedings of the National Academy of Sciences USA 89, 11745–11749CrossRefGoogle ScholarPubMed
Mate, K. E., Harris, M. S. & Rodger, J. C. (2000). Fertilisation in Monotreme, Marsupial and Eutherian Mammals. In Fertilisation in Protozoa and Metazoan Animals (Eds. J. J. Tarin & A. Cano), pp. 223–275. Springer-Verlag, BerlinCrossRef
McLaren, A. (1966). Studies on the isoimmunisation of mice with spermatozoa. Fertility and Sterility 17, 492–497CrossRefGoogle Scholar
Nie, G. Y., Butt, A. R., Salamonsen, L. A. & Findlay, J. K. (1997). Hormonal and non-hormonal agents at implantation as targets for contraception. Reproduction, Fertility and Development 9, 65–76CrossRefGoogle Scholar
Oogjes, G. (1997). Ethical aspects and dilemmas of fertility control of unwanted wildlife: an animal welfarist's perspective. Reproduction, Fertility and Development 9, 163–168CrossRefGoogle ScholarPubMed
Prasad, S. V., Wilkins, B. & Dunbar, B. S. (1996). Molecular biology approaches to evaluate species variation in immunogenicity and antigenicity of zona pellucida proteins. Journal of Reproduction and Fertility, Suppl. 50, 143–149Google ScholarPubMed
Rhim, S. H., Millar, S. E., Robey, F., Luo, A. M., Lou, Y. H., Yule, T., Allen, P., Dean, J. & Tung, K. S. K. (1992). Autoimmune disease of the ovary induced by a ZP3 peptide from the mouse zona pellucida. Journal of Clinical Investigation 89, 28–35CrossRefGoogle ScholarPubMed
Shellam, G. R. (1994). The potential of murine cytomegalovirus as a viral vector for immunocontraception. Reproduction, Fertility and Development 6, 401–409CrossRefGoogle ScholarPubMed
Singleton, G. R., Leirs, H., Hinds, L. A. & Zhang, Z. (1999). Ecologically-based management of rodents – re-evaluating our approach to an old problem. In Ecologically-based Rodent Management (Eds. G. R. Singleton, L. A. Hinds, H. Leirs & Z. Zhang), pp. 17–29. ACIAR, Canberra
Smith, G., Walmsley, A. & Polkinghorne, I. (1997). Plant-derived immunocontraceptive vaccines. Reproduction, Fertility and Development 9, 85–89CrossRefGoogle ScholarPubMed
Szostak, M. P., Hensel, A., Eko, F. O., Klein, R., Auer, T., Mader, H., Haslberger, A., Bunka, S., Wanner, G. & Lubitz, W. (1996). Bacterial ghosts: non-living candidate vaccines. Journal of Biotechnology 44, 161–170CrossRefGoogle ScholarPubMed
Tyndale-Biscoe, C. H. (1994). Virus-vectored immunocontraception of feral animals. Reproduction, Fertility and Development 6, 9–16CrossRefGoogle Scholar
Williams, C. K. (1997). Development and use of virus-vectored immunocontraception. Reproduction, Fertility and Development 9, 169–178CrossRefGoogle ScholarPubMed
Xuan, X., Tuchiya, K., Sato, I., Nishikawa, Y., Onoderaz, Y., Takashima, Y., Yamamoto, A., Katsumata, A., Iwata, A., Ueda, S., Mikama, T. & Otsuka, H. (1998). Biological and immunogenic properties of rabies virus glycoprotein expressed by canine herpes virus vector. Vaccine 16, 969–976CrossRefGoogle Scholar
Yann Campbell Hoare Wheeler (1999). Research report into public attitudes towards biotechnology. Biotechnology Australia Report viewed at http://www.isr.gov.au/ba/index.html

Save book to Kindle

To save this book to your Kindle, first ensure [email protected] is added to your Approved Personal Document E-mail List under your Personal Document Settings on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part of your Kindle email address below. Find out more about saving to your Kindle.

Note you can select to save to either the @free.kindle.com or @kindle.com variations. ‘@free.kindle.com’ emails are free but can only be saved to your device when it is connected to wi-fi. ‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.

Find out more about the Kindle Personal Document Service.

  • Contraceptive vaccine development
    • By Karen E. Mate, Cooperative Research Centre for Conservation and Management of Marsupials, Department of Biological Sciences, Macquarie University, NSW 2109, Australia, Lyn A. Hinds, Pest Animal Control Cooperative Research Centre, CSIRO Sustainable Ecosystems, GPO Box 284, Canberra, ACT 2601, Australia
  • Edited by William V. Holt, Zoological Society of London, Amanda R. Pickard, Zoological Society of London, John C. Rodger, David E. Wildt, Smithsonian National Zoological Park, Washington DC
  • Book: Reproductive Science and Integrated Conservation
  • Online publication: 21 January 2010
  • Chapter DOI: https://doi.org/10.1017/CBO9780511615016.023
Available formats
×

Save book to Dropbox

To save content items to your account, please confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account. Find out more about saving content to Dropbox.

  • Contraceptive vaccine development
    • By Karen E. Mate, Cooperative Research Centre for Conservation and Management of Marsupials, Department of Biological Sciences, Macquarie University, NSW 2109, Australia, Lyn A. Hinds, Pest Animal Control Cooperative Research Centre, CSIRO Sustainable Ecosystems, GPO Box 284, Canberra, ACT 2601, Australia
  • Edited by William V. Holt, Zoological Society of London, Amanda R. Pickard, Zoological Society of London, John C. Rodger, David E. Wildt, Smithsonian National Zoological Park, Washington DC
  • Book: Reproductive Science and Integrated Conservation
  • Online publication: 21 January 2010
  • Chapter DOI: https://doi.org/10.1017/CBO9780511615016.023
Available formats
×

Save book to Google Drive

To save content items to your account, please confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account. Find out more about saving content to Google Drive.

  • Contraceptive vaccine development
    • By Karen E. Mate, Cooperative Research Centre for Conservation and Management of Marsupials, Department of Biological Sciences, Macquarie University, NSW 2109, Australia, Lyn A. Hinds, Pest Animal Control Cooperative Research Centre, CSIRO Sustainable Ecosystems, GPO Box 284, Canberra, ACT 2601, Australia
  • Edited by William V. Holt, Zoological Society of London, Amanda R. Pickard, Zoological Society of London, John C. Rodger, David E. Wildt, Smithsonian National Zoological Park, Washington DC
  • Book: Reproductive Science and Integrated Conservation
  • Online publication: 21 January 2010
  • Chapter DOI: https://doi.org/10.1017/CBO9780511615016.023
Available formats
×