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19 - Contraceptive vaccine development

Published online by Cambridge University Press:  21 January 2010

Karen E. Mate
Affiliation:
Cooperative Research Centre for Conservation and Management of Marsupials, Department of Biological Sciences, Macquarie University, NSW 2109, Australia
Lyn A. Hinds
Affiliation:
Pest Animal Control Cooperative Research Centre, CSIRO Sustainable Ecosystems, GPO Box 284, Canberra, ACT 2601, Australia
William V. Holt
Affiliation:
Zoological Society of London
Amanda R. Pickard
Affiliation:
Zoological Society of London
John C. Rodger
Affiliation:
Marsupial CRC, New South Wales
David E. Wildt
Affiliation:
Smithsonian National Zoological Park, Washington DC
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Summary

INTRODUCTION AND OBJECTIVES

Public acceptability of conventional strategies for the management of over-abundant wild animal populations (e.g. shooting, trapping, poisoning) is continuing to decline, particularly as they are not sustainable in the long term, especially for large, free-ranging populations. Significant interest is being shown in an ecologically-based approach to management of pest populations which recognises that a thorough understanding of the biology and ecology of the species is essential before integrated management of the species can be implemented (Singleton et al., 1999).

This chapter, which should be read in conjunction with Rodger's commentary (Rodger, Chapter 18) focuses on the development of contraceptive vaccines that are highly effective, long-lasting and that can be delivered to large, free-ranging populations in an environmentally safe and publicly acceptable manner. Progress will be reviewed for (1) the identification of appropriate contraceptive targets, (2) the strategies employed to increase the magnitude and longevity of the immune response to specifically target the reproductive tract and ensure species specificity and (3) the delivery of the vaccine via both disseminating and non-disseminating systems. We also address some of the issues relating to public acceptance of some of the proposed methods for delivery of fertility control and future priorities for research.

STATE OF THE ART

Contraceptive targets

A long-term contraceptive effect has been achieved in several animal species following immunisation with reproductive hormones (Cowan et al., Chapter 20).

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Chapter
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Publisher: Cambridge University Press
Print publication year: 2002

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References

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  • Contraceptive vaccine development
    • By Karen E. Mate, Cooperative Research Centre for Conservation and Management of Marsupials, Department of Biological Sciences, Macquarie University, NSW 2109, Australia, Lyn A. Hinds, Pest Animal Control Cooperative Research Centre, CSIRO Sustainable Ecosystems, GPO Box 284, Canberra, ACT 2601, Australia
  • Edited by William V. Holt, Zoological Society of London, Amanda R. Pickard, Zoological Society of London, John C. Rodger, David E. Wildt, Smithsonian National Zoological Park, Washington DC
  • Book: Reproductive Science and Integrated Conservation
  • Online publication: 21 January 2010
  • Chapter DOI: https://doi.org/10.1017/CBO9780511615016.023
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  • Contraceptive vaccine development
    • By Karen E. Mate, Cooperative Research Centre for Conservation and Management of Marsupials, Department of Biological Sciences, Macquarie University, NSW 2109, Australia, Lyn A. Hinds, Pest Animal Control Cooperative Research Centre, CSIRO Sustainable Ecosystems, GPO Box 284, Canberra, ACT 2601, Australia
  • Edited by William V. Holt, Zoological Society of London, Amanda R. Pickard, Zoological Society of London, John C. Rodger, David E. Wildt, Smithsonian National Zoological Park, Washington DC
  • Book: Reproductive Science and Integrated Conservation
  • Online publication: 21 January 2010
  • Chapter DOI: https://doi.org/10.1017/CBO9780511615016.023
Available formats
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Save book to Google Drive

To save content items to your account, please confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account. Find out more about saving content to Google Drive.

  • Contraceptive vaccine development
    • By Karen E. Mate, Cooperative Research Centre for Conservation and Management of Marsupials, Department of Biological Sciences, Macquarie University, NSW 2109, Australia, Lyn A. Hinds, Pest Animal Control Cooperative Research Centre, CSIRO Sustainable Ecosystems, GPO Box 284, Canberra, ACT 2601, Australia
  • Edited by William V. Holt, Zoological Society of London, Amanda R. Pickard, Zoological Society of London, John C. Rodger, David E. Wildt, Smithsonian National Zoological Park, Washington DC
  • Book: Reproductive Science and Integrated Conservation
  • Online publication: 21 January 2010
  • Chapter DOI: https://doi.org/10.1017/CBO9780511615016.023
Available formats
×