In act 4 of The Comedy of Errors, Adriana, in response to her husband's wildly erratic behaviour, recruits one Doctor Pinch to cure his apparent madness. Antipholus of Ephesus is of course not really mad at all, but understandably frustrated and confused with the events of the day, which have seen him locked out of his own house and accused of failing to pay for valuables that he actually never received, thanks to a series of misunderstandings involving his identical twin, Antipholus of Syracuse. When Antipholus of Ephesus refuses to cooperate with his wife's well-intentioned intervention, Doctor Pinch attempts an exorcism to drive away the demons which he supposes to possess him:

Of course, Pinch's attempted exorcism fails, because there is no Satan to exorcise, and Antipholus becomes so angry that Adriana has him forcibly bound and taken away in Pinch's custody. In a later scene a messenger reports that Antipholus and his servant Dromio have gnawed through their bonds and escaped and then captured and tormented the hapless Doctor Pinch, burning off his beard “with brands of fire,” putting it out again with “Great pails of puddled mire,” and then preaching patience to him while cutting him with scissors and concludes that “unless you send some present help, / Between them they will kill the conjurer” (5.1.172, 74–76, 177–78).