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41 - REM sleep and dreams: relationship to anxiety, psychosomatic, and behavioral disorders

from Section VI - Disturbance in the REM sleep-generating mechanism

Published online by Cambridge University Press:  07 September 2011

By
Luigi Ferini-Strambi
Edited by
Birendra N. Mallick ,
S. R. Pandi-Perumal ,
Robert W. McCarley  and
Adrian R. Morrison
Luigi Ferini-Strambi
Affiliation:
Università Vita-Salute San Raffaele, Italy
Birendra N. Mallick
Affiliation:
Jawaharlal Nehru University
S. R. Pandi-Perumal
Affiliation:
Somnogen Canada Inc, Toronto
Robert W. McCarley
Affiliation:
Harvard University, Massachusetts
Adrian R. Morrison
Affiliation:
University of Pennsylvania
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Summary

Summary

Sleep disturbances are frequently associated with, and can comprise core features of, anxiety disorders. Studies using objective sleep recordings have demonstrated impaired sleep initiation and maintenance in persons with generalized anxiety disorder or panic disorder, but a normal latency to REM sleep. Increased phasic motor activity and eye movement density during REM sleep have been reported in combat veterans with post-traumatic stress disorder: moreover, nightmares and other symptomatic awakenings disproportionately arise from REM sleep.

One of the most consistent behavioral manifestations of sleep loss is the worsening of mood state. With prolonged sleep deprivation it is possible to observe an increase in self-reported feelings of depressed mood, anger, frustration, and anxiety. Interestingly, there is little evidence that waking stress leads to increased REM, although there have been reports of small elevations in REM following severe emotional upset. REM sleep might have some sort of calming effect.

The relationship between somatic distress and dream disturbance has been recently investigated: individuals who reported more incidents of both bad dreams and nightmares did report higher levels of somatic distress. However, REM sleep behavior disorder (RBD), a parasomnia characterized by complex and often violent motor behaviors that emerge from REM sleep and that are associated with violent and unpleasant dreams, represents a particular condition. A discrepancy between the aggressiveness displayed in dreams and the placid and mild-mannered temperament has been observed in patients with RBD.

Type
Chapter
Information
Rapid Eye Movement Sleep
Regulation and Function
 , pp. 417 - 426
Publisher: Cambridge University Press
Print publication year: 2011

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References

American Psychiatric Association (2000) Diagnostic and Statistical Manual of Mental Disorders, 4th Ed (text revision, DSM-IV-R). Washington, DC:American Psychiatric Association Press.Google Scholar
American Sleep Disorders Association (2005) ICSD-II, International Classification of Sleep Disorders: Diagnostic and Coding Manual. Chicago, IL:American Academy of Sleep Medicine.Google Scholar
Barrett, D. (1996) Trauma and Dreams. Cambridge, MA:Harvard University Press.Google Scholar
Beyer, J. L. & Krishnan, K. R. (2002) Volumetric brain imaging findings in mood disorders. Bipolar Disord 4: –104.CrossRefGoogle ScholarPubMed
Blagrove, M., Farmer, L. & Williams, E. (2004) The relationship of nightmare frequency and nightmare distress to well-being. J Sleep Res 13: –36.CrossRefGoogle ScholarPubMed
Boeve, B. F., Silber, M. H., Saper, C. B. . (2007) Pathophysiology of REM sleep behavior disorder and relevance to neurodegenerative disease. Brain 130: –88.CrossRefGoogle ScholarPubMed
Breslau, N., Roth, T. & Rosenthal, L. . (1996) Sleep disturbance and psychiatric disorders: a longitudinal epidemiological study of young adults. Biol Psychiatry 39: –18.CrossRefGoogle ScholarPubMed
Breslau, N., Roth, T., Burduvali, E. . (2004) Sleep in lifetime posttraumatic stress disorder: a community-based polysomnographic study. Arch Gen Psychiatry 61: –16.CrossRefGoogle ScholarPubMed
Caldwell, J., Caldwell, J., Brown. D, L, . (2004) The effects of 37 h of continuous wakefulness on the physiological arousal, cognitive performance, self-reported mood, and simulator flight performance of F-117A pilots. Military Psychology 16: –81.CrossRefGoogle Scholar
Cartwright, R. D., Monroe, L. & Palmer, C. (1967) Individual differences in response to REM sleep deprivation. Arch Gen Psychiatr 16: –303.CrossRefGoogle Scholar
Choi, J, Kang, D., Kim, J. . (2005) Decreased caudal anterior cingulate gyrus volume and positive symptoms in schizophrenia. Psychiat Res: Neuroim 139: –47.CrossRefGoogle Scholar
Dinges, D. F., Pack, F., Williams, K. . (1997) Cumulative sleepiness, mood disturbance, and psychomotor vigilance performance decrements during a week of sleep restricted to 4–5 h per night. Sleep 20: –77.Google ScholarPubMed
Domhoff, G. W. (2001) A new neurocognitive theory of dreams. Dreaming 11: –33.CrossRefGoogle Scholar
Fantini, M. L., Ferini-Strambi, L. & Montplaisir, J. (2005a) Idiopathic REM sleep behavior disorder: toward a better nosological definition. Neurology 64: –6.CrossRefGoogle Scholar
Fantini, M. L., Corona, A., Clerici, S. . (2005b) Aggressive dream content without daytime aggressiveness in REM sleep behaviour disorder. Neurology 65: –CrossRefGoogle Scholar
Fantini, M. L., Postuma, R. B., Montplaisir, J. . (2006) Olfactory deficit in idiopathic REM sleep behavior disorder. Brain Res Bull 70: –90.CrossRefGoogle Scholar
Fantini, M. L. & Ferini-Strambi, L. (2007) REM-related dreams. In REM Sleep Behavior Disorder: the New Science of Dreaming, eds. McNamara, P. & Barrett, D.. Westport, CT: Greenwood Publishers, pp. 185–200.Google Scholar
Ferini-Strambi, L., Di Gioia, M. S., Castronovo, V. . (2004) Neuropsychological assessment in idiopathic REM sleep behavior disorder (RBD). Does the idiopathic form of RBD really exist?Neurology 62: –5.CrossRefGoogle ScholarPubMed
Ferini-Strambi, L., Fantini, M. L., Zucconi, M. . (2005) REM sleep behavior disorder. Neurol 26 (Suppl 3): –92.Google Scholar
Foulkes, D. (1967) Dreams of the male child: four case studies. J Child Psychol Psychiatry 8: –98.CrossRefGoogle ScholarPubMed
Gagnon, J. F., Bédard, M. A., Fantini, M. L. . (2002) REM sleep behavior disorder and REM sleep without atonia in Parkinson’s disease. Neurology 59: –9.CrossRefGoogle ScholarPubMed
Gillin, J. C., Buchsbaum, M., Wu, J. . (2001) Sleep deprivation as a model experimental antidepressant treatment: findings from functional brain imaging. Depress Anxiety 2: –49.Google Scholar
Habukawa, M., Uchimura, N., Maeda, M. . (2007) Sleep findings in young adult patients with posttraumatic stress disorder. Biol Psychiatry 62: –82.CrossRefGoogle ScholarPubMed
Hobson, J. A. & McCarley, R. W. (1977) The brain as a dream state generator: an activation-synthesis hypothesis of the dream process. Am J Psychiatry 134:–48.Google ScholarPubMed
Hohagan, F., Lis, S., Krieger, S. . (1994) Sleep EEG of patients with obsessive-compulsive disorder. Eur Arch Psychiatry Clin Neurosci 243: –8.Google Scholar
Insel, T., Gillin, J., Moore, A. . (1982) The sleep of patients with obsessive-compulsive disorder. Arch Gen Psychiatry 39: –7.CrossRefGoogle ScholarPubMed
Iranzo, A., Graus, F., Clover, L. . (2006) Rapid eye movement sleep behavior disorder and potassium channel antibody-associated limbic encephalitis. Ann Neurol 59: –81.CrossRefGoogle ScholarPubMed
Jung, C. (1974) Dreams. Princeton, NJ: Princeton University Press.Google Scholar
Kahn-Greene, E. T., Killgore, D. B. & Kamimori, G. (2007) The effects of sleep deprivation on symptoms of psychopathology in healthy adults. Sleep Med 8: –21.CrossRefGoogle ScholarPubMed
Kupfer, D. J. & Bowers, M. B. (1972) REM sleep and central monoamine oxidase inhibition. Psychopharmacology 27: –90.CrossRefGoogle ScholarPubMed
Landolt, H. P., de Boer, L. P., Raimo, E. B. . (1999) Almost complete absence of REM sleep in a depressed patient during six months on Phenelzine. Sleep Res Online 2 (Suppl) 1: .Google Scholar
Levin, R. & Fireman, G. (2002) Nightmares prevalence, nightmares distress, and self-reported psychological disturbance. Sleep 25: –12.Google ScholarPubMed
Levin, R., Lantz, E., Fireman, G. . (2009) The relationship between disturbed dreaming and somatic distress. J Nerv Ment Dis 197: –12.CrossRefGoogle ScholarPubMed
Liguori, R., Vincent, A., Clover, L. . (2001) Morvan’s syndrome: peripheral and central nervous system and cardiac involvement with antibodies to voltage-gated potassium channels. Brain 124: –26.CrossRefGoogle ScholarPubMed
Maquet, P., Peters, J. M., Aerts, J. . (1996) Functional neuroanatomy of human repid eye movement sleep and dreaming. Nature 383: –6.CrossRefGoogle Scholar
McKeith, I. G. for the DLB Consortium (2005) Diagnosis and management of dementia with Lewy bodies: third report of the DLB Consortium. Neurology 65: –72.CrossRefGoogle ScholarPubMed
Mellman, T. (2008) Sleep and anxiety disorders. Sleep Med Clin 3: –8.CrossRefGoogle Scholar
Mellman, T. & Uhde, T. (1989) Electroencephalographic sleep in panic disorder: a focus on sleep-related panic attacks. Arch Gen Psychiatry 46: –84.CrossRefGoogle ScholarPubMed
Meyer-Lindenberg, A. S., Olsen, R. K., Kohn, P. D. . (2005) Regionally specific disturbance of dorsolateral prefrontal-hippocampal functional connectivity in schizophrenia. Arch Gen Psychiatry 62: –86.CrossRefGoogle Scholar
Morris, J. S., Ohman, A. & Dolan, R. (1998) Conscious and unconscious emotional learning in the human amygdala. Nature 393: –70.CrossRefGoogle ScholarPubMed
Nielsen, T. & Levin, R. (2007) Nightmares: a new neurocognitive model. Sleep Med Rev 11: –310.CrossRefGoogle ScholarPubMed
Nofzinger, E. A., Mintun, M., Wiseman, M. B. . (1997) Forebrain activation in REM sleep: an FDG PET study. Brain Res 770: –201.Google Scholar
Nolen-Hoeksema, S. (1990) Sex Differences in Depression. Stanford, CA:Stanford University Press.Google Scholar
Noyes, R. Jr, Watson, D. B., Letuchy, E. M. . (2005) Relationship between hypochondriacal concerns and personality dimensions and traits in a military population. J Nerv Ment Dis 193: –18.CrossRefGoogle Scholar
Ohayon, M., Morselli, P. L. & Guilleminault, C. (1997) Prevalence of nightmares and their relationship to psychopathology and daytime functioning in insomnia subjects. Sleep 20: –8.CrossRefGoogle ScholarPubMed
Pesant, N. & Zadra, A. (2006) Dream content and psychological well-being: a longitudinal study of the continuity hypothesis. J Clin Psychol 62:–21.CrossRefGoogle ScholarPubMed
Postuma, R. B., Lang, A., Massicotte-Marquez, J. . (2006) Potential early markers of Parkinson disease in idiopathic REM sleep behavior disorder. Neurology 66: –51.CrossRefGoogle ScholarPubMed
Postuma, R. B., Gagnon, J. F., Vendette, M. . (2009) Quantifying the risk of neurodegenerative disease in idiopathic REM sleep behavior disorder. Neurology 72: –300.CrossRefGoogle ScholarPubMed
Rief, W., Hiller, W. & Margraf, J. (1998) Cognitive aspects of hypochondriasis and the somatization syndrome. J Abnorm Psychol 107: –95.CrossRefGoogle ScholarPubMed
Robinson, D., Walsleben, J., Pollack, S. . (1998) Nocturnal polysomnography in obsessive-compulsive disorder. Psychiatry Res 80: –63.CrossRefGoogle ScholarPubMed
Saletu-Zyhlarz, G., Saletu, B., Anderer, P. . (1997) Nonorganic insomnia in generalized anxiety disorder: controlled studies on sleep, awakening and daytime vigilance utilizing polysomnography and EEG mapping. Neuropsychobiology 36: –29.CrossRefGoogle ScholarPubMed
Scott, J. P., McNaughton, L. & Polman, R. C. (2006) Effects of sleep deprivation and exercise on cognitive, motor performance and mood. Physiol Behav 87: –408.CrossRefGoogle Scholar
Schenck, C. H. & Mahowald, M. W. (2002) REM sleep behavior disorder: clinical, developmental, and neuroscience perspectives 16 years after its formal identification in Sleep. Sleep 25:–38.CrossRefGoogle ScholarPubMed
Schenck, C. H., Bundlie, S. R. & Mahowald, M. W. (2003) REM behavior disorder (RBD): delayed emergence of parkinsonism and/or dementia in 65% of older men initially diagnosed with idiopathic RBD, and analysis of the minimum and maximum tonic and/or phasic electromyographic abnormalities found during REM sleep. Sleep 26: Abstract Supplement: .Google Scholar
Simard, V., Nielsen, T., Tremblay, R. E. . (2008) Longitudinal study of bad dreams in preschool children: prevalence, demographic correlates, risk and protective factors. Sleep 31: –70.CrossRefGoogle ScholarPubMed
Smith, C. & Lapp, L. (1991) Increases in number of REMS and REM density in humans following an intensive learning period. Sleep 14: –30.CrossRefGoogle ScholarPubMed
Staner, L., Kerkhofs, M., Detroux, D. . (1995) Acute, subchronic and withdrawal sleep EEG changes during treatment with paroxetine and amitryptyline: a double blind randomised trial in major depression. Sleep 18: –7.Google Scholar
Stirling, J., Hellewell, J., Blakey, A. . (2006) Thought disorder in schizophrenia is associated with both executive dysfunction and circumscribed impairments in semantic function. Psychol Med 20: –10.Google Scholar
Thomas, M., Sing, H., Belenky, G. . (2000) Neural basis of alertness and cognitive performance impairments during sleepiness. I. Effects of 24 h of sleep deprivation on waking human regional activity. J Sleep Res 9: –52.CrossRefGoogle Scholar
Videbech, P. (2000) PET measurements of brain glucose metabolism and blood flow in major depressive disorder: a critical review. Acta Psychiatr Scand 101: –20.CrossRefGoogle ScholarPubMed
Watt, M. C. & Stewart, S. H. (2000) Anxiety sensitivity mediates the relationships between childhood learning experiences and elevated hypochondriacal concerns in young adulthood. J Psychosom Res 49: –18.CrossRefGoogle ScholarPubMed
Wyatt, R. J., Fram, D. H., Kupferm, D. J. . (1971a) Total, prolonged drug induced REM sleep suppresssion in anxious depressed patients. Arch Gen Psychiat 24: –55.CrossRefGoogle Scholar
Wyatt, R. J., Fram, D. H. & Buchbinder, R. (1971b) Treatment of intractable narcolepsy with a monoamine oxidase inhibitor. New Eng J Med 285: –91.CrossRefGoogle ScholarPubMed
Zadra, A. & Donden, D. C. (1993) Variety and intensity of emotions in bad dreams and nightmares. Can Psychol 34: .Google Scholar
Zohar, D., Tzischinsky, O., Epstein, R. . (2005) The effects of sleep loss on medical residents’ emotional reactions to work events: a cognitive-energy model. Sleep 28: –54.CrossRefGoogle ScholarPubMed

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