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25 - Neuropeptides and REM sleep

from Section IV - Neuroanatomy and neurochemistry

Published online by Cambridge University Press:  07 September 2011

By
Oscar Prospéro-García ,
Mónica Méndez-Díaz ,
Alejandra E. Ruiz-Contreras  and
Marcel Pérez-Morales
Edited by
Birendra N. Mallick ,
S. R. Pandi-Perumal ,
Robert W. McCarley  and
Adrian R. Morrison
Oscar Prospéro-García
Affiliation:
Universidad Nacional Autónoma de México
Mónica Méndez-Díaz
Affiliation:
Universidad Nacional Autónoma de México
Alejandra E. Ruiz-Contreras
Affiliation:
Universidad Nacional Autónoma de México
Marcel Pérez-Morales
Affiliation:
Universidad Nacional Autónoma de México
Birendra N. Mallick
Affiliation:
Jawaharlal Nehru University
S. R. Pandi-Perumal
Affiliation:
Somnogen Canada Inc, Toronto
Robert W. McCarley
Affiliation:
Harvard University, Massachusetts
Adrian R. Morrison
Affiliation:
University of Pennsylvania
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Summary

Summary

Sleep is a process occurring in all living animals. Although it is still controversial whether insects and other animals sleep alike; there is no doubt that they rest, as many studies in Drosophila melanogaster have shown. In this context, several seminal studies have documented species-dependent variations in sleep patterns. These findings along with obvious non-learned characteristics of sleep in general, such as the total time of sleep, the alternating NREM–REM sleep pattern, among many others, suggest strong regulation by genes. Clearly, the way genes may influence sleep physiology is via proteins. Hence, the importance of proteins in the regulation of sleep is observed in every minute event occurring to trigger or to maintain sleep. In this chapter we discuss families of proteins that are grouped by their effect on food ingestion, immunological response, trophic activity, and intracellular signaling, all of them affecting the sleep–waking cycle. Although we do not fully discuss the mechanisms of action, we put our effort in highlighting their effects on sleep. Along with the proteins and their effects we have listed those genes encoding them. We also show examples of proteins and the way they affect sleep. Hence, we hope that the overall message that readers will gather from this chapter is the importance of several proteins in the regulation of sleep. Also, by observing the effects of each family of proteins we can infer at least some functions of sleep and, finally, that sleep is a multigenic trait.

Type
Chapter
Information
Rapid Eye Movement Sleep
Regulation and Function
 , pp. 247 - 255
Publisher: Cambridge University Press
Print publication year: 2011

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