This chapter describes a growing body of work that demonstrates the efficacy of specific questions (“why” “why else?” and “what if?”) in supporting children’s ability to access their intuitive reasoning skills and apply them to tasks involving sophisticated causal and scientific thinking. We describe distinct mechanisms by which each of these questions results in unique types of inferences, and argue that each one has selective effects on a learner’s inferences, depending upon the evidence available, the state of their prior knowledge, and the relation of that prior knowledge to the true state of the world. We begin with a brief review of the well-established research on the efficacy of prompts for explanation, focusing on the developmental literature. We then offer a novel proposal, drawing on the adult research, that engaging children in the evaluation of alternative outcomes via prompting for multiple explanations or engagement with counterfactuals may provide a different avenue for fostering distinct sets of causal reasoning skills. Finally, we turn to a discussion of the relation between the content and process of children’s reasoning in response to these questions, and end with some suggestions for future research.