Book contents
- Frontmatter
- Contents
- Preface
- Figure Credits
- 1 Basic Properties of Quantum Chemistry
- 2 Charge Transport in the DNA Molecule
- 3 Electronic Transmission Spectra of the DNA Molecule
- 4 Thermodynamic Properties of the DNA Molecule
- 5 Properties of the DNA/RNA Nucleobases
- 6 Molecular Electronics
- 7 Amino Acid Anhydrous Crystals
- 8 Protein–Protein Systems
- 9 Ascorbic Acid and Ibuprofen Drugs
- 10 Cholesterol-Lowering Drugs
- 11 Collagen-Based Biomaterials
- 12 Antimigraine Drugs
- 13 Antiparkinson Drugs
- 14 Central Nervous System Disorders
- 15 The Biology of Cancer
- 16 Concluding Remarks
- Bibliography
- Index
6 - Molecular Electronics
Published online by Cambridge University Press: 21 January 2021
- Frontmatter
- Contents
- Preface
- Figure Credits
- 1 Basic Properties of Quantum Chemistry
- 2 Charge Transport in the DNA Molecule
- 3 Electronic Transmission Spectra of the DNA Molecule
- 4 Thermodynamic Properties of the DNA Molecule
- 5 Properties of the DNA/RNA Nucleobases
- 6 Molecular Electronics
- 7 Amino Acid Anhydrous Crystals
- 8 Protein–Protein Systems
- 9 Ascorbic Acid and Ibuprofen Drugs
- 10 Cholesterol-Lowering Drugs
- 11 Collagen-Based Biomaterials
- 12 Antimigraine Drugs
- 13 Antiparkinson Drugs
- 14 Central Nervous System Disorders
- 15 The Biology of Cancer
- 16 Concluding Remarks
- Bibliography
- Index
Summary
Using an effective tight-binding model, together with a transfer matrix technique, we investigate the electronic transport through oligopeptide chains, such as amino acid pairs and the Alpha3-helical polypeptide and its variants, sandwiched between two platinum electrodes. Our results show that factors such as the oligopeptide chain length and the possible combinations between the amino acids residues are crucial to the electronic conductance profiles. The temperature dependence of the electronic specific heat at constant volume spectra are also depicted. Applying our findings to single-stranded microRNAs (miRNAs) chains, which are associated to autism disorder, a relationship between the current intensity and the autism-related miRNA bases sequences is detected, suggesting that a kind of electronic biosensor can be developed to distinguish different profiles of autism spectrum disorders.
Keywords
- Type
- Chapter
- Information
- Quantum Chemistry Simulation of Biological Molecules , pp. 137 - 163Publisher: Cambridge University PressPrint publication year: 2021