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11 - Collagen-Based Biomaterials

Published online by Cambridge University Press:  21 January 2021

Eudenilson L. Albuquerque
Affiliation:
Universidade Federal do Rio Grande de Norte
Umberto L. Fulco
Affiliation:
Universidade Federal do Rio Grande de Norte
Ewerton W. S. Caetano
Affiliation:
Instituto Federal de Educação, Ciência e Tecnologia do Ceará
Valder N. Freire
Affiliation:
Universidade Federal do Ceará
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Summary

Collagen-based biomaterials are expected to become a useful matrix substance for various biomedical applications in the future. By taking advantage of the crystallographic data of the triple-helical peptide T3-785, a collagen-like peptide whose homotrimeric structure presents large conformational similarity to the human type III collagen, we present a quantum chemistry study to unveil its detailed binding energy features and conformation stability, considering the inter-chain interaction energies of 90 amino acid residues distributed into three interlaced monomers. Our theoretical model is based on the density functional theory formalism within the molecular fragmentation with conjugate caps approach. We present also its interaction with the integrin, a collagen receptor that facilitates cell-extracellular matrix adhesion, looking for the development and synthesis of artificial collagen with high stability for bioengineering applications. Besides, we depicted the relevance of each strand in the triple-helical collagen structure, helping the understanding of the events involving the integrin–collagen complex interaction energy.

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Publisher: Cambridge University Press
Print publication year: 2021

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