This chapter examines Puccini’s relationship with Milan, the city that was most important to his career. It begins with a detailed discussion of the Milan of the composer’s student years, outlining its importance as both an industrial and a cultural centre characterised by cosmopolitanism and modernity. Milan was also the capital of the nineteenth-century operatic world, where many singers, publishers, and critics were based, and with several leading opera houses, most notably La Scala. The chapter discusses how Puccini launched his career in Milan, securing a premiere at La Scala at a very early stage (Edgar). The ill-fated first performance of Madama Butterfly is also discussed, as is the posthumous premiere of Turandot. The chapter concludes with a discussion of the importance of Puccini’s oeuvre at La Scala since his death and the ways in which Puccini came, in a sense, to symbolise the city’s self-image.