Skip to main content Accessibility help
×
Hostname: page-component-78c5997874-j824f Total loading time: 0 Render date: 2024-11-09T06:27:55.404Z Has data issue: false hasContentIssue false

25 - The Drosophila eye and the genetics of schizophrenia

Published online by Cambridge University Press:  04 May 2010

Steven Matthysse
Affiliation:
Harvard University, Massachusetts
Francine M. Benes
Affiliation:
McClean Hospital
Deborah L. Levy
Affiliation:
Harvard University, Massachusetts
Jerome Kagan
Affiliation:
Harvard University, Massachusetts
Get access

Summary

Cognitive processing defects in schizophrenia

I would like to indulge in a little pole-vaulting across phyla, from Drosophila to schizophrenia. This familiar academic sport is usually played by the sellers of animal models, rather than the buyers; but as I work on schizophrenia and not on Drosophila, one unique feature of this exercise is that it will be from a buyer's point of view.

It seems to me (and many others) that schizophrenia is best understood as a failure of some aspects of what cognitive psychologists call automatic processing: the background of cognitive activity, carried out without awareness, that supports and facilitates conscious, effortful thought [32]. The existence of efficient cognitive preprocessing mechanisms is suggested by the ease and naturalness of thinking in normal people, despite the complex requirements thinking must meet to function competently. Our thought is able to navigate between Holzman's 20 categories of thought disorder [15, pp. 69-70]. Our memory can take advantage of context and predictability of word sequences, as Brendan Maher has observed (Chapter 19, this volume). Our language must conform to rules of syntax, semantics, logic and pragmatics. Nevertheless, ordinary thinking and speaking demand no special concentration and take hardly any time. We do not calculate before we speak, nor do we form our thoughts by a process of trial and error; we do not have to sift through a mixture of logical and illogical, grammatical and ungrammatical thoughts.

Type
Chapter
Information
Psychopathology
The Evolving Science of Mental Disorder
, pp. 557 - 580
Publisher: Cambridge University Press
Print publication year: 1996

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

Save book to Kindle

To save this book to your Kindle, first ensure [email protected] is added to your Approved Personal Document E-mail List under your Personal Document Settings on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part of your Kindle email address below. Find out more about saving to your Kindle.

Note you can select to save to either the @free.kindle.com or @kindle.com variations. ‘@free.kindle.com’ emails are free but can only be saved to your device when it is connected to wi-fi. ‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.

Find out more about the Kindle Personal Document Service.

Available formats
×

Save book to Dropbox

To save content items to your account, please confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account. Find out more about saving content to Dropbox.

Available formats
×

Save book to Google Drive

To save content items to your account, please confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account. Find out more about saving content to Google Drive.

Available formats
×