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7 - Immune responses to tumours: current concepts and applications

Published online by Cambridge University Press:  06 January 2010

Nigel Kirkham  and
Neil A. Shepherd
By
Elizabeth J. Soilleux
Nigel Kirkham
Affiliation:
Royal Victoria Infirmary, Newcastle
Neil A. Shepherd
Affiliation:
Gloucestershire Royal Hospital
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Information
Progress in Pathology , pp. 163 - 198
Publisher: Cambridge University Press
Print publication year: 2007

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References

Jager, D, Jager, E, Knuth, A. Immune responses to tumour antigens: implications for antigen specific immunotherapy of cancer. J Clin Pathol 2001; 54: 669–74.CrossRefGoogle ScholarPubMed
Boshoff, C, Weiss, R. AIDS-related malignancies. Nat Rev Cancer 2002; 2: 373–82.CrossRefGoogle ScholarPubMed
Jaffe, ES, International Agency for Research on Cancer. Pathology and Genetics of Tumours of Haematopoietic and Lymphoid Tissues (IARC Press, Lyon, 2001).Google Scholar
Venitt, S. Mechanisms of spontaneous human cancers. Environ Health Perspect 1996; 104 (Suppl 3): 633–7.CrossRefGoogle ScholarPubMed
Roitt, IM, Delves, PJ. Roitt's Essential Immunology (Blackwell Science, Malden, MA, 2001).Google Scholar
Goldsby, RA. Immunology (Freeman, New York, 2003).Google Scholar
Parham, P. The Immune System (Garland Publishing, New York, 2000).Google Scholar
Soilleux, EJ. DC-SIGN (dendritic cell-specific ICAM-grabbing non-integrin) and DC-SIGN-related (DC-SIGNR): friend or foe?Clin Sci (Lond) 2003; 104: 437–46.CrossRefGoogle ScholarPubMed
Hart, DN. Dendritic cells: unique leukocyte populations which control the primary immune response. Blood 1997; 90: 3245–87.Google ScholarPubMed
Cotran, RS, Kumar, V, Collins, T, Robbins, SL. Robbins Pathologic Basis of Disease (Saunders, Philadelphia, 1999).Google Scholar
Coventry, BJ, Austyn, JM, Chryssidis, S, Hankins, D, Harris, A. Identification and isolation of CD1a positive putative tumour infiltrating dendritic cells in human breast cancer. Adv Exp Med Biol 1997; 417: 571–7.CrossRefGoogle ScholarPubMed
Gilliet, M, Liu, YJ. Human plasmacytoid-derived dendritic cells and the induction of T-regulatory cells. Hum Immunol 2002; 63: 1149–55.CrossRefGoogle ScholarPubMed
Knight, SC, Askonas, BA, Macatonia, SE. Dendritic cells as targets for cytotoxic T lymphocytes. Adv Exp Med Biol 1997; 417: 389–94.CrossRefGoogle ScholarPubMed
Cooper, MA, Fehniger, TA, Caligiuri, MA. The biology of human natural killer-cell subsets. Trends Immunol 2001; 22: 633–40.CrossRefGoogle ScholarPubMed
Takanami, I, Takeuchi, K, Gika, M. Immunohistochemical detection of eosinophilic infiltration in pulmonary adenocarcinoma. Anticancer Res 2002; 22: 2391–6.Google ScholarPubMed
Hung, K, Hayashi, R, Lafond-Walker, Aet al. The central role of CD4(+) T-cells in the antitumor immune response. J Exp Med 1998; 188: 2357–68.CrossRefGoogle ScholarPubMed
Ancuta, P, Weiss, L, Haeffner-Cavaillon, N. CD14+CD16++ cells derived in vitro from peripheral blood monocytes exhibit phenotypic and functional dendritic cell-like characteristics. Eur J Immunol 2000; 30: 1872–83.3.0.CO;2-2>CrossRefGoogle ScholarPubMed
Linehan, SA, Martinez-Pomares, L, Stahl, PD, Gordon, S. Mannose receptor and its putative ligands in normal murine lymphoid and nonlymphoid organs: in situ expression of mannose receptor by selected macrophages, endothelial cells, perivascular microglia, and mesangial cells, but not dendritic cells. J Exp Med 1999; 189: 1961–72.CrossRefGoogle Scholar
Kawakami, T, Galli, SJ. Regulation of mast-cell and basophil function and survival by IgE. Nat Rev Immunol 2002; 2: 773–86.CrossRefGoogle ScholarPubMed
Hermes, B, Feldmann-Boddeker, I, Welker, Pet al. Altered expression of mast cell chymase and tryptase and of c-Kit in human cutaneous scar tissue. J Invest Dermatol 2000; 114: 51–5.CrossRefGoogle ScholarPubMed
Dimitriadou, V, Koutsilieris, M. Mast cell-tumor cell interactions: for or against tumour growth and metastasis?Anticancer Res 1997; 17: 1541–9.Google ScholarPubMed
Matzinger, P. The danger model: a renewed sense of self. Science 2002; 296: 301–5.CrossRefGoogle ScholarPubMed
Figdor, CG, Kooyk, Y, Adema, GJ. C-type lectin receptors on dendritic cells and Langerhans cells. Nat Rev Immunol 2002; 2: 77–84.CrossRefGoogle ScholarPubMed
Nguyen, LT, Elford, AR, Murakami, Ket al. Tumor growth enhances cross-presentation leading to limited T cell activation without tolerance. J Exp Med 2002; 195: 423–35.CrossRefGoogle ScholarPubMed
Janeway, CA Jr.The immune system evolved to discriminate infectious nonself from noninfectious self. Immunol Today 1992; 13: 11–16.CrossRefGoogle ScholarPubMed
Kirschning, CJ, Schumann, RR. TLR2: cellular sensor for microbial and endogenous molecular pattrns. Curr Top Microbiol Immunol 2002; 270: 121–44.Google Scholar
Termeer, Cet al. Oligosaccharides of Hyaluronan activate dendritic cells via toll-like receptor 4. J Exp Med 2002; 195: 99–111.CrossRefGoogle ScholarPubMed
Basu, S, Binder, RJ, Suto, R, Anderson, KM, Srivastava, PK. Necrotic but not apoptotic cell death releases heat shock proteins, which deliver a partial maturation signal to dendritic cells and activate the NF-kappa B pathway. Int Immunol 2000; 12: 1539–46.CrossRefGoogle Scholar
Fuchs, EJ, Matzinger, P. Is cancer dangerous to the immune system?Semin Immunol 1996; 8: 271–80.CrossRefGoogle ScholarPubMed
Sahin, U, Tureci, O, Schmitt, Het al. Human neoplasms elicit multiple specific immune responses in the autologous host. Proc Natl Acad Sci USA 1995; 92: 11810–13.CrossRefGoogle ScholarPubMed
Rosenberg, SA. Progress in the development of immunotherapy for the treatment of patients with cancer. J Intern Med 2001; 250: 462–75.CrossRefGoogle ScholarPubMed
Yee, C, Greenberg, P. Modulating T-cell immunity to tumours: new strategies for monitoring T-cell responses. Nat Rev Cancer 2002; 2: 409–19.CrossRefGoogle ScholarPubMed
Kiessling, A, Schmitz, M, Stevanovic, Set al. Prostate stem cell antigen: identification of immunogenic peptides and assessment of reactive CD8+ T cells in prostate cancer patients. Int J Cancer 2002; 102: 390–7.CrossRefGoogle ScholarPubMed
Nelson, PS. Identifying immunotherapeutic targets for prostate carcinoma through the analysis of gene expression profiles. Ann NY Acad Sci 2002; 975: 232–46.CrossRefGoogle ScholarPubMed
Bonner, PL, Lill, JR, Hill, S, Creaser, CS, Rees, RC. Electrospray mass spectrometry for the identification of MHC class I-associated peptides expressed on cancer cells. J Immunol Methods 2002; 262: 5–19.CrossRefGoogle ScholarPubMed
Preuss, KD, Zwick, C, Bormann, C, Neumann, F, Pfreundschuh, M. Analysis of the B-cell repertoire against antigens expressed by human neoplasms. Immunol Rev 2002; 188: 43–50.CrossRefGoogle ScholarPubMed
Mazzocchi, A, Storkus, WJ, Traversari, Cet al. Multiple melanoma-associated epitopes recognized by HLA-A3-restricted CTLs and shared by melanomas but not melanocytes. J Immunol 1996; 157: 3030–8.Google Scholar
Ruffini, PA, Neelapu, SS, Kwak, LW, Biragyn, A. Idiotypic vaccination for B-cell malignancies as a model for therapeutic cancer vaccines: from prototype protein to second generation vaccines. Haematologica 2002; 87: 989–1001.Google ScholarPubMed
Blanke, CD, Eisenberg, BL, Heinrich, MC. Gastrointestinal stromal tumors. Curr Treat Options Oncol 2001; 2: 485–91.CrossRefGoogle ScholarPubMed
Eisenbach, L, Bar-Haim, E, El-Shami, K. Antitumor vaccination using peptide based vaccines. Immunol Lett 2000; 74: 27–34.CrossRefGoogle ScholarPubMed
Rickinson, AB. Immune intervention against virus-associated human cancers. Ann Oncol 1995; 6(Suppl 1): 69–71.CrossRefGoogle ScholarPubMed
Imahayashi, S, Ichiyoshi, Y, Yoshino, Iet al. Tumor-infiltrating B-cell-derived IgG recognizes tumor components in human lung cancer. Cancer Invest 2000; 18: 530–6.CrossRefGoogle ScholarPubMed
Coronella, JAet al. Evidence for an antigen-driven humoral immune response in medullary ductal breast cancer. Cancer Res 2001; 61: 7889–99.Google ScholarPubMed
O'Brien, PM, Tsirimonaki, E, Coomber, DWet al. Immunoglobulin genes expressed by B-lymphocytes infiltrating cervical carcinomas show evidence of antigen-driven selection. Cancer Immunol Immunother 2001; 50: 523–32.CrossRefGoogle ScholarPubMed
Petty, JK, He, K, Corless, CL, Vetto, JT, Weinberg, AD. Survival in human colorectal cancer correlates with expression of the T-cell costimulatory molecule OX-40 (CD134). Am J Surg 2002; 183: 512–18.CrossRefGoogle Scholar
Kuo, SH, Chang, DB, Lee, YC, Lee, YT, Luh, KT. Tumour-infiltrating lymphocytes in non-small cell lung cancer are activated T lymphocytes. Respirology 1998; 3: 55–9.CrossRefGoogle ScholarPubMed
Gaffey, MJ, Frierson, HF Jr, Mills, SEet al. Medullary carcinoma of the breast. Identification of lymphocyte subpopulations and their significance. Mod Pathol 1993; 6: 721–8.Google ScholarPubMed
Yannelli, JRet al. Growth of tumor-infiltrating lymphocytes from human solid cancers: summary of a 5-year experience. Int J Cancer 1996; 65: 413–21.3.0.CO;2-#>CrossRefGoogle ScholarPubMed
Suekane, S, Nakao, M, Inoue, M, Noda, S, Itoh, K. Histocompatibility leukocyte antigen-A2-restricted and tumor-specific cytotoxic T lymphocytes from tumor-infiltrating lymphocytes of patient with testicular embryonal cancer. Jpn J Cancer Res 1997; 88: 1181–9.CrossRefGoogle ScholarPubMed
Dadmarz, RD, Ordoubadi, A, Mixon, Aet al. Tumor-infiltrating lymphocytes from human ovarian cancer patients recognize autologous tumor in an MHC Class II-restricted fashion. Cancer J Sci Am 1996; 2: 263.Google Scholar
Boon, T, Cerottini, JC, Eynde, B, Bruggen, P, Pel, A. Tumor antigens recognized by T lymphocytes. Annu Rev Immunol 1994; 12: 337–65.CrossRefGoogle ScholarPubMed
Topalian, SL, Rivoltini, L, Mancini, Met al. Human CD4+ T-cells specifically recognize a shared melanoma-associated antigen encoded by the tyrosinase gene. Proc Natl Acad Sci USA 1994; 91: 9461–5.CrossRefGoogle ScholarPubMed
Hasenkrug, KJ, Brooks, DM, Dittmer, U. Critical role for CD4(+) T-cells in controlling retrovirus replication and spread in persistently infected mice. J Virol 1998; 72: 6559–64.Google ScholarPubMed
Dunn, GP, Bruce, AT, Ikeda, H, Old, LJ, Schreiber, RD. Cancer immunoediting: from immunosurveillance to tumor escape. Nat Immunol 2002; 3: 991–8.CrossRefGoogle ScholarPubMed
Hohn, H, Pilch, H, Gunzel, Set al. CD4+ tumor-infiltrating lymphocytes in cervical cancer recognize HLA-DR-restricted peptides provided by human papillomavirus-E7. J Immunol 1999; 163: 5715–22.Google ScholarPubMed
Street, SE, Trapani, JA, MacGregor, D, Smyth, MJ. Suppression of lymphoma and epithelial malignancies effected by interferon gamma. J Exp Med 2002; 196: 129–34.CrossRefGoogle ScholarPubMed
Zeng, G. MHC Class II-restricted tumor antigens recognized by CD4+ T cells: new strategies for cancer vaccine design. J Immunother 2001; 24: 195–204.CrossRefGoogle ScholarPubMed
Khong, HT, Restifo, NP. Natural selection of tumor variants in the generation of “tumor escape” phenotypes. Nat Immunol 2002; 3: 999–1005.CrossRefGoogle ScholarPubMed
Dionne, SO, Smith, MH, Marincola, FM, Lake, DF, Antigen presentation of a modified tumor-derived peptide by tumor infiltrating lymphocytes. Cell Immunol 2001; 214: 139–44.CrossRefGoogle ScholarPubMed
Kooi, S, Zhang, HZ, Patenia, Ret al. HLA class I expression on human ovarian carcinoma cells correlates with T-cell infiltration in vivo and T-cell expansion in vitro in low concentrations of recombinant interleukin-2. Cell Immunol 1996; 174: 116–28.CrossRefGoogle Scholar
Kuge, Set al. Interleukin-12 augments the generation of autologous tumor-reactive CD8+ cytotoxic T lymphocytes from tumor-infiltrating lymphocytes. Jpn J Cancer Res 1995; 86: 135–9.CrossRefGoogle ScholarPubMed
Shimizu, Y, Weidmann, E, Iwatsuki, S, Herberman, RB, Whiteside, TL. Characterization of human autotumor-reactive T-cell clones obtained from tumor-infiltrating lymphocytes in liver metastasis of gastric carcinoma. Cancer Res 1991; 51: 6153–62.Google ScholarPubMed
Enomoto, A, Kato, K, Yagita, H, Okumura, K. Adoptive transfer of cytotoxic T lymphocytes induced by CD86-transfected tumor cells suppresses multi-organ metastases of C1300 neuroblastoma in mice. Cancer Immunol Immunother 1997; 44: 204–10.CrossRefGoogle ScholarPubMed
Kohda, H, Sekiya, C, Torimoto, Yet al. Importance of cytotoxic T lymphocytes in the rejection of transplanted hepatocellular carcinoma. J Gastroenterol 1994; 29: 282–8.CrossRefGoogle ScholarPubMed
Rees, RC, Mian, S. Selective MHC expression in tumours modulates adaptive and innate antitumour responses. Cancer Immunol Immunother 1999; 48: 374–81.CrossRefGoogle ScholarPubMed
Ferrarini, M, Ferrero, E, Dagna, L, Poggi, A, Zocchi, MR. Human gammadelta T cells: a nonredundant system in the immune-surveillance against cancer. Trends Immunol 2002; 23: 14–18.CrossRefGoogle ScholarPubMed
Schiltz, PM, Beutel, LD, Nayak, SK, Dillman, RO. Characterization of tumor-infiltrating lymphocytes derived from human tumors for use as adoptive immunotherapy of cancer. J Immunother 1997; 20: 377–86.CrossRefGoogle ScholarPubMed
Lee, RS, Schlumberger, M, Caillou, Bet al. Phenotypic and functional characterisation of tumour-infiltrating lymphocytes derived from thyroid tumours. Eur J Cancer 1996; 32A: 1233–9.CrossRefGoogle ScholarPubMed
Hald, J, Rasmussen, N, Claesson, MH. Tumour-infiltrating lymphocytes mediate lysis of autologous squamous cell carcinomas of the head and neck. Cancer Immunol Immunother 1995; 41: 243–50.CrossRefGoogle ScholarPubMed
Hilders, CG, Ras, L, Eendenburg, JD, Nooyen, Y, Fleuren, GJ. Isolation and characterization of tumor-infiltrating lymphocytes from cervical carcinoma. Int J Cancer 1994; 57: 805–13.CrossRefGoogle ScholarPubMed
Nakashima, M, Janiszewska, M, Steplewski, Zet al. Proliferation, phenotype, and cytotoxicity of human lymphocytes isolated from lymph nodes invaded by melanoma cells. Hybridoma 1994; 13: 241–6.CrossRefGoogle ScholarPubMed
Karimine, N, Nanbara, S, Arinaga, Set al. Lymphokine-activated killer cell activity of peripheral blood, spleen, regional lymph node, and tumor infiltrating lymphocytes in gastric cancer patients. J Surg Oncol 1994; 55: 179–85.CrossRef
Ostenstad, B, Lea, T, Schlichting, E, Harboe, M. Human colorectal tumour infiltrating lymphocytes express activation markers and the CD45RO molecule, showing a primed population of lymphocytes in the tumour area. Gut 1994; 35: 382–7.CrossRefGoogle ScholarPubMed
Hayakawa, K, Salmeron, MA, Parkinson, DRet al. Study of tumor-infiltrating lymphocytes for adoptive therapy of renal cell carcinoma (RCC) and metastatic melanoma: sequential proliferation of cytotoxic natural killer and noncytotoxic T-cells in RCC. J Immunother 1991; 10: 313–25.CrossRefGoogle ScholarPubMed
Ljunggren, HG, Ohlen, C, Hoglund, Pet al. Afferent and efferent cellular interactions in natural resistance directed against MHC class I deficient tumor grafts. J Immunol 1998; 140: 671–8.Google Scholar
Mather, GG, Talcott, PA, Exon, JH. Characterization of a chemically induced tumor model and the effects of natural killer cell depletion by antiasialo GM-1. Immunobiology 1994; 190: 333–45.CrossRefGoogle ScholarPubMed
Kusmartsev, S, Gabrilovich, DI. Immature myeloid cells and cancer-associated immune suppression. Cancer Immunol Immunother 2002; 51: 293–8.CrossRefGoogle ScholarPubMed
Zou, W, Machelon, V, Coulomb-L'Hermin, Aet al. Stromal-derived factor-1 in human tumors recruits and alters the function of plasmacytoid precursor dendritic cells. Nat Med 2001; 7: 1339–46.CrossRefGoogle ScholarPubMed
Salio, M, Cella, M, Vermi, Wet al. Plasmacytoid dendritic cells prime IFN-gamma-secreting melanoma-specific CD8 lymphocytes and are found in primary melanoma lesions. Eur J Immunol 2003; 33: 1052–62.CrossRefGoogle ScholarPubMed
Clark, WH Jr, Elder, , Guerry, D 4thet al. Model predicting survival in stage I melanoma based on tumor progression. J Natl Cancer Inst 1989; 81: 1893–904.CrossRefGoogle Scholar
Clemente, CG, Mihm, MC Jr, Bufalino, Ret al. Prognostic value of tumor infiltrating lymphocytes in the vertical growth phase of primary cutaneous melanoma. Cancer 1996; 77: 1303–10.3.0.CO;2-5>CrossRefGoogle ScholarPubMed
Menard, S, Tomasic, G, Casalini, Pet al. Lymphoid infiltration as a prognostic variable for early-onset breast carcinomas. Clin Cancer Res 1997; 3: 817–19.Google ScholarPubMed
Branston, LK, Greening, S, Newcombe, RGet al. The implementation of guidelines and computerised forms improves the completeness of cancer pathology reporting. The CROPS project: a randomised controlled trial in pathology. Eur J Cancer 2002; 38: 764–72.CrossRefGoogle ScholarPubMed
Halliday, GM, Patel, A, Hunt, MJ, Tefany, FJ, Barnetson, RS. Spontaneous regression of human melanoma/nonmelanoma skin cancer: association with infiltrating CD4+ T-cells. World J Surg 1995; 19: 352–8.CrossRefGoogle ScholarPubMed
Patel, A, Halliday, GM, Cooke, BE, Barnetson, RS. Evidence that regression in keratoacanthoma is immunologically mediated: a comparison with squamous cell carcinoma. Br J Dermatol 1994; 131: 789–98.CrossRefGoogle ScholarPubMed
Furihata, M, Ohtsuki, Y, Sonobe, Het al. Prognostic significance of simultaneous infiltration of HLA-DR-positive dendritic cells and tumor infiltrating lymphocytes into human esophageal carcinoma. Tohoku J Exp Med 1993; 169: 187–95.CrossRefGoogle ScholarPubMed
Ishigami, S, Natsugoe, S, Tokuda, Ket al. CD3-zetachain expression of intratumoral lymphocytes is closely related to survival in gastric carcinoma patients. Cancer 2002; 94: 1437–42.CrossRefGoogle ScholarPubMed
Funada, Y, Noguchi, T, Kikuchi, Ret al. Prognostic significance of CD8+ T cell and macrophage peritumoral infiltration in colorectal cancer. Oncol Rep 2003; 10: 309–13.Google ScholarPubMed
Epstein, NA, Fatti, LP. Prostatic carcinoma: some morphological features affecting prognosis. Cancer 1976; 37: 2455–65.3.0.CO;2-V>CrossRefGoogle ScholarPubMed
Vesalainen, S, Lipponen, P, Talja, M, Syrjanen, K. Histological grade, perineural infiltration, tumour-infiltrating lymphocytes and apoptosis as determinants of long-term prognosis in prostatic adenocarcinoma. Eur J Cancer 1994; 30A, 1797–803.CrossRefGoogle ScholarPubMed
Bansberg, SF, Olsen, KD, Gaffey, TA. Lymphoepithelioma of the oropharynx. Otolaryngol Head Neck Surg 1989; 100: 303–7.CrossRefGoogle ScholarPubMed
Ahuja, AT, Teo, PM, To, KF, King, AD, Metreweli, C. Palatal lymphoepitheliomas and a review of head and neck lymphoepitheliomas. Clin Radiol 1999; 54: 289–93.CrossRefGoogle Scholar
Bernstorff, W, Voss, M, Freichel, S. Systemic and local immunosuppression in pancreatic cancer patients. Clin Cancer Res 2001; 7: 925s–32s.Google Scholar
Mihm MC, , Clemente CG, Cascinelli N. Tumor infiltrating lymphocytes in lymph node melanoma metastases: a histopathologic prognostic indicator and an expression of local immune response. Lab Invest 1996; 74: 43–7.Google ScholarPubMed
Finn, OJ, Forni, G. Prophylactic cancer vaccines. Curr Opin Immunol 2002; 14: 172–7.CrossRefGoogle ScholarPubMed
Koutsky, et al. A controlled trial of a human papillomavirus type 16 vaccine. N Engl J Med 2002; 347: 1645–51.CrossRefGoogle ScholarPubMed
Schuler, G, Schuler-Thurner, B, Steinman, RM. The use of dendritic cells in cancer immunotherapy. Curr Opin Immunol 2003; 15: 138–47.CrossRefGoogle ScholarPubMed
Pardoll, DM. Spinning molecular immunology into successful immunotherapy. Nat Rev Immunol 2002; 2: 227–38.CrossRefGoogle ScholarPubMed
Paul, S, Calmels, B, Acres, RB. Improvement of adoptive cellular immunotherapy of human cancer using ex-vivo gene transfer. Curr Gene Ther 2002; 2: 91–100.CrossRefGoogle ScholarPubMed
Yu, Z, Restifo, NP. Cancer vaccines: progress reveals new complexities. J Clin Invest 2002; 110: 289–94.CrossRefGoogle ScholarPubMed
Schamhart, DH, Boer, EC, Reijke, TM, Kurth, K. Urinary cytokines reflecting the immunological response in the urinary bladder to biological response modifiers: their practical use. Eur Urol 2000; 37(Suppl 3): 16–23.CrossRefGoogle ScholarPubMed
Carter, P. Improving the efficacy of antibody-based cancer therapies. Nat Rev Cancer 2001; 1: 118–29.CrossRefGoogle ScholarPubMed
Turk, MJ, Wolchok, JD, Guevara-Patino, JA, Goldberg, SM, Houghton, AN. Multiple pathways to tumor immunity and concomitant autoimmunity. Immunol Rev 2002; 188: 122–35.CrossRefGoogle ScholarPubMed
Newton, R, Ziegler, J, Ateenyi-Agaba, Cet al. The epidemiology of conjunctival squamous cell carcinoma in Uganda. Br J Cancer 2002; 87: 301–8.CrossRefGoogle ScholarPubMed
Mbulaiteye, SM, Parkin, DM, Rabkin, CS. Epidemiology of AIDS-related malignancies an international perspective. Hematol Oncol Clin North Am 2003; 17: 673–96, v.CrossRefGoogle ScholarPubMed
Goedert, JJ. The epidemiology of acquired immunodeficiency syndrome malignancies. Semin Oncol 2000; 27: 390–401.Google ScholarPubMed
Ishida, H, Matsumura, T, Salgaller, MLet al. MAGE-1 and MAGE-3 or -6 expression in neuroblastoma-related pediatric solid tumors. Int J Cancer 1996; 69: 375–80.3.0.CO;2-2>CrossRefGoogle ScholarPubMed
Jager, E, Jager, D, Knuth, A. Clinical cancer vaccine trials. Curr Opin Immunol 2002; 14: 178–82.CrossRefGoogle ScholarPubMed
Reichert, TE, Day, R, Wagner, EM, Whiteside, TL. Absent or low expression of the zeta chain in T cells at the tumor site correlates with poor survival in patients with oral carcinoma. Cancer Res 1998; 58: 5344–7.Google ScholarPubMed
Sarioglu, T, Yilmaz, T, Sungur, A, Gursel, B. The effect of lymphocytic infiltration on clinical survival in cancer of the tongue. Eur Arch Otorhinolaryngol 1994; 251: 366–9.Google ScholarPubMed
Grogg, KL, Lohse, CM, Pankratz, VS, Halling, KC, Smyrk, TC. Lymphocyte-rich gastric cancer: associations with Epstein–Barr virus, microsatellite instability, histology, and survival. Mod Pathol 2003; 16: 641–51.CrossRefGoogle Scholar
Wang, HH, Wu, MS, Shun, CTet al. Lymphoepithelioma-like carcinoma of the stomach: a subset of gastric carcinoma with distinct clinicopathological features and high prevalence of Epstein–Barr virus infection. Hepatogastroenterology 1999; 46: 1214–19.Google ScholarPubMed
Yin, XY, Lu, MD, Lai, YR, Liang, LJ, Huang, JF. Prognostic significances of tumor-infiltrating S-100 positive dendritic cells and lymphocytes in patients with hepatocellular carcinoma. Hepatogastroenterology 2003 Sep–Oct; 50(53): 1281–4.Google Scholar
Jass, JR. Pathology of hereditary nonpolyposis colorectal cancer. Ann NY Acad Sci 2000; 910: 62–73; discussion 73–4.CrossRefGoogle ScholarPubMed
Michael-Robinson, JM, Biemer-Huttmann, A, Purdie, DMet al. Tumour infiltrating lymphocytes and apoptosis are independent features in colorectal cancer stratified according to microsatellite instability status. Gut 2001; 48: 360–6.CrossRefGoogle ScholarPubMed
Coca, S, Perez-Piqueras, J, Martinez, Det al. The prognostic significance of intratumoral natural killer cells in patients with colorectal carcinoma. Cancer 1997; 79: 2320–8.3.0.CO;2-P>CrossRefGoogle ScholarPubMed
Mori, M, Ohtani, H, Naito, Yet al. Infiltration of CD8+ T-cells in non-small cell lung cancer is associated with dedifferentiation of cancer cells, but not with prognosis. Tohoku J Exp Med 2000; 191: 113–18.CrossRefGoogle Scholar
Toomey, D, Smyth, G, Condron, Cet al. Infiltrating immune cells, but not tumour cells, express FasL in non-small cell lung cancer: no association with prognosis identified in 3-year follow-up. Int J Cancer 2003; 103: 408–12.CrossRefGoogle Scholar
Eerola, AK, Soini, Y, Paakko, P. A high number of tumor-infiltrating lymphocytes are associated with a small tumor size, low tumor stage, and a favorable prognosis in operated small cell lung carcinoma. Clin Cancer Res 2000; 6: 1875–81.Google Scholar
Villegas, FR, Coca, S, Villarrubia, VGet al. Prognostic significance of tumor infiltrating natural killer cells subset CD57 in patients with squamous cell lung cancer. Lung Cancer 2002; 35: 23–8.CrossRefGoogle ScholarPubMed
Takanami, I, Takeuchi, K, Giga, M. The prognostic value of natural killer cell infiltration in resected pulmonary adenocarcinoma. J Thorac Cardiovasc Surg 2001; 121: 1058–63.CrossRefGoogle ScholarPubMed
Eerola, AK, Soini, Y, Paakko, P. Tumour infiltrating lymphocytes in relation to tumour angiogenesis, apoptosis and prognosis in patients with large cell lung carcinoma. Lung Cancer 1999; 26: 73–83.CrossRefGoogle ScholarPubMed
Zeid, NA, Muller, HK. S100 positive dendritic cells in human lung tumors associated with cell differentiation and enhanced survival. Pathology 1993; 25: 338–43.CrossRefGoogle ScholarPubMed
Han, AJ, Xiong, M, Gu, YY, Lin, SX. Lymphoepithelioma-like carcinoma of the lung with a better prognosis. A clinicopathologic study of 32 cases. Am J Clin Pathol 2001; 115: 841–50.CrossRefGoogle ScholarPubMed
Deligdisch, L, Jacobs, AJ, Cohen, CJ. Histologic correlates of virulence in ovarian adenocarcinoma. II. Morphologic correlates of host response. Am J Obstet Gynecol 1982; 144: 885–9.CrossRefGoogle ScholarPubMed
Dundar, E, Tel, N, Ozalp, SSet al. The significance of local cellular immune response of women 50 years of age and younger with endometrial carcinoma. Eur J Gynaecol Oncol 2002; 23: 243–6.Google ScholarPubMed
Bethwaite, PB, Holloway, LJ, Thornton, A, Delahunt, B. Infiltration by immunocompetent cells in early stage invasive carcinoma of the uterine cervix: a prognostic study. Pathology 1996; 28: 321–7.CrossRefGoogle ScholarPubMed
Husseinzadeh, N, Wesseler, T, Schellhas, H, Nahhas, W. Significance of lymphoplasmocytic infiltration around tumor cell in the prediction of regional lymph node metastases in patients with invasive squamous cell carcinoma of the vulva: a clinicopathologic study. Gynecol Oncol 1989; 34: 200–5.CrossRefGoogle ScholarPubMed
Evensen, JF, Fossa, SD, Kjellevold, K, Lien, HH. Testicular seminoma: histological findings and their prognostic significance for stage II disease. J Surg Oncol 1987; 36: 166–9.CrossRefGoogle ScholarPubMed
Kolbeck, PC, Kaveggia, FF, Johansson, SL, Grune, MT, Taylor, RJ. The relationships among tumor-infiltrating lymphocytes, histopathologic findings, and long-term clinical follow-up in renal cell carcinoma. Mod Pathol 1992; 5: 420–5.Google ScholarPubMed
Tomita, K, Okui, N, Kimura, Aet al. Prognostic significance of histopathological findings (including lymphocyte infiltration) in renal cell carcinoma. Hinyokika Kiyo 1996; 42: 925–30.Google Scholar
Lipponen, PK, Eskelinen, MJ, Jauhiainen, K, Harju, E, Terho, R. Tumour infiltrating lymphocytes as an independent prognostic factor in transitional cell bladder cancer. Eur J Cancer 1992; 29A: 69–75.Google ScholarPubMed
Nzula, S, Going, JJ, Stott, DI. Antigen-driven clonal proliferation, somatic hypermutation, and selection of B lymphocytes infiltrating human ductal breast carcinomas. Cancer Res 2003; 63: 3275–80.Google ScholarPubMed
Lawry, J, Rogers, K, Duncan, JL, Potter, CW. The identification of informative parameters in the flow cytometric analysis of breast carcinoma. Eur J Cancer 1993; 29A: 719–23.CrossRefGoogle ScholarPubMed
Lucin, K, Iternicka, Z, Jonjic, N. Prognostic significance of T-cell infiltrates, expression of beta 2-microglobulin and HLA-DR antigens in breast carcinoma. Pathol Res Pract 1994; 190: 1134–40.CrossRefGoogle ScholarPubMed
Lowe, D, Jorizzo, J, Hutt, MS. Tumour-associated eosinophilia: a review. J Clin Pathol 1981; 34: 1343–8.CrossRefGoogle ScholarPubMed
Menard, S, Fortis, S, Castiglioni, F, Agresti, R, Balsari, A. HER2 as a prognostic factor in breast cancer. Oncology 2001; 61(Suppl 2): 67–72.CrossRefGoogle ScholarPubMed
Tang, RP, Kacinski, B, Validire, Pet al. Oncogene amplification correlates with dense lymphocyte infiltration in human breast cancers: a role for hematopoietic growth factor release by tumor cells?J Cell Biochem 1990; 44: 189–98.CrossRefGoogle ScholarPubMed
Rossi, ML, Jones, NR, Candy, Eet al. The mononuclear cell infiltrate compared with survival in high-grade astrocytomas. Acta Neuropathol (Berl) 1989; 78: 189–93.CrossRefGoogle ScholarPubMed
Mork, SJ, Halvorsen, TB, Lindegaard, KF, Eide, GE. Oligodendroglioma. Histologic evaluation and prognosis. J Neuropathol Exp Neurol 1986; 45: 65–78.CrossRefGoogle ScholarPubMed
Brooks, WH, Markesbery, WR, Gupta, GD, Roszman, TL. Relationship of lymphocyte invasion and survival of brain tumor patients. Ann Neurol 1978; 4: 219–24.CrossRefGoogle ScholarPubMed
Palma, L, Di Lorenzo, N, Guidetti, B. Lymphocytic infiltrates in primary glioblastomas and recidivous gliomas. Incidence, fate, and relevance to prognosis in 228 operated cases. J Neurosurg 1978; 49: 854–61.CrossRefGoogle ScholarPubMed
Di Lorenzo, N, Palma, L, Nicole, S. Lymphocytic infiltration in long-survival glioblastomas: possible host's resistance. Acta Neurochir (Wien) 1977; 39: 27–33.CrossRefGoogle Scholar
Vaquero, J, Coca, S, Oya, Set al. Presence and significance of NK cells in glioblastomas. J Neurosurg 1989; 70: 728–31.CrossRefGoogle ScholarPubMed

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