Skip to main content Accessibility help
×
Hostname: page-component-586b7cd67f-rdxmf Total loading time: 0 Render date: 2024-11-26T03:20:43.388Z Has data issue: false hasContentIssue false

Chapter 10 - The genetics of the phobic disorders and generalized anxiety disorder

Published online by Cambridge University Press:  05 October 2012

John I. Nurnberger, Jr
Affiliation:
Indiana University School of Medicine
Wade Berrettini
Affiliation:
University of Pennsylvania School of Medicine
Get access

Summary

Genetic epidemiology can address a number of questions of practical importance for a search for genes for phobic disorders. With the genetics of the phobic disorders established, studies are beginning to ask more specifically what constitutes the additive genetic component. Genome searches have been reported for agoraphobia, simple phobia, social phobia, and for a broad phenotype that includes these three phobias in addition to other anxiety disorders. Genetic epidemiology indicates that finding genes for the phobic disorders will require samples with considerable statistical power since the heritability's of these disorders are modest. Twin studies indicate that the familial transmission of generalized anxiety disorder (GAD) is due to genes. With regard to GAD, additive genes shared with panic disorder and agoraphobia accounted for 20% of the total variance of GAD; indeed, this shared variance component made up 87% of its additive genetic variance.
Type
Chapter
Information
Publisher: Cambridge University Press
Print publication year: 2012

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

Save book to Kindle

To save this book to your Kindle, first ensure [email protected] is added to your Approved Personal Document E-mail List under your Personal Document Settings on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part of your Kindle email address below. Find out more about saving to your Kindle.

Note you can select to save to either the @free.kindle.com or @kindle.com variations. ‘@free.kindle.com’ emails are free but can only be saved to your device when it is connected to wi-fi. ‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.

Find out more about the Kindle Personal Document Service.

Available formats
×

Save book to Dropbox

To save content items to your account, please confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account. Find out more about saving content to Dropbox.

Available formats
×

Save book to Google Drive

To save content items to your account, please confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account. Find out more about saving content to Google Drive.

Available formats
×