Optimization of procedures routinely performed in a clinical human in vitro fertilization (IVF) laboratory have become increasingly important due to the increase in complexity of procedures now performed in the laboratory. The addition of new technologies requiring more oversight has increased dramatically within the last decade. As a result of incorporating these new technologies, safe and efficient operation of the IVF laboratory has become increasingly complex and requires a substantial understanding of processes within the laboratory. In today’s modern IVF laboratory, the amount of staff time to perform every increasingly complicated case has more than doubled. Similarly, the amount required time to prepare for these cases has increased dramatically as well. In many instances, the increase in complexity of laboratory procedures has not translated into hiring of new staff but the creation of challenges to improve efficiency within the laboratory. The current guidelines for allocation of staff are based upon cycle numbers performed on an annual basis, not complexity of cases performed.