In a low-risk patient with negative cell-free DNA screening for Down syndrome, the finding of an isolated soft marker on second-trimester ultrasound such as a single echogenic intracardiac focus is not clinically significant. In the absence of other abnormal ultrasound findings, no follow-up testing is recommended for this isolated result. Reassurance can be provided to the patient. In the era of immediate release of ultrasound reports with the electronic medical record, anticipatory guidance regarding possible findings can be reviewed with patients at the time of ordering tests and studies to reduce anxiety.