We discuss the case of a postpartum patient that develops posterior reversible encephalopathy syndrome (PRES) as characterized by clinical and neuro-radiological findings. It is described as an acute or subacute syndrome that presents with elevated blood pressure and symptoms of headache, altered mental status, seizures, and vision changes. Diagnosis of PRES is made with neuroimaging, with magnetic resonance imaging being the preferred modality. Pathognomonic imaging includes findings of posterior encephalopathy. There is a strong correlation of PRES in patients with preeclampsia and eclampsia. The syndrome can be reversed with timely and aggressive control of symptoms and underlying causes, which in this case included blood pressure control as well as seizure prophylaxis.