Published online by Cambridge University Press: 14 November 2024
Topical applications of drugs onto the corneal surface will act directly on the neuromuscular junction of the iris muscles. The responses are dramatic, except for a few drugs that are metabolized by enzymes in the anterior chamber. This method was essential toward our understanding of how drugs act to produce their pharmacological effects. The action of systemically administered drugs is complicated by side effects of sedation and arousal. Pupillary reflexes have been proposed as a method to evaluate drug intoxications.
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