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Chapter 2 - Post-traumatic Epilepsy: Epidemiology, Definition and Terminology

Published online by Cambridge University Press:  10 August 2021

Marco Mula
Affiliation:
St George's Hospital Medical School, University of London
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Summary

Traumatic brain injury (TBI) is a major risk factor for the development of epilepsy, accounting for around 5% of all epilepsy cases. The risk is greatest within the first year of injury but persists for many years afterwards. Severity of injury is the biggest predictor of future risk of epilepsy, with evidence of intracerebral and sub-dural haemorrhage being important clinical indicators. Individual characteristics including medical co-morbidities and genetic predisposition also influence this risk.

TBI-related seizures are separated into those arising within the first week of injury (early post-traumatic seizures) and those happening later (late post-traumatic seizures). This distinction is useful because early post-traumatic seizures do not appear to be an independent risk factor for the future development of epilepsy. However, the risk of further seizures after a single late post-traumatic seizure is as high as 80%. Therefore, one late post-traumatic seizure signals an increased predisposition to generate future epileptic seizures. This fulfils the criteria for diagnosing epilepsy and the individual should be counselled and treated accordingly.

In this chapter, we discuss the classification of epilepsy and TBI severity before summarising the largest epidemiological studies that have attempted to ascertain the incidence and prevalence of post-traumatic epilepsy and the major risk factors.

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Publisher: Cambridge University Press
Print publication year: 2021

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References

Annegers, JF, Hauser, WA, Coan, SP, Rocca, WA. A population-based study of seizures after traumatic brain injuries. N Engl J Med 1998; 338: 20–4.CrossRefGoogle ScholarPubMed
Asikainen, I, Kaste, M, Sarna, S. Early and late posttraumatic seizures in traumatic brain injury rehabilitation patients: Brain injury factors causing late seizures and influence of seizures on long-term outcome. Epilepsia 1999; 40: 584–9.CrossRefGoogle ScholarPubMed
Englander, J, Bushnik, T, Wright, JM, Jamison, L, Duong, TT. Mortality in late post-traumatic seizures. J Neurotrauma 2009; 26: 1471–7.Google Scholar
Haltiner, AM, Temkin, NR, Dikmen, SS. Risk of seizure recurrence after the first late posttraumatic seizure. Arch Phys Med Rehabil 1997; 78: 835–40.CrossRefGoogle ScholarPubMed
Maas, AIR, Menon, DK, Adelson, PD, Andelic, N, Bell, MJ, Belli, A, et al. Traumatic brain injury: integrated approaches to improve prevention, clinical care, and research. Lancet Neurol 2017; 16: 9871048.Google Scholar
Hauser, WA, Annegers, JF, Kurland, LT. Incidence of epilepsy and unprovoked seizures in Rochester, Minnesota: 1935–1984. Epilepsia 1993; 34: 453–68.Google Scholar
WHO. Epilepsy: a public health imperative: summary. World Health Organization, 2019.Google Scholar
Kotsopoulos, IAW, van Merode, T, Kessels, FGH, de Krom, MCTF, Knottnerus, JA. Systematic review and meta-analysis of incidence studies of epilepsy and unprovoked seizures. Epilepsia 2002; 43: 1402–9.Google Scholar
Hesdorffer, DC, Logroscino, G, Benn, EKT, Katri, N, Cascino, G, Hauser, WA. Estimating risk for developing epilepsy. Neurology 2011; 76: 23–7.Google Scholar
Beghi, E, Carpio, A, Forsgren, L, Hesdorffer, DC, Malmgren, K, Sander, JW, et al. Recommendation for a definition of acute symptomatic seizure. Epilepsia 2010; 51: 671–5.CrossRefGoogle ScholarPubMed
Fisher, RS, Acevedo, C, Arzimanoglou, A, Bogacz, A, Cross, JH, Elger, CE, et al. ILAE Official Report: A practical clinical definition of epilepsy. Epilepsia 2014; 55: 475–82.CrossRefGoogle ScholarPubMed
Hauser, WA, Rich, SS, Lee, JR, Annegers, JF, Anderson, VE. Risk of recurrent seizures after two unprovoked seizures. N Engl J Med 1998; 338: 429–34.CrossRefGoogle ScholarPubMed
van Diessen, E, Lamberink, HJ, Otte, WM, Doornebal, N, Brouwer, OF, Jansen, FE, et al. A prediction model to determine childhood epilepsy after 1 or more paroxysmal events. Pediatrics 2018; 142:e20180931.Google Scholar
Ferguson, PL, Smith, GM, Wannamaker, BB, Thurman, DJ, Pickelsimer, EE, Selassie, AW. A population-based study of risk of epilepsy after hospitalization for traumatic brain injury. Epilepsia 2010; 51: 891–8.Google Scholar
Christensen, J, Pedersen, MG, Pedersen, CB, Sidenius, P, Olsen, J, Vestergaard, M. Long-term risk of epilepsy after traumatic brain injury in children and young adults: a population-based cohort study. Lancet 2009; 373: 1105–10.Google Scholar
Fisher, RS, Boas, WvE, Blume, W, Elger, C, Genton, P, Lee, P, et al. Epileptic seizures and epilepsy: Definitions Proposed by the International League Against Epilepsy (ILAE) and the International Bureau for Epilepsy (IBE). Epilepsia 2005; 46: 470–2.Google Scholar
Berg, AT. Risk of recurrence after a first unprovoked seizure. Epilepsia 2008; 49 Suppl 1: 13–8.Google Scholar
Hesdorffer, DC, Benn, EK, Cascino, GD, Hauser, WA. Is a first acute symptomatic seizure epilepsy? Mortality and risk for recurrent seizure. Epilepsia 2009.Google Scholar
Fisher, RS, Cross, JH, French, JA, Higurashi, N, Hirsch, E, Jansen, FE, et al. Operational classification of seizure types by the International League Against Epilepsy: Position Paper of the ILAE Commission for Classification and Terminology. Epilepsia 2017; 58: 522–30.Google Scholar
Scheffer, IE, Berkovic, S, Capovilla, G, Connolly, MB, French, J, Guilhoto, L, et al. ILAE classification of the epilepsies: Position paper of the ILAE Commission for Classification and Terminology. Epilepsia 2017; 58: 512–21.CrossRefGoogle ScholarPubMed
Salazar, AM, Jabbari, B, Vance, SC, Grafman, J, Amin, D, Dillon, JD. Epilepsy after penetrating head injury. I. Clinical correlates: a report of the Vietnam Head Injury Study. Neurology 1985; 35: 1406–14.Google Scholar
Williams, DH, Levin, HS, Eisenberg, HM. Mild head injury classification. Neurosurgery 1990; 27: 422–8.Google Scholar
Malec, JF, Brown, AW, Leibson, CL, Flaada, JT, Mandrekar, JN, Diehl, NN, et al. The mayo classification system for traumatic brain injury severity. J Neurotrauma 2007; 24: 1417–24.CrossRefGoogle ScholarPubMed
Rimel, RW, Giordani, B, Barth, JT, Jane, JA. Moderate head injury: completing the clinical spectrum of brain trauma. Neurosurgery 1982; 11: 344–51.Google Scholar
Association for the Advancement of Automotive Medicine, Committee on Injury Scaling. The Abbreviated Injury Scale, 1990 revision (AIS-90). Association for the Advancement of Automotive Medicine, Des Plaines, IL.Google Scholar
Foreman, BP, Caesar, RR, Parks, J, Madden, C, Gentilello, LM, Shafi, S, et al. Usefulness of the abbreviated injury score and the injury severity score in comparison to the Glasgow Coma Scale in predicting outcome after traumatic brain injury. J Trauma 2007; 62: 946–50.Google Scholar
Demetriades, D, Kuncir, E, Murray, J, Velmahos, GC, Rhee, P, Chan, L. Mortality prediction of head Abbreviated Injury Score and Glasgow Coma Scale: analysis of 7,764 head injuries. Journal of the American College of Surgeons 2004; 199: 216–22.Google Scholar
Walder, AD, Yeoman, PM, Turnbull, A. The abbreviated injury scale as a predictor of outcome of severe head injury. Intensive Care Med 1995; 21: 606–9.Google Scholar
Mahler, B, Carlsson, S, Andersson, T, Adelow, C, Ahlbom, A, Tomson, T. Unprovoked seizures after traumatic brain injury: A population-based case-control study. Epilepsia 2015; 56: 1438–44.Google Scholar
Yeh, CC, Chen, TL, Hu, CJ, Chiu, WT, Liao, CC. Risk of epilepsy after traumatic brain injury: a retrospective population-based cohort study. J Neurol Neurosurg Psychiatry 2013; 84: 441–5.Google Scholar
Sharp, DJ, Jenkins, PO. Concussion is confusing us all. Pract Neurol 2015; 15: 172–86.Google Scholar
Frey, LC. Epidemiology of posttraumatic epilepsy: A critical review. Epilepsia 2003; 44: 11–7.Google Scholar
Forsgren, L, Beghi, E, Oun, A, Sillanpaa, M. The epidemiology of epilepsy in Europe – a systematic review. Eur J Neurol 2005; 12: 245–53.Google Scholar
Zhao, Y, Wu, H, Wang, X, Li, J, Zhang, S. Clinical epidemiology of posttraumatic epilepsy in a group of Chinese patients. Seizure 2012; 21:322–6.Google Scholar

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