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Chapter 1 - Neurobiological Aspects of Post-traumatic Epilepsy: Lessons from Animal Models

Published online by Cambridge University Press:  10 August 2021

By
Patricia G. Saletti ,
Anna Maria Katsarou ,
Mariana Molero  and
Aristea S. Galanopoulou
Edited by
Marco Mula
Marco Mula
Affiliation:
St George's Hospital Medical School, University of London
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Summary

Traumatic brain injury (TBI) is a leading type of epilepsy with significant repercussions for the quality of life of patients, due to the associated injury, consequent epilepsy and cognitive, behavioral or neuropsychiatric sequelae. There have been intense efforts to generate better strategies and methods to treat these patients better. This chapter reviews the advances in animal models of posttraumatic epilepsy (PTE), focusing on rodents, presenting an update on models, their phenotype, findings on neurobiology of TBI and PTE and future directions. The value of models, like the fluid percussion injury, controlled cortical impact, blast, penetrating TBI, weight drop TBI, in this process in being discussed as well as efforts to accelerate progress in the field through the use of collaborative research and infrastructure.

Keywords

rodentmodel of traumatic brain injurymodel of posttraumatic epilepsyfluid percussion injurycontrolled cortical impactpenetrating injuryblast injurytauinflammationhemorrhagetreatmentcomorbidities
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Chapter
Information
Post-traumatic Epilepsy , pp. 1 - 28
Publisher: Cambridge University Press
Print publication year: 2021

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