Skip to main content Accessibility help

We use cookies to distinguish you from other users and to provide you with a better experience on our websites. Close this message to accept cookies or find out how to manage your cookie settings.

Close cookie message
×
Hostname: page-component-78c5997874-j824f Total loading time: 0 Render date: 2024-11-05T06:43:42.876Z Has data issue: false hasContentIssue false

Chapter 15 - The Role of In Vitro Maturation in Polycystic Ovary Syndrome

Published online by Cambridge University Press:  13 May 2022

By
Roger J. Hart  and
Melanie Walls
Edited by
Gabor T. Kovacs ,
Bart Fauser  and
Richard S. Legro
Gabor T. Kovacs
Affiliation:
Monash University, Melbourne, Australia
Bart Fauser
Affiliation:
University Medical Center, Utrecht, Netherlands
Richard S. Legro
Affiliation:
Penn State Medical Center, Hershey, PA, USA
Get access

Summary

In vitro maturation of oocytes (IVM) describes a process whereby immature oocytes that have been collected as part of an assisted reproductive treatment cycle are matured in a laboratory. After maturation, they are usually fertilized with sperm, via intracytoplasmic sperm injection (ICSI), and the resulting embryos cultured. The perceived benefits of this technology are that it involves a shorter duration of time between the commencement of a treatment cycle and oocyte collection, and it avoids the risk of ovarian hyperstimulation syndrome (OHSS). OHSS is a very serious medical condition that women with polycystic ovary syndrome (PCOS) are particularly susceptible to developing. IVM technology has been used for several decades, but in the last ten years there has been a resurgence of interest in its use with the development of enhanced maturation media to assist the IVM process and the initiation of several randomized trials to compare potential benefits and drawbacks in comparison to the standard in vitro fertilization (IVF) approach.

Keywords

In vitro maturation (IVM)polycystic ovary syndrome (PCOS)in vitro fertilization (IVF)ovarian hyperstimulation syndrome (OHSS)
Type
Chapter
Information
Polycystic Ovary Syndrome , pp. 142 - 149
Publisher: Cambridge University Press
Print publication year: 2022

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Pincus, G. and Enzmann, E. V. The comparative behavior of mammalian eggs in vivo and in vitro. J Exp Med 1935; 62(5): 665–675.CrossRefGoogle ScholarPubMed
Edwards, R. G. Maturation in vitro of mouse, sheep, cow, pig, rhesus monkey and human ovarian oocytes. Nature 1965; 208(5008): 349–351.Google Scholar
Cha, K. Y., Koo, J. J., Ko, J. J., Choi, D. H., Han, S. Y. and Yoon, T. K. Pregnancy after in vitro fertilization of human follicular oocytes collected from nonstimulated cycles, their culture in vitro and their transfer in a donor oocyte program. Fertil Steril 1991; 55(1): 109.CrossRefGoogle Scholar
Trounson, A., Wood, C. and Kausche, A. In vitro maturation and the fertilization and developmental competence of oocytes recovered from untreated polycystic ovarian patients. Fertil Steril 1994; 62(2): 353.CrossRefGoogle ScholarPubMed
Junk, S. M. and Yeap, D. Improved implantation and ongoing pregnancy rates after single-embryo transfer with an optimized protocol for in vitro oocyte maturation in women with polycystic ovaries and polycystic ovary syndrome. Fertil Steril 2012; 98(4): 888–892.Google Scholar
Eppig, J. J. Coordination of nuclear and cytoplasmic oocyte maturation in eutherian mammals. Reprod Fertil Dev 1996; 8(4): 485–489.Google Scholar
Ben-Ami, I., Komsky, A., Bern, O., Kasterstein, E., Komarovsky, D. and Ron-El, R. In vitro maturation of human germinal vesicle-stage oocytes: Role of epidermal growth factor-like growth factors in the culture medium. Hum Reprod 2011; 26(1): 76–81.Google Scholar
Hreinsson, J., Rosenlund, B., Fridén, B. et al. Recombinant LH is equally effective as recombinant hCG in promoting oocyte maturation in a clinical in‐vitro maturation programme: a randomized study. Hum Reprod 2003; 18(10): 2131–2136.CrossRefGoogle Scholar
Child, T. J., Abdul-Jalil, A. K., Gulekli, B. and Lin Tan, S. In vitro maturation and fertilization of oocytes from unstimulated normal ovaries, polycystic ovaries, and women with polycystic ovary syndrome. Fertil Steril 2001; 76(5): 936–942.CrossRefGoogle ScholarPubMed
Walls, M., Junk, S., Ryan, J. and Hart, R. IVF versus ICSI for the fertilization of in-vitro matured human oocytes. Reprod Biomed Online 2012; 25(6): 603–607.Google Scholar
Tang, H., Hunter, T., Hu, Y., Zhai, S. D., Sheng, X. and Hart, R. J. Cabergoline for preventing ovarian hyperstimulation syndrome. Cochrane Database Syst Rev. 2012; 2: CD008605.Google Scholar
Walls, M. L., Hunter, T., Ryan, J. P., Keelan, J. A., Nathan, E. and Hart, R. J. In vitro maturation as an alternative to standard in vitro fertilization for patients diagnosed with polycystic ovaries: A comparative analysis of fresh, frozen and cumulative cycle outcomes. Hum Reprod 2015; 30(1): 88–96.CrossRefGoogle ScholarPubMed
Walls, M. L., Ryan, J. P., Keelan, J. A. and Hart, R. In vitro maturation is associated with increased early embryo arrest without impairing morphokinetic development of useable embryos progressing to blastocysts. Hum Reprod 2015; 30(8): 1842–1849.Google Scholar
Chian, R. C., Buckett, W. M., Too, L. L. and Tan, S. L. Pregnancies resulting from in vitro matured oocytes retrieved from patients with polycystic ovary syndrome after priming with human chorionic gonadotropin. Fertil Steril 1999; 72(4): 639–642.CrossRefGoogle ScholarPubMed
Radesic, B. and Tremellen, K. Oocyte maturation employing a GnRH agonist in combination with low-dose hCG luteal rescue minimizes the severity of ovarian hyperstimulation syndrome while maintaining excellent pregnancy rates. Hum Reprod 2011; 26(12): 3437–3442.CrossRefGoogle ScholarPubMed
Boothroyd, C., Karia, S., Andreadis, N. et al. Consensus statement on prevention and detection of ovarian hyperstimulation syndrome. Aust N Z J Obstet Gynaecol 2015; 55(6): 523–534.CrossRefGoogle ScholarPubMed
Walls, M. L., Douglas, K., Ryan, J. P., Tan, J. and Hart, R. In-vitro maturation and cryopreservation of oocytes at the time of oophorectomy. Gynecol Oncol Rep 2015; 13: 79–81.CrossRefGoogle ScholarPubMed
Dahan, M. H., Tan, S. L., Chung, J. and Son, W. Y. Clinical definition paper on in vitro maturation of human oocytes. Hum Reprod 2016; 31(7): 1383–1386.Google Scholar
Mikkelsen, A. L., Smith, S. D. and Lindenberg, S. In-vitro maturation of human oocytes from regularly menstruating women may be successful without follicle stimulating hormone priming. Hum Reprod 1999; 14(7): 1847–1851.Google Scholar
Mikkelsen, A. and Lindenberg, S. Benefit of FSH priming of women with PCOS to the in vitro maturation procedure and the outcome: A randomized prospective study. Reproduction 2001; 122(4): 587–92.CrossRefGoogle Scholar
Zheng, X., Wang, L., Zhen, X., Lian, Y., Liu, P. and Qiao, J. Effect of hCG priming on embryonic development of immature oocytes collected from unstimulated women with polycystic ovarian syndrome. Reprod Biol Endocrinol 2012; 10: 40.Google Scholar
Lin, Y., Zheng, X., Ma, C. et al. Human chorionic gonadotropin priming does not improve pregnancy outcomes of PCOS-IVM cycles. Front Endocrinol 2020; 11: 279.Google Scholar
Reavey, J., Vincent, K., Child, T. and Granne, I. E. Human chorionic gonadotrophin priming for fertility treatment with in vitro maturation. Cochrane Database Syst Rev. 2016; 11: CD008720.Google Scholar
Yoon, H.-G., Yoon, S.-H., Son, W.-Y. et al. Clinical assisted reproduction: Pregnancies resulting from in vitro matured oocytes collected from women with regular menstrual cycle. J Assist Reprod Genet 2001;18(6):325–329.Google Scholar
Rose, B. I. and Laky, D. A comparison of the Cook single lumen immature ovum IVM needle to the Steiner-Tan pseudo double lumen flushing needle for oocyte retrieval for IVM. J Assist Reprod Genet 2013; 30(6): 855–860.CrossRefGoogle Scholar
Sasseville, M., Gagnon, M. C., Guillemette, C., Sullivan, R., Gilchrist, R. B. and Richard, F. J. Regulation of gap junctions in porcine cumulus-oocyte complexes: Contributions of granulosa cell contact, gonadotropins, and lipid rafts. Mol Endocrinol 2009; 23(5): 700–710.CrossRefGoogle ScholarPubMed
Pongsuthirak, P. and Vutyavanich, T. Comparison of Medicult and Sage media for in vitro maturation of immature oocytes obtained during cesarean deliveries. JFIV Reprod Med Genet 2015; 3: 136.Google Scholar
Pongsuthirak, P., Songveeratham, S. and Vutyavanich, T. Comparison of blastocyst and Sage media for in vitro maturation of human immature oocytes. Reprod Sci 2015; 22(3): 343–346.CrossRefGoogle ScholarPubMed
Mikkelsen, A. L., Smith, S. and Lindenberg, S. Impact of oestradiol and inhibin A concentrations on pregnancy rate in in-vitro oocyte maturation. Hum Reprod 2000; 15(8): 1685–1690.Google Scholar
Söderström-Anttila, V., Mäkinen, S., Tuuri, T. and Suikkari, A.-M. Favourable pregnancy results with insemination of in vitro matured oocytes from unstimulated patients. Hum Reprod 2005; 20(6): 1534–1540.CrossRefGoogle ScholarPubMed
Le Du, A., Kadoch, I. J., Bourcigaux, N. et al. In vitro oocyte maturation for the treatment of infertility associated with polycystic ovarian syndrome: The French experience. Hum Reprod 2005; 20(2): 420–424.CrossRefGoogle ScholarPubMed
Pongsuthirak, P. The effect of insemination methods on in vitro maturation outcomes. Clin Exp Reprod Med 2020; 47(2): 130–134.CrossRefGoogle ScholarPubMed
Yu, E. J., Yoon, T. K., Lee, W. S. et al. Obstetrical, neonatal, and long-term outcomes of children conceived from in vitro matured oocytes. Fertil Steril 2019; 112(4): 691–699.CrossRefGoogle ScholarPubMed
Belva, F., Roelants, M., Vermaning, S. et al. Growth and other health outcomes of 2-year-old singletons born after IVM versus controlled ovarian stimulation in mothers with polycystic ovary syndrome. Hum Reprod Open 2020; 1: hoz043.Google Scholar
Saenz-de-Juano, M. D., Ivanova, E., Romero, S. et al. DNA methylation and mRNA expression of imprinted genes in blastocysts derived from an improved in vitro maturation method for oocytes from small antral follicles in polycystic ovary syndrome patients. Hum Reprod 2019; 34(9): 1640–1649.CrossRefGoogle ScholarPubMed
Mottershead, D. G., Sugimura, S., Al-Musawi, S. L. et al. Cumulin, an oocyte-secreted heterodimer of the transforming growth factor-beta family, is a potent activator of granulosa cells and improves oocyte quality. J Biol Chem 2015; 290(39): 24007–24020.Google Scholar
Spits, C., Guzman, L., Mertzanidou, A. et al. Chromosome constitution of human embryos generated after in vitro maturation including 3-isobutyl-1-methylxanthine in the oocyte collection medium. Hum Reprod 2015; 30(3): 653–663.CrossRefGoogle ScholarPubMed
Sanchez, F., Lolicato, F., Romero, S. et al. An improved IVM method for cumulus-oocyte complexes from small follicles in polycystic ovary syndrome patients enhances oocyte competence and embryo yield. Hum Reprod 2017; 32(10): 2056–2068.Google Scholar
Ma, L., Cai, L., Hu, M. et al. Coenzyme Q10 supplementation of human oocyte in vitro maturation reduces postmeiotic aneuploidies. Fertil Steril 2020; 114(2): 331–337.CrossRefGoogle ScholarPubMed
Zheng, X., Guo, W., Zeng, L. et al. Live birth after in vitro maturation versus standard in vitro fertilisation for women with polycystic ovary syndrome: Protocol for a non-inferiority randomised clinical trial. BMJ Open 2020; 10(4): e035334.CrossRefGoogle ScholarPubMed
Vuong, L. N., Ho, V. N. A., Ho, T. M. et al. Effectiveness and safety of in vitro maturation of oocytes versus in vitro fertilisation in women with high antral follicle count: Study protocol for a randomised controlled trial. BMJ Open 2018; 8(12): e023413.CrossRefGoogle ScholarPubMed

Save book to Kindle

To save this book to your Kindle, first ensure [email protected] is added to your Approved Personal Document E-mail List under your Personal Document Settings on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part of your Kindle email address below. Find out more about saving to your Kindle.

Note you can select to save to either the @free.kindle.com or @kindle.com variations. ‘@free.kindle.com’ emails are free but can only be saved to your device when it is connected to wi-fi. ‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.

Find out more about the Kindle Personal Document Service.

Available formats
×

Save book to Dropbox

To save content items to your account, please confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account. Find out more about saving content to Dropbox.

Available formats
×

Save book to Google Drive

To save content items to your account, please confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account. Find out more about saving content to Google Drive.

Available formats
×