Polycystic ovary syndrome (PCOS) is a common and complex endocrine condition. Its heterogeneous expression creates diagnostic, treatment and management challenges for both health professionals and affected women. In girls with PCOS, the weight-gain trajectory deviates in early adolescence, creating momentum toward early onset metabolic disease. Excess weight in women with PCOS starts at an earlier age, increases at a greater rate and is commonly centrally located when compared to women without PCOS. Women with PCOS are also at higher risk of reproductive disorders such as infertility. In addition, an interplay of physiological and social factors place affected women at a greater risk of a range of emotional challenges. Despite the significant health burden of PCOS, women report delayed diagnosis and unsatisfactory information and support provision. In particular, they report difficulties in accessing clear guidance and ongoing support on necessary lifestyle changes.