This essay considers religion in Pirandello’s oeuvre from a historical point of view, that is to say, as firmly anchored in a post-Copernican modernity in which, as philosopher Friedrich Nietzsche famously proclaimed, “God is dead,” and relativity came to be understood as scientific fact in the wake of Albert Einstein’s investigations. The essay asks whether a consistent meditation on religion can be found in Pirandello’s oeuvre and therefore considers several works, among them, The Late Mattia Pascal; Shoot!; Lazarus; and One, No One, and One Hundred Thousand. Particular focus is given to the ways in which these writings demonstrate Pirandello’s interest in mysticism, a non-dogmatic Catholic Modernism, and his rejection of any transcendent God, a belief which corresponded to his humoristic view of life more generally, tied as they both were to his uneasiness over life’s lack of certainty.