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  1. Home
  2. Books
  3. Pharmacogenetics of Psychotropic Drugs
  • Cited by 15
  • Edited by Bernard Lerer, Hadassah-Hebrew Medical Center, Jerusalem
Publisher:
Cambridge University Press
Online publication date:
August 2009
Print publication year:
2002
Online ISBN:
9780511543944
DOI:
https://doi.org/10.1017/CBO9780511543944
Subjects:
Psychiatry and Clinical Psychology, Neurology and Clinical Neuroscience, Medicine, Psychiatry
Information

Book description

Pharmacogenetics and pharmacogenomics are areas of significant importance at the interface of molecular genetics and psychopharmacology, with implications for drug development and clinical practice. This 2002 book provides a conceptual framework for understanding and studying the pharmacogenetics of psychotropic drugs, reviews advances in the field, and describes the established findings. Coverage extends to antipsychotics, antidepressants, mood stabilising, cognitive-enhancing and anxiolytic drugs. Chapters also examine the interface of pharmacogenetics with substance dependence and brain imaging, and consider its impact on the biotechnology and pharmaceutical industries. This book defines the young field of pharmacogenetics as it applies to psychotropic drugs, and is therefore of interest to all clinicians and researchers working in this field.

Reviews

Review of the hardback:‘… this is a well-written book on a subject which is often found complicated and difficult … the book will be informative for the reader who wants a general review of the field of psychopharmacogenetics, but will also be useful for the reader who wants updated information on a specific topic …’European Journal of Clinical Pharmacology

Review of the hardback:'This book gives a comprehensive review of the current state of the art covering almost all aspects of psychiatric pharmacogenetics. It provides an excellent introduction to the newcomer in this field and at the same time it is a most valuable source of information also for the experts.'Acta Psychiatrica Scandinavica

Review of the hardback:'Bernard Lerer is to be congratulated in bringing together a group of authors who have presented an excellent, yet concise, overview of the importance of pharmacogenetics in contemporary psychopharmacology. … this monograph is recommended to all those wishing to keep abreast of this important area of neuroscience.'Human Psychopharmacology

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Contents

Page 2 of 2

Contents
  • 21 - High-throughput single nucleotide polymorphism genotyping
    pp 422-440
    • By Anne Shalom, The Life Sciences Institute, The Hebrew University of Jerusalem, Israel, Ariel Darvasil, The Life Sciences Institute, The Hebrew University of Jerusalem, Israel; IDgene Pharmaceuticals Ltd, Jerusalem, Israel
  • View abstract

    Summary

    Maximizing drug response while minimizing adverse effects for individuals through the study of gene variations is the goal of pharmacogenomics. The most common type of human genetic variation is the Single nucleotide polymorphism (SNP), a position at which two alternative bases occur at appreciable frequency (>1%) in the human population. There are three major phases to SNP pharmacogenomics: SNP discovery and mapping, SNP scoring, and SNP diagnostics. Among these, the scoring step holds the greatest potential for uncovering medically important information. This step necessitates applying high-throughput SNP genotyping methods in the context of well-designed clinical pharmacogenetics correlation studies. This chapter presents the basic principle of the methods employed for SNP allele discrimination and detection. Most methods currently adopted require a preliminary amplification, by the polymerase chain reaction (PCR), of a small DNA fragment around the SNP to be analyzed.

Page 2 of 2

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