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6 - Postoperative Cognitive Issues

from Section 2 - General Health and Illness

Published online by Cambridge University Press:  06 January 2018

Sheila Ryan Barnett
Affiliation:
Harvard University Medical School, Massachusetts
Sara E. Neves
Affiliation:
Beth Israel Deaconess Medical Center, Boston, MA, USA
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Publisher: Cambridge University Press
Print publication year: 2018

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References

Fried, TR, Bradley, EH, Towle, VR, Allore, H. Understanding the treatment preferences of seriously ill patients. N Engl J Med. 2002; 346(14):10611066.CrossRefGoogle ScholarPubMed
Crosby, G, Culley, D. Preoperative cognitive assessment of the elderly surgical patient: a call for action. Anesthesiology. 2011; 114:12651268.CrossRefGoogle Scholar
American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition, 5th edn. Washington, DC, American Psychiatric Association, 2013.Google Scholar
Inouye, S, van Dyck, C, Alessi, C, et al. Clarifying confusion: the confusion assessment method. A new method for detection of delirium. Ann Intern Med. 1990; 113(12):941948.CrossRefGoogle Scholar
Breitbart, W, Rosenfeld, B, Roth, A, et al. The Memorial Delirium Assessment Scale. J Pain Symptom Manage. 1997; 13(3):128137.CrossRefGoogle ScholarPubMed
Wei, L, Fearing, M, Sternberg, E, Inouye, SK. The Confusion Assessment Method: a systematic review of current usage. J Am Geriatr Soc. 2008; 56:823830.CrossRefGoogle Scholar
Ely, EW, Margolin, R, Francis, J, et al. Evaluation of delirium in critically ill patients: validation of the Confusion Assessment Method for the Intensive Care Unit (CAM-ICU). Crit Care Med. 2001; 29(7):13701379.CrossRefGoogle ScholarPubMed
Inouye, SK, Foreman, MD, Mion, LC, et al. Nurses' recognition of delirium and its symptoms: comparison of nurse and researcher ratings. Arch Int Med. 2001; 161(20):24672473.CrossRefGoogle ScholarPubMed
Yang, FM, Marcantonio, ER, Inouye, SK, et al. Phenomenological subtypes of delirium in older persons: patterns, prevalence, and prognosis. Psychosomatics. 2009; 50(3):248254.CrossRefGoogle ScholarPubMed
Stransky, M, Schmidt, C, Ganslmeier, P, et al. Hypoactive delirium after cardiac surgery as an independent risk factor for prolonged mechanical ventilation. J Cardiothor Vasc Anesth. 2011; 25:968974.CrossRefGoogle Scholar
Trzepacz, P, Mittal, D, Torres, R. Validation of the Delirium Rating Scale-Revised-98: comparison with the Delirium Rating Scale and the Cognitive Test for Delirium. J Neuropsychiatry Clin Neurosci. 2001; 13(2):229242.CrossRefGoogle ScholarPubMed
Inouye, SK, Kosar, CM, Tommet, D, et al. The CAM-S: development and validation of a new scoring system for delirium severity in 2 cohorts. Ann Intern Med. 2014; 160(8):526533.CrossRefGoogle ScholarPubMed
Cole, MM, McCusker, JJ, Dendukuri, NN, Han, LL. The prognostic significance of subsyndromal delirium in elderly medical inpatients. J Am Geriatr Soc. 2003; 51(6):754760.CrossRefGoogle ScholarPubMed
Inouye, SK, Leo-Summers, L, Zhang, Y, et al. A chart-based method for identification of delirium: validation compared with interviewer ratings using the Confusion Assessment Method. J Am Geriatr Soc. 2005; 53(2):312318.CrossRefGoogle ScholarPubMed
Koster, S, Hensens, AG, Schuurmans, MJ, van der Palen, J. Consequences of delirium after cardiac operations. Ann Thorac Surg. 2012; 93(3):705711.CrossRefGoogle ScholarPubMed
Rudolph, JL, Jones, RN, Levkoff, SE, et al. Derivation and validation of a preoperative prediction rule for delirium after cardiac surgery. Circulation. 2009; 119(2):229236.CrossRefGoogle ScholarPubMed
Kalisvaart, K, Vreeswijk, R. Risk factors and prediction of postoperative delirium in elderly hip-surgery patients: implementation and validation of a medical risk factor model. J Am Geriatr Soc. 2006; 54:817822.CrossRefGoogle ScholarPubMed
Bickel, H, Gradinger, R, Kochs, E, Forstl, H. High risk of cognitive and functional decline after postoperative delirium. Dement Geriatr Cogn Disord. 2008; 26:2631.CrossRefGoogle ScholarPubMed
Sieber, F, Zakriya, K, Gottschalk, A, et al. Sedation depth during spinal anesthesia and the development of postoperative delirium in elderly patients undergoing hip fracture repair. Mayo Clin Proc. 2010; 85:1826.CrossRefGoogle ScholarPubMed
Benoit, AG, Campbell, BI, Tanner, JR, et al. Risk factors and prevalence of perioperative cognitive dysfunction in abdominal aneurysm patients. J Vasc Surg. 2005; 42(5):884890.CrossRefGoogle ScholarPubMed
Ansaloni, L, Catena, F, Chattat, R, et al. Risk factors and incidence of postoperative delirium in elderly patients after elective and emergency surgery. Br J Surg. 2010; 97:273280.CrossRefGoogle ScholarPubMed
Brown, CH IV, Dowdy, D. Risk factors for delirium: are systematic reviews enough? Crit Care Med. 2015; 43(1):232233.CrossRefGoogle Scholar
Albrecht, JS, Marcantonio, ER, Roffey, DM, et al. Stability of postoperative delirium psychomotor subtypes in individuals with hip fracture. J Am Geriatr Soc. 2015; 63:970976.CrossRefGoogle ScholarPubMed
Inouye, S, Westendorp, R, Sazynski, J. Delirium in elderly people. Lancet. 2014; 383:911922.CrossRefGoogle ScholarPubMed
Marcantonio, ER, Goldman, L, Mangione, CM, et al. A clinical prediction rule for delirium after elective noncardiac surgery. JAMA. 1994; 271(2):134139.CrossRefGoogle ScholarPubMed
Leung, JM, Tsai, TL, Sands, LP. Preoperative frailty in older surgical patients is associated with early postoperative delirium. Anesth Analg. 2011; 112(5):11991201.CrossRefGoogle ScholarPubMed
Jung, P, Pereira, M, Hiebert, B, et al. The impact of frailty on postoperative delirium in cardiac surgery patients. J Thorac Cardiovasc Surg. 2015; 149:869875.CrossRefGoogle ScholarPubMed
Hshieh, TT, Fong, TG, Marcantonio, ER, Inouye, SK. Cholinergic deficiency hypothesis in delirium: a synthesis of current evidence. J Gerontol A Biol Sci Med Sci. 2008; 63(7):764772.CrossRefGoogle ScholarPubMed
Dantzer, R, O'Connor, JC, Freund, GG, Johnson, RW, Kelley, KW. From inflammation to sickness and depression: when the immune system subjugates the brain. Nat Rev Neurosci. 2008; 9(1):4656.CrossRefGoogle Scholar
van Munster, BC, Aronica, E, Zwinderman, AH, et al. Neuroinflammation in delirium: a postmortem case-control study. Rejuv Res. 2011; 14(6):615622.CrossRefGoogle Scholar
Fong, TG, Bogardus, ST, Daftary, A, et al. Cerebral perfusion changes in older delirious patients using 99mTc HMPAO SPECT. J Gerontol A Biol Sci Med Sci. 2006; 61(12):12941299.CrossRefGoogle ScholarPubMed
Hori, D, Brown, C, Ono, M, et al. Arterial pressure above the upper cerebral autoregulation limit during cardiopulmonary bypass is associated with postoperative delirium. Br J Anaesth. 2014; 113(6):10091017.CrossRefGoogle ScholarPubMed
Acharya, NK, Goldwaser, EL, Forsberg, MM, et al. Sevoflurane and isoflurane induce structural changes in brain vascular endothelial cells and increase blood–brain barrier permeability: possible link to postoperative delirium and cognitive decline. Brain Res. 2015; 1620:2941.CrossRefGoogle ScholarPubMed
Gottesman, R, Grega, M, Bailey, M, et al. Delirium after coronary artery bypass graft surgery and late mortality. Ann Neurol. 2010; 67:338344.CrossRefGoogle ScholarPubMed
Ely, EW, Shintani, A, Truman, B, et al. Delirium as a predictor of mortality in mechanically ventilated patients in the intensive care unit. JAMA. 2004; 291(14):17531762.CrossRefGoogle ScholarPubMed
Pisani, MA, Kong, SY, Kasl, SV, et al. Days of delirium are associated with 1-year mortality in an older intensive care unit population. Am J Respir Crit Care Med. 2009; 180:10921097.CrossRefGoogle Scholar
Martin, B, Buth, K, Arora, R, Baskett, R. Delirium as a predictor of sepsis in postcoronary artery bypass grafting patients: a retrospective cohort study. Crit Care. 2010; 14:R171.CrossRefGoogle ScholarPubMed
House, A, Holmes, J. Occurrence and outcome of delirium in medical in-patients: a systematic literature review. Age Ageing. 2006; 35:350364.Google Scholar
Saczynski, JS, Marcantonio, ER, Quach, L, et al. Cognitive trajectories after postoperative delirium. N Engl J Med. 2012; 367(1):3039.CrossRefGoogle ScholarPubMed
MacLullich, AM, Beaglehole, A, Hall, RJ, Meagher, DJ. Delirium and long-term cognitive impairment. Int Rev Psychiatry. 2009; 21(1):3042.CrossRefGoogle ScholarPubMed
Gottschalk, A, Hubbs, J, Vikani, AR, Gottschalk, LB, Sieber, FE. The impact of incident postoperative delirium on survival of elderly patients after surgery for hip fracture repair. Anesth Analg. 2015; 121(5):13361343.CrossRefGoogle ScholarPubMed
Sieber, F, Barnett, S. Preventing postoperative complications in the elderly. Anesthesiol Clin. 2011; 29:8397.CrossRefGoogle ScholarPubMed
American Geriatrics Society Expert Panel on Postoperative Delirium in Older Adults. American Geriatrics Society abstracted clinical practice guideline for postoperative delirium in older adults. J Am Geriatr Soc. 2015; 63:142150.Google Scholar
Barr, J, Fraser, GL, Puntillo, K, et al. Clinical practice guidelines for the management of pain, agitation, and delirium in adult patients in the intensive care unit. Crit Care Med. 2013; 41(1):263306.CrossRefGoogle ScholarPubMed
Young, J, Murthy, L, Westby, M, et al. Diagnosis, prevention, and management of delirium: summary of NICE guidance. BMJ. 2010; 341:c3704.CrossRefGoogle ScholarPubMed
Inouye, S, Bogardus, S, Charpentier, P, et al. A multicomponent intervention to prevent delirium in hospitalized older patients. NEJM. 1999; 340:669676.CrossRefGoogle ScholarPubMed
Lundström, M, Olofsson, B, Stenvall, M, et al. Postoperative delirium in old patients with femoral neck fracture: a randomized intervention study. Aging Clin Exp Res. 2007; 19(3):178186.CrossRefGoogle ScholarPubMed
Chen, C, Lin, MT, Tien, YW, et al. Modified Hospital Elder Life Program: effects on abdominal surgery patients. J Am Coll Surg. 2011; 213(2):245252.CrossRefGoogle ScholarPubMed
Marcantonio, E, Flacker, J, Wright, R, Resnick, N. Reducing delirium after hip fracture: a randomized trial. J Am Geriatr Soc. 2001; 49:516522.CrossRefGoogle ScholarPubMed
Lynch, E, Lazor, M, Gellis, J, et al. The impact of postoperative pain on the development of postoperative delirium. Anesth Analg. 1998; 86:781785.Google ScholarPubMed
Vaurio, LE, Sands, LP, Wang, Y, Mullen, EA, Leung, JM. Postoperative delirium: the importance of pain and pain management. Anesth Analg. 2006; 102(4):12671273.CrossRefGoogle ScholarPubMed
Krenk, L, Rasmussen, LS, Hansen, TB, et al. Delirium after fast-track hip and knee arthroplasty. Br J Anaesth. 2012; 108:607611.CrossRefGoogle ScholarPubMed
Leung, JM, Sands, LP, Rico, M, et al. Pilot clinical trial of gabapentin to decrease postoperative delirium in older patients. Neurology. 2006; 67(7):12511253.CrossRefGoogle ScholarPubMed
Kinjo, S, Lim, E, Sands, LP, Bozic, KJ, Leung, JM. Does using a femoral nerve block for total knee replacement decrease postoperative delirium? BMC Anesthesiol. 2012; 12(1):4.CrossRefGoogle ScholarPubMed
Mouzopoulos, G, Vasiliadis, G, Lasanianos, N, et al. Fascia iliaca block prophylaxis for hip fracture patients at risk for delirium: a randomized placebo-controlled study. J Orthopaed Traumatol. 2009; 10(3):127133.CrossRefGoogle ScholarPubMed
Marcantonio, ER, Juarez, G, Goldman, L, et al. The relationship of postoperative delirium with psychoactive medications. JAMA. 1994; 272(19):15181522.CrossRefGoogle ScholarPubMed
Fong, HK, Sands, LP, Leung, JM. The role of postoperative analgesia in delirium and cognitive decline in elderly patients: a systematic review. Anesth Analg. 2006; 102(4):12551266.CrossRefGoogle ScholarPubMed
Riker, R, Shehabi, Y, Bokesch, P, et al. Dexmedetomidine vs midazolam for sedation of critically ill patients. JAMA. 2009; 301:489499.CrossRefGoogle ScholarPubMed
Pandharipande, P, Pun, B, Herr, D, et al. Effect of sedation with dexmedetomidine vs lorazepam on acute brain dysfunction in mechanically ventilated patients: the MENDS randomized controlled trial. JAMA. 2007; 298(22):26442653.CrossRefGoogle Scholar
Maldonado, JR, Wysong, A, van der Starre, P, et al. Dexmedetomidine and the reduction of postoperative delirium after cardiac surgery. Psychosomatics. 2009; 50(3):206217.CrossRefGoogle ScholarPubMed
Hogan, D. Revisiting the O complex: urinary incontinence, delirium and polypharmacy in elderly patients. Can Med Assoc J. 1997; 157:10711077.Google Scholar
The American Geriatrics Society 2012 Beers Criteria Update Expert Panel. American Geriatrics Society Updated Beers Criteria for Potentially Inappropriate Medication Use in Older Adults. J Am Geriatr Soc. 2012; 60(4):616631.CrossRefGoogle Scholar
Hakim, S, Othman, A, Naoum, D. Early treatment with risperidone for subsyndromal delirium after on-pump cardiac surgery in the elderly. Anesthesiology. 2012; 116:987997.CrossRefGoogle ScholarPubMed
Kalisvaart, K, De Jonghe, J, Bogaards, M. Haloperidol prophylaxis for elderly hip-surgery patients at risk for delirium: a randomized placebo-controlled study. J Am Geriatr Soc. 2005; 53:16581666.CrossRefGoogle ScholarPubMed
Sauër, A-MC, Slooter, A, Veldhuijzen, D, et al. Intraoperative dexamethasone and delirium after cardiac surgery. Anesth Analg. 2014; 119(5):10461052.CrossRefGoogle ScholarPubMed
Gamberini, M, Bolliger, D, Lurati Buse, GA, et al. Rivastigmine for the prevention of postoperative delirium in elderly patients undergoing elective cardiac surgery: a randomized controlled trial. Crit Care Med. 2009; 37(5):17621768.CrossRefGoogle ScholarPubMed
van Eijk, MD, Roes, K, Honing, M, et al. Effect of rivastigmine as an adjunct to usual care with haloperidol on duration of delirium and mortality in critically ill patients: a multicentre, double-blind, placebo-controlled randomised trial. Lancet. 2010; 376(9755):18291837.CrossRefGoogle Scholar
Fava, M. Prospective studies of adverse events related to antidepressant discontinuation. J Clin Psychiatry. 2006; 67(Suppl 4):1421.Google ScholarPubMed
Xie, Z, Dong, Y, Maeda, U, Alfille, P, Culley, DJ. The common inhalation anesthetic isoflurane induces apoptosis and increases amyloid β protein levels. Anesthesiology. 2006; 104:988994.CrossRefGoogle ScholarPubMed
Zhang, B, Dong, Y, Zhang, G, et al. The inhalation anesthetic desflurane induces caspase activation and increases amyloid β-protein levels under hypoxic conditions. J Biol Chem. 2008; 283(18):1186611875.CrossRefGoogle ScholarPubMed
Zhang, Y, Dong, Y, Wu, X, et al. The mitochondrial pathway of anesthetic isoflurane-induced apoptosis. J Biol Chem. 2010; 285:40254037.CrossRefGoogle ScholarPubMed
Mason, SE, Noel-Storr, A, Ritchie, CW. The impact of general and regional anesthesia on the incidence of postoperative cognitive dysfunction and postoperative delirium: a systematic review with meta-analysis. J Alz Dis. 2010; 22(Suppl 3):6779.Google ScholarPubMed
Marcantonio, ER, Goldman, L, Orav, EJ, Cook, EF, Lee, TH. The association of intraoperative factors with the development of postoperative delirium. Am J Med. 1998; 105(5):380384.CrossRefGoogle ScholarPubMed
Parker, MJ, Handoll, HH, Griffiths, R. Anaesthesia for hip fracture surgery in adults. Cochrane Database Syst Rev. 2004(4):CD000521.Google ScholarPubMed
Radtke, FM, Franck, M, Lendner, J, et al. Monitoring depth of anaesthesia in a randomized trial decreases the rate of postoperative delirium but not postoperative cognitive dysfunction. Br J Anaesth. 2013; 110(Suppl 1):i98i105.CrossRefGoogle Scholar
Chan, MT, Cheng, BC, Lee, TM, Gin, T; Coda Trial Group. BIS-guided anesthesia decreases postoperative delirium and cognitive decline. J Neurosurg Anesthesiol. 2013; 25:3342.CrossRefGoogle ScholarPubMed
Whitlock, EL, Torres, BA, Lin, N, et al. Postoperative delirium in a substudy of cardiothoracic surgical patients in the BAG-RECALL clinical trial. Anesth Analg. 2014; 118:809817.CrossRefGoogle Scholar
Yocum, GT, Gaudet, JG, Teverbaugh, LA, et al. Neurocognitive performance in hypertensive patients after spine surgery. Anesthesiology. 2009; 110(2):254261.CrossRefGoogle ScholarPubMed
Patti, R, Saitta, M, Cusumano, G, Termine, G, Di Vita, G. Risk factors for postoperative delirium after colorectal surgery for carcinoma. Eur J Oncol Nurs. 2011; 15(5):519523.CrossRefGoogle ScholarPubMed
Williams-Russo, P, Sharrock, NE, Mattis, S, Szatrowski, TP, Charlson, ME. Cognitive effects after epidural vs general anesthesia in older adults. A randomized trial. JAMA. 1995; 274(1):4450.CrossRefGoogle ScholarPubMed
Moller, J, Cluitmans, P, Rasmussen, L, et al. Long-term postoperative cognitive dysfunction in the elderly: ISPOCD1 study. Lancet. 1998; 351:857861.CrossRefGoogle ScholarPubMed
Bijker, JB, van Klei, WA, Kappen, TH, et al. Incidence of intraoperative hypotension as a function of the chosen definition: literature definitions applied to a retrospective cohort using automated data collection. Anesthesiology. 2007; 107(2):213220.CrossRefGoogle ScholarPubMed
Joshi, B, Ono, M, Brown, C, et al. Predicting the limits of cerebral autoregulation during cardiopulmonary bypass. Anesth Analg. 2012; 114(3):503510.CrossRefGoogle ScholarPubMed
Wang, NY, Hirao, A, Sieber, F. Association between intraoperative blood pressure and postoperative delirium in elderly hip fracture patients. PLoS One. 2015; 10(4):e0123892.CrossRefGoogle ScholarPubMed
Gruber-Baldini, AL, Marcantonio, E, Orwig, D, et al. Delirium outcomes in a randomized trial of blood transfusion thresholds in hospitalized older adults with hip fracture. J Am Geriatr Soc. 2013; 61(8):12861295.CrossRefGoogle Scholar
Carson, JL, Terrin, ML, Noveck, H. Liberal or restrictive transfusion in high-risk patients after hip surgery. N Engl J Med. 2011; 365:24532462.CrossRefGoogle ScholarPubMed
Monk, TG, Price, CC. Postoperative cognitive disorders. Curr Opin Crit Care. 2011; 17(4):376381.CrossRefGoogle ScholarPubMed
Rasmussen, LS, Larsen, K, Houx, P, et al. The assessment of postoperative cognitive function. Acta Anaesthesiol Scand. 2001; 45(3):275289.CrossRefGoogle ScholarPubMed
Krenk, L, Rasmussen, LS. Postoperative delirium and postoperative cognitive dysfunction in the elderly: what are the differences? Minerva Anestesiol. 2011; 77(7):742749.Google ScholarPubMed
McDonagh, DL, Mathew, JP, White, WD, et al. Cognitive function after major noncardiac surgery, apolipoprotein E4 genotype, and biomarkers of brain injury. Anesthesiology. 2010; 112(4):852859.CrossRefGoogle ScholarPubMed
Newman, MF, Kirchner, JL, Phillips-Bute, B, et al. Longitudinal assessment of neurocognitive function after coronary-artery bypass surgery. NEJM. 2001; 344(6):395402.CrossRefGoogle ScholarPubMed
van Dijk, D, Spoor, M, Hijman, R, et al. Cognitive and cardiac outcomes 5 years after off-pump vs on-pump coronary artery bypass graft surgery. JAMA. 2007; 297(7):701708.CrossRefGoogle ScholarPubMed
Monk, TG, Weldon, BC, Garvan, CW, et al. Predictors of cognitive dysfunction after major noncardiac surgery. Anesthesiology. 2008; 108(1):1830.CrossRefGoogle ScholarPubMed
Ottens, TH, Dieleman, JM, Sauer, AM, et al. Effects of dexamethasone on cognitive decline after cardiac surgery: a randomized clinical trial. Anesthesiology. 2014; 121(3):492500.CrossRefGoogle ScholarPubMed
Silbert, B, Evered, L, Scott, DA, et al. Preexisting cognitive impairment is associated with postoperative cognitive dysfunction after hip joint replacement surgery. Anesthesiology. 2015; 122(6):12241234.CrossRefGoogle ScholarPubMed
Quinlan, N, Rudolph, JL. Postoperative delirium and functional decline after noncardiac surgery. J Am Geriatr Soc. 2011; 59(Suppl 2):S301S304.CrossRefGoogle ScholarPubMed
Abildstrom, H, Rasmussen, LS, Rentowl, P, et al. Cognitive dysfunction 1-2 years after non-cardiac surgery in the elderly. ISPOCD group. International Study of PostOperative Cognitive Dysfunction. Acta Anaesthesiol Scand. 2000; 44(10):12461251.CrossRefGoogle Scholar
Bruce, KM, Yelland, GW, Smith, JA, Robinson, SR. Recovery of cognitive function after coronary artery bypass graft operations. Ann Thorac Surg. 2013; 95(4):13061313.CrossRefGoogle ScholarPubMed
Cormack, F, Shipolini, A, Awad, WI, et al. A meta-analysis of cognitive outcome following coronary artery bypass graft surgery. Neurosci Biobehav Rev. 2012; 36(9):21182129.CrossRefGoogle ScholarPubMed
Selnes, OA, Gottesman, RF, Grega, MA, et al. Cognitive and neurologic outcomes after coronary-artery bypass surgery. N Engl J Med. 2012; 366(3):250257.CrossRefGoogle ScholarPubMed
Papaioannou, A, Fraidakis, O, Michaloudis, D, Balalis, C, Askitopoulou, H. The impact of the type of anaesthesia on cognitive status and delirium during the first postoperative days in elderly patients. Eur J Anesthesiol. 2005; 22(7):492499.CrossRefGoogle ScholarPubMed
Ballard, C, Jones, E, Gauge, N, et al. Optimised anaesthesia to reduce post operative cognitive decline (POCD) in older patients undergoing elective surgery, a randomised controlled trial. PLoS One. 2012; 7(6):e37410.CrossRefGoogle ScholarPubMed
Nadelson, MR, Sanders, RD, Avidan, MS. Perioperative cognitive trajectory in adults. Br J Anesth. 2014; 112(3):440451.CrossRefGoogle ScholarPubMed
Silbert, B, Evered, L, Scott, DA. Cognitive decline in the elderly: is anaesthesia implicated? Best Pract Res Clin Anaesthesiol. 2011; 25(3):379393.CrossRefGoogle ScholarPubMed
Evered, L, Scott, DA, Silbert, B, Maruff, P. Postoperative cognitive dysfunction is independent of type of surgery and anesthetic. Anesth Analg. 2011; 112(5):11791185.CrossRefGoogle ScholarPubMed
Hlatky, MA, Bacon, C, Boothroyd, D, et al. Cognitive function 5 years after randomization to coronary angioplasty or coronary artery bypass graft surgery. Circulation. 1997; 96(9 Suppl):II-11–14; discussion II-15.Google ScholarPubMed
Lal, BK, Younes, M, Cruz, G, et al. Cognitive changes after surgery vs stenting for carotid artery stenosis. J Vascul Surg. 2011; 54(3):691698.CrossRefGoogle ScholarPubMed
Selnes, OA, Grega, MA, Bailey, MM, et al. Neurocognitive outcomes 3 years after coronary artery bypass graft surgery: a controlled study. Ann Thorac Surg. 2007; 84(6):18851896.CrossRefGoogle ScholarPubMed
Selnes, OA, Grega, MA, Bailey, MM, et al. Cognition 6 years after surgical or medical therapy for coronary artery disease. Ann Neurol. 2008; 63(5):581590.CrossRefGoogle ScholarPubMed
Selnes, OA, Grega, MA, Bailey, MM, et al. Do management strategies for coronary artery disease influence 6-year cognitive outcomes? Ann Thor Surg. 2009; 88(2):445454.CrossRefGoogle ScholarPubMed
Shroyer, AL, Grover, FL, Hattler, B, et al. On-pump versus off-pump coronary-artery bypass surgery. N Engl J Med. 2009; 361(19):18271837.CrossRefGoogle ScholarPubMed
Silbert, BS, Evered, LA, Scott, DA. Incidence of postoperative cognitive dysfunction after general or spinal anaesthesia for extracorporeal shock wave lithotripsy. Br J Anaesth. 2014; 113:784791.CrossRefGoogle ScholarPubMed
Rasmussen, LS, Johnson, T, Kuipers, HM, et al. Does anaesthesia cause postoperative cognitive dysfunction? A randomised study of regional versus general anaesthesia in 438 elderly patients. Acta Anaesthesiol Scand. 2003; 47(3):260266.CrossRefGoogle ScholarPubMed
Farag, E, Chelune, GJ, Schubert, A, Mascha, EJ. Is depth of anesthesia, as assessed by the Bispectral Index, related to postoperative cognitive dysfunction and recovery? Anesth Analg. 2006; 103(3):633640.CrossRefGoogle ScholarPubMed
Avidan, MS, Searleman, AC, Storandt, M, et al. Long-term cognitive decline in older subjects was not attributable to noncardiac surgery or major illness. Anesthesiology. 2009; 111(5):964970.CrossRefGoogle ScholarPubMed
Neufeld, KJ, Leoutsakos, JM, Sieber, FE, et al. Outcomes of early delirium diagnosis after general anesthesia in the elderly. Anesth Analg. 2013; 117(2):471478.CrossRefGoogle ScholarPubMed
Abelha, FJ, Luis, C, Veiga, D, et al. Outcome and quality of life in patients with postoperative delirium during an ICU stay following major surgery. Crit Care. 2013; 17(5):R257.CrossRefGoogle ScholarPubMed
Pandharipande, PP, Girard, TD, Jackson, JC, et al. Long-term cognitive impairment after critical illness. N Engl J Med. 2013; 369(14):13061316.CrossRefGoogle ScholarPubMed
Steinmetz, J, Christensen, KB, Lund, T, et al. Long-term consequences of postoperative cognitive dysfunction. Anesthesiology. 2009; 110(3):548555.CrossRefGoogle ScholarPubMed
Steinmetz, J, Siersma, V, Kessing, LV, et al. Is postoperative cognitive dysfunction a risk factor for dementia? A cohort follow-up study. Br J Anaesth. 2013; 110(Suppl 1):i92i97.CrossRefGoogle ScholarPubMed
AGS/NIA Delirium Conference Writing Group, Planning Committee and Faculty. The American Geriatrics Society/National Institute on Aging Bedside-to-Bench Conference: research agenda on delirium in older adults. J Am Geriatr Soc. 2015; 63(5):843852.CrossRefGoogle Scholar
Anderson, DJ, Podgorny, K, Berrios-Torres, SI, et al. Strategies to prevent surgical site infections in acute care hospitals: 2014 update. Infect Control Hosp Epidemiol. 2014; 35(Suppl 2):S66S88.CrossRefGoogle ScholarPubMed

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