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6 - Mechanistic and Statistical Modelling of Bioprocesses

Published online by Cambridge University Press:  17 July 2020

Moritz Wolf ,
Jean-Marc Bielser  and
Massimo Morbidelli
Moritz Wolf
Affiliation:
Eidgenössische Technische Hochschule Zürich
Jean-Marc Bielser
Affiliation:
Merck Serono SA
Massimo Morbidelli
Affiliation:
Eidgenössische Technische Hochschule Zürich
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Summary

This chapter provides a general introduction for the application of mechanistic and statisticalmodels in bioreactor process development and optimisation. We first introduce the equations governing the behaviour of batch and continuous stirred tank reactors (CSTR) for a given chemical system. After presenting the criteria to generalise these concepts to biological systems and bioprocesses, we discuss the implementation of mechanistic models for the simulation and control of the bioreactor performance with particular emphasis on product quality attributes, such as N-linked glycosylation. In addition, we describe the implementation of statistical and hybrid models and their application in process development and reactor optimisation. Lastly, we compare the use of the various modelling techniques for process monitoring and control.

Keywords

Modelling Continuous stirred tank reactor Statistical models Hybrid models
Type
Chapter
Information
Perfusion Cell Culture Processes for Biopharmaceuticals
Process Development, Design, and Scale-up
 , pp. 138 - 173
Publisher: Cambridge University Press
Print publication year: 2020

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