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Chapter 26 - Non-Neoplastic Accumulation of Histiocytes

from Section VI - Histiocytic Disorders and Neoplasms

Published online by Cambridge University Press:  25 January 2024

By
Jennifer Picarsic
Edited by
Xiayuan Liang ,
Bradford Siegele  and
Jennifer Picarsic
Xiayuan Liang
Affiliation:
Children’s Hospital of Colorado
Bradford Siegele
Affiliation:
Children’s Hospital of Colorado
Jennifer Picarsic
Affiliation:
Cincinnati Childrens Hospital Medicine Center
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Summary

The ontogeny of native Langerhans cells (LCs) in the epidermis has been debated over the past decade, with most agreeing that such LCs are now best classified as specialized resident-tissue macrophages derived from the embryonic yolk sac that have a self-renewal capacity in the steady state, along with migratory dendritic cell (DC)–like properties (albeit with much slower migration as compared to conventional or classic DCs [cDCs]) (1). The diversity of the epidermal pool of resident and inflammatory macrophages and DCs may be greater than previously realized – with LCs, monocyte-derived LC-like cells, and inflammatory dendritic epidermal cells (IDECs) all acting as human antigen-presenting cells (1).

Type
Chapter
Information
Pediatric Pathology of Hematopoietic and Histiocytic Disorders , pp. 312 - 319
Publisher: Cambridge University Press
Print publication year: 2024

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